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Hyperthermic treatment of sporotrichosis: experimental use of infrared and far infrared rays.

We used pocket warmers and infrared and far infrared rays to treat 14 cases of sporotrichosis, 7 in children and 7 in adults. There were 9 cases of the fixed cutaneous type and 5 of the lymphocutaneous type; 6 were located on the face and 8 on the limbs. Four cases were treated with pocket warmers, 5 with infrared rays, and 5 with far infrared rays. All lesions treated with pocket warmers were facial lesions in children; infrared and far infrared ray treatments were used in 3 children and 7 adults, 2 on facial lesions and 8 on lesions on the extremities. In treatments with infrared and far infrared rays, the amount of heat was greater than with the pocket warmers, and one 15-min treatment daily was sufficient to yield satisfactory results, but this method is difficult to use on children and on the face, and 40-min treatments two or three times a week proved unsatisfactory. Infrared and far infrared ray treatments allow the length of a single treatment to be reduced by three-quarters, in comparison with one pocket warmer treatment.

Adult

[Effect of meat prepared by SHF energy and infrared rays on the secretory function of the stomach].

Tests set up on dogs with isolated Pavlov's pouch showed that meat treated with UHF, IR, UHF+UR-energy causes a more abundant gastric secretion than does cooked meat, and when processed with the UR-radiation the ensuing secretion is even superior to that in response to fried meat. In dogs with an isolated Heidenhein's pouch the secretion in response to meat processed with IR and IR and SHF+IR-energy is more intensive than in the case of cooked meat. There was no such difference in the case of the SHF-treated meat. Under the effect of the SHF, IR and SHF+IR-energy processed meat it is chiefly the I phase of the gastric secretion that gains in intensity with a tendency towards an increase in the II phase. The total acidity and the free HCl content in the gastric juice secreted in response to this meat did not undergo any substantial changes. The secretion of total proteinases with the gastric juice per unit time (1 hour) increases over that in the case of cooked meat.

Animals

Estimation of the degree of crystallinity in digoxin by X-ray and infrared methods.

The X-ray procedure for estimation of the degree of crystallinity in digoxin is based upon measurement of the total X-ray scattering and the scattering from crystalline regions of the drug. The infrared procedures are based upon measurement of the peak height ratios, 1775/1618 and 3095/1618 cm-1. Correlation between results obtained by the two methods is good. These methods are of value in the physico-chemical characterization of digoxin, particularly as the properties may be altered by comminution.

Chemical Phenomena

Intraoral infrared color photography of radiotherapy patients.

A clinical screening study was performed in which head-and-neck radiotherapy patients were photographed intraorally using infrared "false color" film and Ektachrome color film. These photographs were compared to determine if differences existed in appearance between the intraoral tissues within the field of radiation and those intraoral tissues not in the field of radiation. No differences could be detected with either the "false color" film or with Ektachrome color film. Further investigations in the use of infrared color photography as applied to the radiotherapy patient could be undertaken by using a light source that transmits infrared rays only and a lens filter that passes only infrared rays. This method would produce a film that shows only the reflected infrared rays. Both color and black-and-white film should be used in this study.

Color

The effect of grinding of human dentine examined by X-ray diffraction, infrared spectroscopy, and electron microscopy.

Analysis of human dentine by infrared spectrophotometry suggests that ball-grinding may result in damage of the apatite crystallites. The present study includes further assessments of this effect by X-ray diffraction, infrared spectroscopy, and electron microscopy. Each of three coarse-ground dentine samples (Group I) was divided into three portions of 30 mg. One of these portions was ball-ground for approximately 1 min (Group II), the second portion for 6 min (Group III), and the third portion for 23 min (Group IV). The 002 reflection showed line broadening, most marked from Group II to III. Electron microscopy showed a gradual change in crystallite appearance with increased grinding, most pronounced from Group II to III. These observations indicate that by prolonged grinding a limit is approached where no further changes in the crystallites occur. Electron microscopy also indicated that fracture of the crystallites might have occurred. This was probably accompanied by strains in the lattice. The infrared spectra indicated that no breakdown of the apatite structure had occurred during the entire grinding.

Apatites

Identification and differentiation between colored pencils.

