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Results for “Histological grade”

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At least 19 recordsLinked to original sources

PubMed1979

Histological grading of transitional cell tumours of the bladder. Value of histological grading (WHO) in prognosis.

Mortality among 139 patients with transitional cell tumour of the bladder was studied. Tumours were reevaluated according to the grading system recommended by WHO. The absolute 5-year survival of histologically benign papilloma cases was 68%, of grade I carcinoma cases 64%, of grade II carcinoma cases 42% and of grade III carcinoma patients 34%. Clinical staging (UICC), however, would have been more effective than histological grading (WHO) for prognostic purposes. 3 of the 14 patients with histologically benign papilloma in this study developed grade I carcinoma during follow-up periods of between 4.5 and 24 years. Following radical treatment all recurrences were papillomas. The study suggests that histological grading should be used to complement clinical staging in prognosis and that with half-yearly check-ups and elimination of any tumours thus detected, patients with papilloma rarely develop carcinomas of higher grade than grade I.

Aged↗

PubMed1979

Histological grading and sequential morphological changes during the production of acute duodenal ulcers.

A method of grading histological changes in the duodenum and the sequential morphological appearances during the development of acute duodenal ulceration is described. After s.c. infusion of ulcerogenic doses of gastric secretagogues, rats were killed hourly and the duodenal lesions were graded from 1, which was the earliest change seen consisting of focal necrosis of the tips of villi to 6, which showed perforation of duodenal ulcer. For the first 4 h the duodenum was normal but after this there was progressive necrosis of the mucosa and submucosa, and inflammatory-cell infiltration. From 18 h rats were shown to have duodenal ulcers with or without perforation.

Acute Disease↗

PubMed2026

Intratumoral collagen correlates with histological grade and patient prognosis in breast cancer.

Histological grading, using the Nottingham Grading System (NGS), is a major prognostic indicator for breast cancer. NGS involves the scoring of cancer cell-related morphological features, yet it overlooks tumor microenvironment (TME) components such as collagen. Collagen proteins, integral to the extracellular matrix (ECM), influence tumor architecture and progression but their relationship with histological grade is not fully characterized. Here, we assessed intratumoral collagen deposition using Masson Trichrome staining of whole slides (n = 166), proteomic profiling (n = 2) and transcriptomic analyses of the METABRIC (n = 1827) and TCGA-BRCA (n = 753) cohorts. We showed that low-grade tumors display significantly higher intratumoral collagen deposition compared to high-grade tumors. Moreover, we demonstrated that collagen expression at the transcript and protein levels (Masson Trichrome) could discriminate Grade II carcinomas into distinct prognostic groups, in which patients with Grade II carcinomas with elevated levels of collagen expression were associated with lower pTNM stage and better survival outcomes. Our results support the inclusion of TME features, such as collagen deposition, to enhance prognostic accuracy in breast cancer.

Humans↗

PubMed1978

Transitional cell tumours of the urinary bladder. The histological grade (WHO) and the clinical stage (UICC).

Correlation of histological grade (WHO) with clinical stage (UICC) of transitional epithelial tumours of the bladder has been evaluated in 130 patients. A moderate statistically highly significant positive correlation was established (Pearson's r 0.37--0.75 and eta correlation ratio coefficient 0.49--0.81 in various subsets of the material). Transurethral biopsies gave on average 0.53 lower histological grade than open operative biopsies of the same tumours. The data show that the information contained in histological grade and clinical stage is parallel and support the idea that histological diagnosis of transitional cell carcinoma is possible also in the absence of histological evidence of invasion.

Aged↗

PubMed1992

A comparison of proliferating cell nuclear antigen (PCNA) immunostaining, nucleolar organizer region (AgNOR) staining, and histological grading in gastrointestinal stromal tumours.

