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Experience and early results following heart transplantation at the Humana Heart Institute.

Five elective and one emergency orthotopic heart transplantation were performed in six patients, 32 to 54 years of age. Postoperative complications included transient renal failure in four patients with need for dialysis in one, seizure in one, and herpes infections in four. Immunosuppression of the first three patients consisted of cyclosporine and prednisone. The last three received cyclosporine and azathioprine, with prednisone added later for control of rejection. All six patients are home and well.

Adolescent↗
PubMed1987

Malignant clinical behavior of cardiac myxomas and "myxoid imitators".

The clinical experience with cardiac myxomas and "myxoid imitators" at the Humana Heart Institute International is reviewed and contrasted with a comprehensive review of the world literature. Twenty-two patients with primary cardiac tumors have been treated at our institution. Three (13.6%) of them had myxoid imitators, and 19 had classic myxomas. One of the 19 patients with a classic myxoma had recurrence on two occasions (recurrence rate, 5.3%). The cases of 57 patients from the world literature are reviewed. Recurrence and/or metastases (including formation of mycotic aneurysm) occurred in approximately 50% of these patients. The overall mortality in these patients was 47%. This review provides documentation of the malignant clinical behavior of cardiac myxomas and myxoid imitators. Neither local recurrence nor regrowth of the tumor in a new location, whether intracardiac or extracardiac, can be predicted from the microscopic appearance of the primary tumor. Resection of the myxoma with a wide margin is the recommended surgical procedure but does not ensure a cure. Therefore, long-term follow-up is mandatory.

Fibroma↗
PubMed1986

Ethical issues related to the artificial heart.

This paper is a general survey of ethical issues related to the artificial heart. It begins by looking at the history of funding of the artificial heart program through the National Institute of Health in 1965. Attention is paid to the problem of the lack of planning related to social, ethical, economic, and legal implications. The paper then deals with three areas of ethical concerns. They are those issues relating to the experimental versus therapeutic benefits, the cost, and public involvement with a private interest.

Ethics Committees, Research↗
PubMed1985

Doctor knows best.

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Artificial Organs↗