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At least 19 recordsLinked to original sources
PubMed1979

Incidence of non-cholera vibrios in Hungary.

In the period 1971 to 1976, 200 non-cholera vibrio (NCV) strains were isolated in Hungary; 18 of the cultures were derived from 34 729 faecal and 182 from 237 surface water samples. Ninety-two strains belonged to the Heiberg-Smith group I and 108 to group II. Two strains failed to give the string test and 3 were pteridine resistant. The strains were classified into 48 serotypes according to Smith's system. Faecal NCV strains belonged to serotypes 46 and 328; these serotypes did not occur in water. Of the 18 faecal strains 13 were isolated from 18 048 persons who had travelled in cholera-infected areas, and 5 strains from persons who had never left Hungary (2 from 4559 patients with diarrhoea and 3 from 6061 healthy individuals). These data indicate that although NCV are present in the environment, they play an insignificant role in enteric infections in Hungary.

Bacterial Toxins↗
PubMed1976

Precipitating antibodies to Crimean haemorrhagic fever virus in human sera collected in Hungary.

Agar-gel diffusion precipitation test was carried out with Crimean Haemorrhagic Fever (CHF) virus as antigen in serum samples collected in four areas of Hungary from 587 persons working in contact with animals, and in 169 animal sera collected in Hajdu-Bihar county, Hungary. Antibody was found in 17 human sera. All these but one, originating from a slaughterhouse worker in Budapest, had been collected from Hajdú-Bihar county. The highest titre was 1:16. All the animal sera proved to be negative. It is suggested that the CHF virus or a closely related virus is present, and may cause human infections in Hungary.

Abattoirs↗
PubMed1977

Down's syndrome: chromosome analysis of 362 cases in Hungary.

A survey is given of the karyotypes observed in 362 children clinically diagnosed as cases of Down's syndrome from whom material was sent to 8 collaborating cytogenic laboratories in Hungary during the period 1965-1974. The sample studied cytogenetically constitutes about 20% of all children born in Hungary in this decade with Down's syndrome. The ways in which patients were selected for cytogenetic examinations could not be specified. In the sample, standard trisomy 21 was found in 91.7%, translocations in 3.9% and mosaicism in 4.4%. The mean age of the mothers of the children investigated was 29.05 years, a relatively low figure which may be explained by the decrease of the mean maternal age over the last decades.

Adult↗
PubMed1979

Position of bioengineering education in Hungary.

Medical electronic equipment has been produced in Hungary since the early forties. Industrial production of bioengineering started only in 1957. At the same time the bioengineering section of the Scientific Society of Measurement and Automation was founded. This Section was instrumental in recognizing the necessity for and establishing a structured education programme in bioengineering which started in the Postgraduate Institute for Engineers within Budapest Technical University. Later this was incorporated in the programme of the Technical University as an optional subject. Today there is also a specialised engineering course at the Technical University. There are significant developments in the bioengineering education of physicians and medical students. This paper deals with the possibility of classification bioengineering devices which has proved useful in education in Hungary.

Biomedical Engineering↗
PubMed1979

Haemagglutination-inhibiting antibodies to B.K. virus in Hungary.

Antibody inhibiting the haemagglutination by B.K. virus was found in 64% of the serum samples collected from 949 subjects in Hungary. The frequency of seropositivity was the lowest (17%) among infants 1 and 2 years of age and the highest (93%) in the age group 16 to 20 years. The subsequent age groups showed a slow continuous decline. The age-distribution curve drawn on the basis of the geometric means of titres has two peaks, one between 3 and 5 years of age and another between 21 and 30 years of age, reaching 6.74 and 7.05, respectively, as expressed in terms of log2 units. The prevalence of haemagglutination-inhibiting antibody to B.K. virus in Hungary and its distribution by age are similar to those reported from other European countries.

Adolescent↗
PubMed1978

[Comparative investigations on polymorphism of the red cell enzymes in Franconia and West Hungary (author's transl)].

The distribution of the phenotypes of the red cell enzymes adenosine deaminase, adenylate kinase, glutamate pyruvate dehydrogenase, 6-phosphogluconate dehydrogenase and phosphoglucomutase was studied in blood samples of 794 West Hungarian subjects and 955 subjects from Franconia in Bavaria. All enzymes were separated on cellulose acetate foil, SEP in starch gel. The method of separation has been described elsewhere. The phenotypes of all enzymes were found to be distributed according to the Hardy-Weinberg law. The calculated gene frequencies were in good agreement with data from the literature, according to the results of other investigations carried out in Germany and the central European region. No significant difference was found between the gene frequencies of these enzyme phenotypes in West Hungary and Franconia, although the PGM2 frequency level was higher in West Hungary than in Franconia.

Acid Phosphatase↗
PubMed2026

Coexistence of carbapenemase and hypervirulence-associated genes among Klebsiella pneumoniae high-risk clones in Hungary.

