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At least 19 recordsLinked to original sources
PubMed1993

The legal threat to medicine reconsidered.

The paper is concerned, in the main, with selective non-treatment of those incapable of making treatment decisions of their own. It draws attention to the conflict between the law and the medical profession in this field which was predicted some ten years ago and traces the British case law from then until the present day. It concludes that there is no such legal threat to medical practice in Great Britain and that any doubtful practices are currently controlled through the concept of the health care team.

Euthanasia↗
PubMed1994

Selective treatment decisions and the legal rights of very young infants.

Selective treatment of neonatal infants who are terminally ill or born with profound disabilities is becoming a controversial issue. The potential of medical technology, the practices of doctors and the expectations of parents have moved ahead of the law in this area. The interests of parents, children and medical practitioners would be better served by a clarification of the law. Legal change should be based on an ethical and moral foundation. The application of the "best interests" test should be given further consideration.

Australia↗
PubMed1990

Rejecting criminal liability for life-shortening palliative care.

Is it possible that a physician who administers life-shortening palliative care, even to a terminally ill patient with the patient's consent, commits murder? The Law Reform Commission of Canada, as part of its proposals on recodifying criminal law, has recommended that criminal liability not attach to the administration of life-shortening palliative care "appropriate in the circumstances." The author submits that while the aim of the Commission's recommendation is good, the phrase "appropriate in the circumstances" should be replaced with more specific criteria for determining when life-shortening palliative care may be administered. Failure to do so would leave physicians in almost as uncertain a situation as is presently the case, preventing them from administering such care without fear of criminal liability.

Adult↗
PubMed1989

From the editors.

Explore the source record for details and available documents.

Brain Diseases↗
PubMed2005

The failed complete repair of bladder exstrophy: insights and outcomes.

PURPOSE: We describe the complications of complete repair and their management. MATERIALS AND METHODS: A total of 19 patients were referred after failed complete repair. Total dehiscence occurred in 6 males, major bladder prolapse in 3, minor prolapse in 3, pubic separation in 1, impassable stricture in 1, and total hemiglans and corporal loss in 2. Overall, partial glans loss was seen in 7 patients, urethral loss in 5 and penile skin loss in 3. One female had complete dehiscence and 1 had major prolapse, both losing the urethrovaginal septum. One female had an impassable stricture. RESULTS: Six males with dehiscence underwent re-closure with osteotomy. Urethral replacement was performed with full thickness skin graft (FTSG) in 3 and with buccal mucosa in 3. Five patients underwent a modified Cantwell-Ransley (C-R) epispadias repair after placement of skin expanders, and 1 awaits repair. The 3 patients with major prolapse underwent re-closure with osteotomy. A urethral buccal graft was used in 1 patient, FTSG was used in 2 at a later operation and all 3 underwent C-R epispadias repair. Of the 3 patients with minor prolapse 2 underwent re-closure with osteotomy using urethral buccal graft or FTSG followed later with a C-R repair. The final patient with minor prolapse underwent re-closure with osteotomy and C-R repair after testosterone stimulation. One patient with pubic separation and urethral and skin loss underwent re-closure with osteotomy, C-R repair after skin expanders and later bladder neck repair. In 1 case a ureteral graft replaced a posterior urethral stricture. Of the 2 patients with hemiglans and corporal loss 1 underwent penile torsion repair and later hypospadias repair, while the other is being observed. Two females underwent re-closure with osteotomy and urethral replacement with tubularized bladder. The case of stricture was managed endoscopically. CONCLUSIONS: Complications of complete repair are similar to those of other repairs but more serious if soft tissue loss occurs. Because of these increased risks, this procedure and its formidable complications are best managed by experienced exstrophy surgeons.

Bladder Exstrophy↗
PubMed1996

Process changes and their effect on process evaluation for viral clearance.

