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Results for “Histocompatibility Testing”

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At least 19 recordsLinked to original sources
PubMed1975

[Evaluation of new histocompatibility tests for bone marrow transplantation].

Histocompatibility testing has been performed in the families of 20 patients with aplastic anemia or acute leukemia, in order to identify a compatible donor for marrow transplantation. In several cases, the interpretation of the tests has been difficult because of abnormalities in the immune reactivity of patients' lymphocytes. Humoral or cellular immunization against donor incompatible antigens seems to prevent a "take" of the graft or a subsequent hematological remission.

Acute Disease↗
PubMed1975

Histocompatibility testing in dogs. I. A semi-micro mixed lymphocyte culture (MLC) technique for histocompatibility matching in dogs.

A semi-micro method for the mixed lymphocyte culture (MLC) test in dogs is described. Optimization of various factors influencing the test were invistigated. Discrimination between allogeneic and isogeneic cell mixtures was possible after 90 h or culture but a culture period of 144 h was found to be optimal. The method measures MLC identity or non-identity and can be used as a tool for histocompatibility testing of lymphocyte defined (LD) Antigens.

Animals↗
PubMed1977

[Mixed lymphocyte culture (MLC) as a histocompatibility test for allogen grafts. Part II. technique, significance and applications (author's transl)].

This study introduces mixed lymphocyte culture (MLC) as a clinical method for prognostic assessment in allogen grafts. The principle and technical data are discussed. The technical variance and biological reproducibility of the MLC was tested by means of the recommendations of the Sixth International Histocompatibility Workshop 1975. The individual data show fluctuation, but the relative values and the order of rank are important. The order of rank is reproducible.

Analysis of Variance↗