INTRODUCTION: Strains of Klebsiella pneumoniae carrying hypervirulence and carbapenemase genes represent a rapidly emerging global public health threat. Our study aimed to comprehensively characterise the genomics of hypervirulence-associated and carbapenemase genes carrying K. pneumoniae (hv(a)CpKp) isolates in Hungary. MATERIALS AND METHODS: Between January 2022 and April 2024, 89 aerobactin (iucA-D/iutA)-positive non-duplicate carbapenemase-producing K. pneumoniae isolates from 15 Hungarian healthcare institutes underwent short-read (Illumina, MiSeq, NextSeq) whole-genome sequencing, followed by detailed plasmid analysis using long-read sequencing (Nanopore, MinION) in a representative subset of 32 strains. RESULTS: Most isolates (79/89) belonged to the high-risk clone ST147. Hypervirulence-associated (hva) genes-including rmpA/rmpA2, peg344, shiF, iucA-D, and iutA-were universally present, and 59 isolates possessed chromosomally integrated yersiniabactin loci. Most isolates (87/89) carried the bla NDM-1 carbapenemase gene. Hypervirulence-associated genes were most frequently (29/32) associated with IncHI1B/IncFIB(Mar) plasmids. Notably, we identified plasmids carrying both hva and carbapenemase genes-designated as hybrid plasmids-in 13 of 32 strains. The bla NDM-1 was linked to the IS26 transposase and was present in conserved, identical cassettes on all bla NDM-1-carrying plasmids. DISCUSSION/CONCLUSION: Our study identified hv(a)CpKp strains, particularly the ST147 clone, circulating in Hungary. Our findings highlight the need for routine virulence gene monitoring and continuous genomic and plasmid-based surveillance to mitigate the clinical and epidemiological impact of emerging hv(a)CpKp lineages.

Klebsiella pneumoniae↗
PubMed2026

Novel avian calicivirus genome with type IV internal ribosomal entry site (IRES) in black-headed gull (Chroicocephalus ridibundus) in Hungary.

In this study, a taxonomically novel avian calicivirus detected and characterized by next generation sequencing, RT-PCR and Sanger sequencing methods in faecal specimen collected from black-headed gull (Chroicocephalus ridibundus) in Hungary. The complete genome length of the calicivirus strain gull/HA15097/HUN/2018 (PZ810127) is remarkably long, 8,845 nucleotides, which had type IV internal ribosomal entry site (IRES) at the 5', and a stem-loop-II-like (s2m) sequence motif at the 3' untranslated regions. The VP1 capsid protein had less than 26% aa identity to the members of the known calicivirus genera. Caliciviruses appear to be widespread not only in mammals including humans but also in various bird species.

Animals↗
PubMed1979

A comparative study of involutional depressive patients in French Canada and in Hungary.

The data dealing with 200 involutional depressive patients who were treated in Quebec City and in Budapest are presented. A questionnaire prepared for this purpose is produced and evaluated. Half of the Canadian and 80% of the Hungarian patients were personally interviewed by the author. Those patients with organic brain syndromes were not included in the population studied. Besides many similarities between the two groups, there were also symptomatological differences observed, e.g. the agitated type of involutional melancholy occurred twice as often in Canada as in Hungary, the apathetic cases were rarer in Canada, and the illness began earlier among Canadian women. Self-blame in Canada was often linked to religious observation. Two typical syndromes in male and female patients are detailed as special disease patterns. The symptomatology of this disorder has become identical in the last few years in both countries, therefore it is improbable that a similar study in the future could point out the differences described here.

Aged↗
PubMed1979

A comparative study of involutional depressive patients in French Canada and in Hungary.

The data dealing with 200 involutional depressive patients who were treated in Quebec City and in Budapest are presented. A questionnnaire prepared for this purpose is produced and evaluated. Half of the Canadian and 80% of the Hungarian patients were personally interviewed by the author. Those patients with organic brain syndromes were not included in the population studied. Besides many similarities between the two groups, there were also symptomatological differences observed, e.g. the agitated type of involutional melancholy occurred twice as often in Canada as in Hungary, the apathetic cases were rarer in Canada, and the illness began earlier among Canadian women. Self-blame in Canada was often linked to religious observation. Two typical syndromes in male and female patients are detailed as special disease patterns. The symptomatology of this disorder has become identical in the last few years in both countries, therefore it is improbable that a similar study in the future could point out the differences described here.

Age Factors↗
PubMed1979

Rickettsiae of the spotted fever group in Hungary.

Rickettsiae were detected by haemocyte test in 7.2% of Dermacentor marginatus and 4.7% of D. reticulatus ticks collected in Hungary. Six strains of rickettsiae were isolated from positive specimens. These rickettsiae according to CFR are closely related, probably identical with R. slovaca and they represent the first rickettsiae of the Spotted Fever group found in that country.

Dermacentor↗
PubMed1979

The control of immunobiological preparations in Hungary and its importance for national vaccination programmes.

In Hungary the control of immunobiological preparations has been regulated by legal orders since 1938. In the meantime the pertinent rules have been modifed several times, to keep them abreast with current development. The authority of state control has been vested into the Vaccine Control Department of the National Institute of Public Health (OKI), which in this capacity has maintained an intensive collaboration with the producer of immunobiological preparations, the HUMAN Institute of Serobacteriological Production and Research (HUMAN). As a result, several important vaccine preparations (pox, DPT, DT, tetanus, typhoid and BCG vaccines) employed in compulsory immunization programmes have been improved considerably in respect of safety and efficiency, on the basis of laboratory tests, controlled field trials and epidemiological observations, described in detail in this review.

BCG Vaccine↗
PubMed1978

Point prevalence at birth of ventricular septal defect in Hungary.

An attempt was made to estimate the occurrence of ventricular septal defect in Hungary. The study was based on data derived from three surveys. Point prevalence at birth of isolated ventricular septal defects amounted to 1.33 +/- 0.34%, 1.39 +/- 0.31% and 1.77 +/- 1.12%, respectively. Considering the diagnostic difficulties and other distorting factors, the figure of 1.5% is assumed to represent the actual point prevalence rate. Ventricular septal defect cases constituting part of the complex congenital cardiovascular malformations and of multiple malformations may increase the above 1.5% estimate by another 1%.

Heart Septal Defects, Ventricular↗