The ability to remove and/or inactivate known and potential viral contaminants during the manufacturing process of a biological product has become an important parameter in assessing the safety of a biological product when it is produced from cell culture or from human or animal tissues. The combination of screening the starting material for infectious virus coupled with a process which will remove and/or inactivate significant levels of infectious virus has been demonstrated to be an effective way to assure product safety. A prime example of the application of this approach was in the manufacture of Factor VIII preparations which did not transmit HIV. Regulatory authorities have subsequently applied this model to a wide spectrum of tissue culture-derived products by requesting examination of the cell line for freedom from contamination with adventitious agents coupled with process evaluation. Difficult issues yet remain concerning agents which should be evaluated and what process changes should trigger a reassessment of the ability of the process to remove/inactivate virus. The broad issues of process changes and their potential effect on process evaluation will be discussed, including changes in the product, cell line, cell culture, manufacturing process, dosage and patient population. An initial process evaluation which is through and demonstrates robust removal and inactivation may obviate the need for re-evaluation of minor process changes.

Biological Products↗
PubMed1985

A revision of the N-terminal structure of sialoglycoprotein D (glycophorin C) from human erythrocyte membranes.

The amino-acid sequence of the N-terminal tryptic glycopeptide of a minor sialoglycoprotein (component D, glycophorin C) from human erythrocyte membranes was re-investigated and revised at the positions 12, 44, 47 and 48. Based on these and previous (Dahr, W. et al., Eur. J. Biochem. 125, 57-62, 1982) studies, the fragment exhibits the following structure (one-letter-code for amino acids, + = glycosylation): (Formula: see text).

Amino Acid Sequence↗
PubMed1998

Congenital skin loss following Nd:YAG placental photocoagulation.

This is the first reported case of congenital skin loss following endoscopic placental laser coagulation, a new technique for the ante-natal treatment of twin-twin transfusion syndrome. The skin defect healed rapidly after birth with dressings alone, mimicking the spontaneous re-epithelialisation of a minor burn wound or aplasia cutis congenita.

Burns↗
PubMed2006

Rhenium-mediated coupling of acetonitrile and pyrazoles. New molecular clefts for anion binding.

The reaction of fac-[ReBr(CO)3(NCMe)2] (1) with either pyrazole (Hpz) or 3,5-dimethylpyrazole (Hdmpz) in a 1:2 Re/pyrazole ratio affords the known complexes fac-[ReBr(CO)3(Hpz)2] (2) and [ReBr(CO)3(Hdmpz)2] (3). Using a 1:1 ratio, MeCN as solvent, and longer reaction times led to a mixture in which the major components are the pyrazolylamidino complexes fac-[ReBr(CO)3(HN=C(CH3)pz-kappa2N,N)] (4) and fac-[ReBr(CO)3(HN=C(CH3)dmpz-kappa2N,N)] (5). The complexes fac-[ReBr(CO)3(Hpz)(NCMe)] (6) and fac-[ReBr(CO)3(Hdmpz)(NCMe)] (7) (along with 2 and 3) were found to be minor components of these reactions. Analogous reactions of fac-[Re(OClO3)(CO)3(NCMe)2] yielded fac-[Re(NCCH3)(CO)3(HN=C(CH3)pz-kappa2N,N)]ClO4 (8), fac-[Re(NCCH3)(CO)3(HN=C(CH3)dmpz-kappa2N,N)]ClO4 (9), fac-[Re(Hpz)(CO)3(HN=C(CH3)pz-kappa2N,N)]ClO4 (10), and fac-[Re(Hdmpz)(CO)3(HN=C(CH3)dmpz-kappa2N,N)]ClO4 (11). The X-ray structure of 11 showed the perchlorate anion to be hydrogen-bonded by the N-H groups of the pyrazole and pyrazolylamidino ligands. The behavior of the compound fac-[Re(Hdmpz)(CO)3(HN=C(CH3)dmpz-kappa2N,N)]BAr'4 (13) (synthesized by reaction of [ReBr(CO)3(Hdmpz)2] (3) with (i) AgOTf and (ii) NaBAr'(4)/MeCN) as an anion receptor has been studied in CD3CN solution. In addition, the structure of the supramolecular adduct fac-[Re(CO)3(Hdmpz)(HN=C(CH3)dmpz-kappa2N,N)].Cl (14), featuring chloride binding by the two N-H groups, was determined by X-ray diffraction.

Journal Article↗