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At least 19 recordsLinked to original sources
PubMed1961

The effect of morphine on the adrenergic nerves of the isolated guinea-pig jejunum.

Nerves accompanying the mesenteric blood-vessels of the isolated guinea-pig jejunum were stimulated and changes in the longitudinal muscle coat were recorded. Stimulation of the nerves led to a rapid relaxation if the intestine was contracted by a previous administration of histamine. The relaxation was inhibited by morphine and partially restored by nalorphine. Bretylium and atropine also inhibited the relaxation and cocaine increased it somewhat. Morphine, atropine, and bretylium had no significant effect on the depressant action of noradrenaline on histamine contractions, whereas cocaine slightly enhanced the action of noradrenaline. Morphine, but not the other drugs, prevented the inhibitory action of dopamine.

Adrenergic Agents↗
PubMed1961

Assay of substance P on goldfish intestine in a microbath.

A technique is described for testing the effects of drugs on the intestine of goldfish in a microbath (0.05 ml.). This preparation may be used for the assay of substance P, which causes contractions of the muscle in doses as small as 1 m-u. Other substances in tissue extracts also act on this muscle, but the effects of most of these can be abolished by antagonists. Some tissues, however, contain an unknown substance which causes powerful contractions of the muscle and interferes with the assay of substance P. An attempt to demonstrate the release of substance P in the central nervous system was unsuccessful.

Animals↗
PubMed1962

Stimulation of intestinal nervous elements by angiotensin.

The stimulation of nervous elements in the intestine by the polypeptide angiotensin has been examined. Comparisons between nicotine, a neurotropic agent, acetylcholine which exerts principally a musculotropic action and angiotensin have been made by examining their interactions with hexamethonium and the anticholinesterase 1,5-di-(p-N-allyl-N-methylaminophenyl)pentan-3-one dibromide in both the rabbit and guinea-pig ileum. The effect of atropine on the responses of the guinea-pig ileum and botulinum toxin on the responses of the rabbit ileum to angiotensin was also tested. The results show that angiotensin causes most of its contractile response in both the guinea-pig and rabbit ileum by an indirect action, through the stimulation of nervous tissue.

Acetylcholine↗
PubMed1960

Serotonin, bananas, and diarrhoea.

From previous studies on serotonin it seemed possible that it might play a major rôle in determining the rhythm of the bowel in man. This hypothesis was tested, with negative results, by observing the effect of giving bananas, a rich natural source of serotonin, to normal subjects and by measuring the excretion of 5-hydroxyindolacetic acid in patients with diarrhoea.

Diarrhea↗