Gastrointestinal stromal tumours are lesions in which it is difficult to predict clinical outcome from the histological appearances. Sixty cases were studied using three different methods of assessing aspects of cellular proliferation; these were (i) immunostaining for proliferating cell nuclear antigen (PCNA), (ii) interphase nucleolar organizer region staining (AgNORs), and (iii) a histological grading system based on mitotic counts. Both PCNA immunostaining and AgNOR counts were found to correlate well with histological grading and all three methods independently showed good correlations with survival. This suggests that these proliferation-associated markers may be used as additional features to support histological grading in this relatively uncommon group of tumours.

Antigens, Neoplasm↗

PubMedDate not supplied

Low, intermediate and high grade breast carcinomas as determined by histotyping, immunohistochemical prognosticators and histological grading.

Low grade breast cancers i.e. mucinous (17 cases--3.2%), tubular (7 cases--1.3%) and invasive cribriform carcinomas (3 cases--0.5%) have been identified within a series of 524 breast cancers only by histotyping in hematoxylin-eosin stained sections: the reactivities of immunohistochemical prognosticators as estrogen/progesterone receptors (ER, PgR), growth fraction (GF: Ki67), p53 and c-erbB-2 oncoproteins are in agreement with clinical behaviours. Invasive papillary carcinomas (9 cases--1.6%) are not to be considered low grade carcinomas. Intermediate grade cancers are also determined by histotyping. Medullary carcinoma (13 cases--3.4%) has a paradoxical behaviour displaying a favourable clinical prognosis together with high grading and GF, absence of ER, PgR, high p53 and c-erbB-2 values, as compared with invasive ductal carcinomas: an extensive tissue immune response as suggested by a heavy lymphocyte infiltration may explain this behaviour. Invasive lobular carcinoma (62--11.6%) shows an intermediate immunohistochemical pattern, paralleling an intermediate prognosis, when compared with low and high grade carcinomas: ER, PgR and GF positivities are nearly the same as in ductal carcinomas whereas grading, p53 and c-erbB-2 are less expressed. These data are confirmed both for lobular carcinomas as a whole and for all variants of this kind of tumors. Invasive ductal carcinomas (413 cases--79%) may be stratified on three prognostic classes corresponding to histological grading (G1, G2, G3). Significant relationships of grading with all the immunohistochemical prognosticators studied has been observed. It may be concluded that grading is a parameter of paramount importance in this group of tumors.

Antigens, Neoplasm↗

PubMed1979

Histologic grade in advanced ovarian cancer.

The histologic grade of epithelial ovarian tumors was found to be a major prognostic factor for survival in patients with advanced (stage III-IV) disease. In addition, a grading system based on cytologic detail (modified Broders' grades I-IV) identified groups with a differential response to chemotherapy. The overall improvement in survival observed with combination chemotherapy was related primarily to an increased survival of patients with grade II and III lesions. Although the survival of patients with grade I lesions was markedly better than for patients with grade IV lesions, in neither case was it influenced by the choice of single-agent or combination chemotherapy. In prospective clinical trials in advanced disease, modified Broders' grades should be included as a separate stratification factor.

Altretamine↗

PubMed1992

Prognostic factors for recurrent breast cancer: univariate and multivariate analyses including histologic grade and amplification of the c-erbB-2 proto-oncogene.

Post-recurrence survival was examined in 62 breast cancer patients who had undergone curative radical mastectomies between 1974 and 1976 and suffered recurrences within 127 months of surgery. The prognostic value of 11 clinical, histological and genetic factors, including histologic grade of malignancy and amplification of oncogenes was analyzed using univariate and multivariate analyses. Not only the site of first recurrence, clinical stage and size of primary tumor at initial surgery, and disease-free period, but also histologic grade and amplification of the c-erbB-2 proto-oncogene were significant prognostic indicators of recurrent breast cancer. Multivariate analysis using Cox's regression model, histologic grade and amplification of c-erbB-2 in the primary tumor, as well as clinical stage at surgery and site of first recurrence, were shown to be major independent prognostic factors of recurrent breast cancer. Because post-recurrence prognosis was strongly influenced by the clinical, histological and genetic status of the primary breast cancer, appropriate evaluation of the primary tumor for the grade of aggressiveness of the cancer cells, as well as the extent of cancer spread, seem to be important.

