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A modified approach to the ilium to obtain graft material.

The ilium is a commonly utilized site for obtaining graft material for maxillofacial reconstruction. Pain, decreased mobility, and equivocal esthetics are complications sometimes encountered postoperatively with most current ilium harvesting techniques. A new approach to the ilium for obtaining marrow and cancellous bone was used in 26 cases during a one-year period. No complications encountered in the donor site. The technique is simple, allows simultaneous procedures, and is esthetically acceptable.

Curettage

Use of a craniotome for obtaining cancellous bone and marrow from the ilium.

The ilium is a rich source of cancellous bone and marrow for grafting. Grafts can be harvested very rapidly with a standard craniotome. The clutch mechanism prevents inadvertent soft tissue injury if both cortical plates are perforated. The surgical approach is similar to that used in other techniques. No complications have been encountered.

Bone Marrow Transplantation

[Evaluation of the myeloculture by puncture of the ilium crest for isolation of Brucella from patients with brucellosis].

Hemocultures and myelocultures of samples obtained from the ilium crest were made simultaneously of 61 patients with serologic diagnosis of brucellosis. Five strains were isolated by both methods and 18, by myeloculture only. All samples from which Brucella were isolated by hemoculture were also positive by myeloculture. The advantages of making myelocultures of patients previously treated with antibiotics are emphasized.

Adult

Quantitative microscopic studies of the distribution and retention of 239Pu in the ilium of the female CBA mouse.

Three month old female CBA mice were injected with 50 nCi kg-1 body mass of minimally polymeric 239Pu-citrate and killed at 24 hours, 10 days, 1 month and 3 months after injection. The distribution of 239Pu in the ilia of these mice was analysed using neutron-induced autoradiography of bone sections together with computer-based methods of data reduction. Results of these investigations demonstrate that while 239Pu is initially localized on bone surfaces, by 3 months after injection it is fairly uniformly distributed throughout mineral bone and its included marrow.

Animals

Comparison of ilium to rib for bone grafting in defects of canine mandibular alveolar fidge.

The behavior of iliac and rib grafts in surgically created defects in canine alveolar ridges was investigated. Despite the greater amount of potentially osteogenic tissue in the iliac graft, no significant qualitative differences were noted in the bony remodeling for a year. However, the rib grafts did form a mature superior cortical border significantly more rapidly, leading to speculation on the advantages of rib over iliac graft in alveolar ridge grafting.

Alveoloplasty

The long-term effects of spinal fusion on the sacroiliac joints and ilium.

Ninety-six patients who had lumbar disk excision and primary posterior fusion were studied 10 or more years after their operations. Thirty-seven per cent complained of persistent graft donor site pain. A comparison of fused patients with and without donor site pain and 36 patients who underwent simple disk excision, revealed no differences in the flexion-extension mobility of the sacroiliac joints, or degenerative changes in the sacroiliac joints. Ectopic bone formation at graft donor sites, and cluneal nerve neuromata did not influence the result. Patients with graft donor site pain had significantly greater complaints of persistent low back pain, postoperative leg pain, and lost more time from work. If the graft was taken from the same side as that of preoperative leg pain, persistent complaints were more common. It is concluded that the sacroiliac joints are not adversely affected by lumbar spine fusion, and that persistent donor site pain is more likely part of a total pain complex referred from the lumbar spine. The sacroiliac joints appear to be relatively noncontributory to problems following lumbar disk surgery.

Bone Transplantation

The evolution of hominin bipedalism in two steps.

Bipedalism is a human-defining trait1-3. It is made possible by the familiar, bowl-shaped pelvis, whose short, wide iliac blades curve along the sides of the body to stabilize walking and support internal organs and a large-brained, broad-shouldered baby4-6. The ilium changes compared with living primates are an evolutionary novelty7. However, how this evolution came about remains unknown. Here, using a multifaceted histological, comparative genomic and functional genomic approach, we identified the developmental bases of the morphogenetic shifts in the human pelvis that made bipedalism possible. First, we observe that the human ilium cartilage growth plate underwent a heterotopic shift, residing perpendicular to the orientation present in other primate (and mouse) ilia. Second, we observe heterochronic and heterotopic shifts in ossification that are unlike those in non-human primate ilia or human long bones. Ossification initiates posteriorly, resides externally with fibroblast (and perichondral) cells contributing to osteoblasts, and is delayed compared with other bones in humans and with primate ilia. Underlying these two shifts are regulatory changes in an integrated chondrocyte-perichondral-osteoblast pathway, involving complex hierarchical interactions between SOX9-ZNF521-PTH1R and RUNX2-FOXP1/2. These innovations facilitated further growth of the human pelvis and the unique formation of the ilium among primates.

Animals

Review of bone grafting for reconstruction of discontinuity defects of the mandible.

Thirty-eight patients with discontinuity defects of the mandible were hospitalized at Iwate Medical University School of Dentistry during the 12-year period from 1965 to 1976. Treatment consisted of grafting autogenous ilium and rib in 35 patients and isologous ilium and Kiel bone in three patients. No bony union was noted in four of 28 cases involving benign tumors, three of eight cases involving malignant tumors, and one of two cases involving old fractures. Postoperative infection was the main cause for lack of union.

Bone Transplantation

Growth and development of the acetabulum in the normal child. Anatomical, histological, and roentgenographic studies.

Postmortem studies of ten normal full-term infants and of three children, seven, nine, and fourteen years old, showed that the acetabular cartilage complex is a unit that is triradiate medially and cup-shaped laterally and is interposed between the ilium, ischium, and pubis. This complex is composed of epiphyseal growth-plate cartilage adjacent to these bones, of articular cartilage adjacent to these bones, of articular cartilage around the acetabular cavity, and, for the most part, of hyaline carilage. Interstitial growth within the triradiate part of the cartilage complex causes the hip socket to expand during growth. The concavity of the acetabulum develops in response to the presence of the spherical femoral head. The depth of the acetabulum increased during development as the result of interstitial growth in the acetabular cartilage, of appositional growth at the periphery of this cartilage, and of periosteal new-bone formation at the acetabular margin. At puberty, three secondary centers of ossification appear in the hyaline cartilage surrounding the acetabular cavity. These centers are homologous with other epiphyses in the skeleton. The os acetabuli, which is the epiphysis of the os pubis, forms the anterior wall of the acetabulum. The epiphysis of the ilium, which has been called the acetabular epiphysis, forms a good part of the superior wall of the acetabulum. A small epiphysis of the ischium was seen in the oldest patient, who was fourteen years old. The bone in these epiphyses expands toward the periphery of the acetabulum and thus contributes to its increase in depth.

Acetabulum

The conservative hemipelvectomy.

Conservative hemipelvectomy is the resection of the ischium, ilium and subjacent extremity. It differs from the orthodox hemipelvectomy method by retaining the ilium, which permits the patient to have normal balance, Sarcomas of the soft tissue extend toward the attachment of the pelvis. The operation has been performed upon ten patients, and the entire operative procedure can be done using the anterior approach, thus minimizing the need to turn the patient. This technique is less traumatic than either disarticulation of the hip joint or hemipelvectomy and can be performed in approximately one and one-half hours, blood loss being limited to an amount varying from 500 milliliters to 1 liter. No postoperative deaths have been recorded. Of the ten patients operated upon, none have had a local recurrence. One obese elderly woman with a liposarcoma died two years after operation from diffuse metastases. The other nine patients are alive and well from two to six years after amputation. The balance of these patients is manifested by the fact that two of them are excellent amputee-skiers.

Amputation, Surgical