Biomarkers, Tumor↗

PubMed1978

Histologic grading of Wilms' tumor as potential prognostic factor: results of a retrospective study of 26 patients.

A histologic grading system based on tumor differentiation was applied in a retrospective study of 26 patients with Wilms' tumor to determine if it might provide an index to prognosis. The results were compared to those obtained by applying a histologic classification based on the presence or absence of individual histologic structures to the same tumors. Low grade tumors with predominance of differentiated structures--glomeruli and tubules--were associated with a better cure rate than high grade tumors composed mainly of undifferentiated spindle elements. The presence of undifferentiated large cells correlated with poor cure rate. The findings suggest that histologic grading may be valid as a prognostic factor in Wilms' tumor.

Adolescent↗

PubMed1977

The prognosis in carcinoma of the prostate, judged on the basis of clinical classification into stages and histological grading.

On the basis of a retrospective study of 61 cases of carcinoma of the prostate, it is attempted to evaluate the prognosis, either by way of a clinical classification into stages or by histological grading. Both types showed a clear-cut correlation with the prognosis. Collation of the clinical classification into stages and the histological grading of the lesions in 33 patients showed that the two methods represented two unrelated types of classification.

Aged↗

PubMed1979

Histological grade and other prognostic factors in relation to survival of patients with breast cancer.

Records of 3085 patients registered with breast cancer at the Mersey Regional Cancer Registry have been analysed to evaluate the relative importance of possible prognostic factors. In a subgroup of 1759 patients, clinical stage and histological grade are shown to be strongly related to survival after treatment. In addition histological grade is related to the distribution of times to death after treatment. The results of this and 3 other studies have implications for the design and analysis of clinical trials in the primary treatment of breast cancer.

Age Factors↗

PubMed1976

Histological grading of renal cell carcinoma.

The Erlangen system of histologic grading of the malignancy of renal cell cancers is described in detail. It takes into consideration the type of cell and pattern of the tumor and differentiates between grades 1, 2, and 3. Grade 1 was observed in 10%, grade 2 in 51%, and grade 3 in 39% of the cases. The difference in the 5-year survival rates between tumors of grade 3 and those of tumors of grades 1 and 2 is statistically significant.

Adenocarcinoma↗

PubMed1975

Histologic grading of malignancy and prognosis in glottic carcinoma of the larynx.

Two hundred and thirty patients with glottic carcinomas of the larynx treated at the Radiumhemmet from 1956 to 1966 by radiotherapy and followed for at least five years were investigated. Histologic grading of malignancy was made in each case by the registration of eight morphologic criteria, four representing the tumor cell population itself (structure, differentiation, nuclear polymorphism, and mitoses) and four representing the tumor host relationship (mode of invasion, stage of invasion, vascular invasion, and cellular response). There parameters were graded on the bases of a one to four point system according to arbitrary units. Multivariate analysis of the material revealed that the most important factors in the prediction of the five year result were found to be the nuclear polymorphism, mode of invasion, and total malignancy point value. The histologic grading of malignancy in this series was found to be better in the prediction of the five year result, recurrence or not, than the TNM classification.

Adult↗

PubMed1992

Immunohistochemical studies on oncogene products (EGF-R, c-erbB-2) and growth factors (EGF, TGF-alpha) in human breast cancer: their relationship to oestrogen receptor status, histological grade, mitotic index and nodal status.

In this investigation, 83 human mammary carcinomas were examined for the expression of oestrogen receptor (ER), epidermal growth factor receptor (EGF-R), epidermal growth factor (EGF), transforming growth factor alpha (TGF-alpha), c-erbB-2, histological grade, mitotic index and nodal status, all of which are reportedly prognostically significant factors (Bloom and Richardson 1957; Baak et al. 1985; Wright et al. 1989). ER expression was biochemically recognized in 43.4% of mammary carcinomas, and EGF-R, EGF, TGF-alpha and c-erbB-2 were histochemically recognized in 25.3, 14.5, 27.7 and 18.0% of mammary carcinomas examined respectively, using conventional sections of buffered formalin-fixed, paraffin-embedded tissue and monoclonal or polyclonal antibodies. There were significant relationships between negative ER and positive EGF-R or TGF-alpha; positive EGF-R and TGF-alpha; positive EGF-R and c-erbB-2; and positive c-erbB-2 and TGF-alpha. The single changes which were the negative ER and the positive c-erbB-2 correlated with histological grade and mitotic index. Co-expression of EGF-R and TGF-alpha correlated with positive nodal status. Therefore, the present investigation indicates that the negative ER, single expression of c-erbB-2 and co-expression of EGF-R and TGF-alpha are important markers which contribute indirectly to prognosis, which reconfirms previous findings on the former two while adding the new finding that immunohistochemical demonstration of expression of EGF-R and TGF-alpha may provide useful information for selecting the appropriate treatment.

Biomarkers, Tumor↗

PubMed1976

Prostatic carcinoma. relationship between primary tumor, histologic grade, and response to chemotherapy.

This National Cooperative Study has randomly compared the usefulness of 5-fluorouracil (5-FU), cyclophosphamide (Cytoxan) and standard therapy in patients with advanced carcinoma of the prostate (Stage D). All patients studied were endocrine failures and were in progression. Favorable responses were seen with all three treatments regardless of histologic grade. Actual tumor regression occurred only in patients who received either 5-FU or cyclophosphamide. In patients with poorly differentiated or anaplastic tumors treated with cyclophosphamide, progression of disease was significantly less rapid than in patients treated with 5-FU or standard therapy. However, favorable responders could not always be identified in advance on the basis of histologic grade alone.

Carcinoma↗

PubMed1977

[Results of radiation therapy in Brill-Symmers' disease with special consideration to histological grading (author's transl)].

Histological preparations from 22 irradiated patients with gigantofollicular lymphoblastoma Brill-Symmers have been reviewed and graded in accordance with the Kiel classification 1974. Corresponding to this, 19 patients had centroblastic-centrocytic lymphoma and three a centroblastic sarcoma. In the three sub-groups of centroblastic-centrocylic lymphomas, no essential differences were found in stages I-III with respect to anamnesis or clinical findings before the onset of treatment, or to the previous course of the disease. Centroblastic sarcoma, ranging among the lymphomas with a high degree of malignancy, has manifested unfavorable progressive courses in all patients.

Adolescent↗

PubMed1978

[Oligodendroglioma. Clinical course in relation to histological grading].

The history of 99 patients, operated on for oligodendroglioma, has been related to the microscopic picture of the tumours which were graded in three stages of malignancy. Clinical course and histological grading fit together well. Certain signs and symptoms correlate with the kind of tumour. The prognosis in oligodendroglioma is as bad as in astrocytoma. The danger of recurrence is high, even after radical operation. Radiation therapy is useless.

Adolescent↗

PubMed1977

Juxtacortical (parosteal) osteogenic sarcoma: histological grading and prognosis.

In twenty-four cases of juxtacortical osteogenic sarcoma, three histological grades of malignancy were identified and correlated with the prognosis. The eighteen patients with Grade-I or II tumors had a significantly better prognosis than the six with Grade-III lesions. The three grades could not be distinguished roentgenographically. Grade I and II tumors, which showed a high cure rate after amputation, may be amenable to en block resection, provided the entire tumor can be removed with a good margin of uninvolved soft tissue and underlying bone. Grade-III tumors, on the other hand, had a poor prognosis despite early radical surgery.

Adolescent↗