With pencils of any color, the first step certainly involves visual examination to distinguish between the color tints and to study the quality of the stroke itself. In many instances by this step alone, 2 pencils can be distinguished if they are the product of 2 different manufacturers. In other words, the most useful of all tests is the visual examination. In the case of red pencils, infrared luminescence reveals significant information and should be resorted to in those instances where two questioned strokes are extremely similar. Study under ultraviolet radiation may also help to establish similarities or differences which are not readily discernible by visual examination. However, reflected infrared examination and study with dichroic filters have no particular value when dealing with red pencil although chemical spot testing may be of some assistance. In the case of blue pencils, a number of brands absorbs infrared radiation to a different extent and some give off distinctive infrared luminescence, so that these 2 tests can assist in distinguishing between certain similar colors or tints. Also, study through dichroic filters has value. Thus, the combination of these 3 tests can be of some advantage, but in most instances, particularly with dark blues, examination under ultraviolet radiation is not particularly helpful. Chemical spot testing has some limited advantages but generally only in combination with all other tests. In the case of green pencils, the same pattern of testing may be used as with blues. Many of the greens absorb infrared rays and some have bright infrared luminescence. Ultraviolet radiation can cause certain greens to fluoresce in a distinctive way. Thus, with each color studied, differences can be revealed and similarities established. Colored pencils are a distinct group of writing instruments. Within any color classification, there is a variety of shades or tints. Although it is not psosible to determine the make of pencil used in any particular writing, it is possible under many circumstances to distinguish between the work of different makes and grades of red, blue and green pencils, as well as other colors which have not been covered by this paper. While visual examination will separate the many different makes, other tests are described which will further assist in grouping or separating colored writing strokes. For a number of reasons, and particularly because of manufacturing procedures of different companies, not every make of pencil is distinctive, but there has been found to be a definite variety within each color group, and many makes are distinguishable.

Coloring Agents

[Effect of IR rays on the titers and protein fractions of the blood serum in chicks vaccinated with La Sota vaccine].

Studied was the effect of infrared rays on the titers and the protein fractions of the blood serum in birds treated with the La Sota vaccine. Results showed that the gamma-globulin fraction and the titers rise as established through the hemagglutination-inhibiton reaction. This made it reasonable to believe that the reticuloendothelial system was favourably activated as regards the immunogenesis against the Newcastle Disease virus. The rise in the gamma-globulin level coincides in time with the highest titer as found by means of the agglutination-inhibition reaction, the titers in all experiments being higher in the sera of the irradiated birds and the variations on the 20th day being mathematically significant.

Animals

The near-infrared electronic endoscope for diagnosis of esophageal varices.

We developed an electronic endoscope sensitive to light delivered by an infrared laser, which makes it possible to visualize submucosal vessels of the gastrointestinal tract. The system consists of a modified electronic endoscope and an image processing unit. A high output laser diode was chosen as the source of the infrared ray with a wavelength of 815 nm, an output of 200 milliwatts, and a band width of 30 nm. Using this instrument, esophageal varices were classified into three categories: venous dilation, dark spot, and diffuse dark area. The venous dilation and dark spot appearances correlated with early esophageal varices, which were rarely seen with visible light. On the other hand, the diffuse dark area appearance was considered to be a high risk sign of future bleeding. This system is useful not only for the early diagnosis of esophageal varices, but also for the localization of optimal puncture sites and the evaluation of the effect of sclerotherapy.

Adult

Clinical use of new video-endoscopes (EVIS 100 and 200).

The authors report on their clinical experience with two new videoendoscopes developed in cooperation with Olympus Co. One of them is an instantaneous image method videoendoscope (EVIS 100), the other produces sequential images (EVIS 200). EVIS 100 is as compact as a fiberscope; EVIS 200 has the special advantages of electronic magnification, the use of infrared rays and image display of hemoglobin concentration in the tissue. In clinical application in 245 patients examined with EVIS 100 and 30 cases with EVIS 200, both instruments were found to be satisfactory in terms of daily use; EVIS 200 could be applied in further endoscopic research. In our opinion videoendoscopes will replace conventional fiberscopes in the future.

Endoscopes, Gastrointestinal

[Dynamic telethermography in dermatology].

Dynamic telethermography permits direct observation of the emission of infrared rays from the skin of the human body. A certain number of dermatological diseases are liable to modify this emission and then show more or less localised hypo- or hyperthermia, e. g. malignant melanomas which represent the best indication for this new means of paraclinical investigation which has the advantage of being strictly atraumatic. The other black tumours of the skin, the skin carcinomas, certain hematodermias, cutaneous metastases and pre-cancerous conditions, radiotherapy lesions and burns, and hemangiomas may also benefit from this method. In fact, the latter may give some information on their degree of spread and their extension and response to treatment.

Basal Cell Carcinoma

[The role of thermography in the diagnosis of obliterating vascular diseases of the lower extremities].

The authors undertook comparative evaluation of the various methods of diagnosis of obliterative diseases of the lower limb vessels in 32 patients with II-III stage arteriosclerosis obliterans. Comparison of the results of arteriography, ultrasonic dopplerography, and objective examination with those of thermovision examination led to the conclusion that the method is valuable in revealing the condition of the collateral bed and microcirculation and the compensatory mechanism of circulation on the whole. In similar treatment in groups of patients formed according to the level of obliteration of the vessels and the thermographic picture, the best results were produced in those groups in which the intensity of the infrared rays was higher, which allowed the conclusion that thermography possesses not only diagnostic but also prognostic significance.

Aged

The effects of X-ray, ultraviolet and infrared irradiation on the basement membrane zone antibody reaction of the human skin in vitro.

Two patients with bullous pemphigoid were treated with radio cobalt or betatron irradiation. Thereafter bullous eruptions developed in the non-irradiated skin. It is known from the literature that ultraviolet light applied to the normal-appearing skin of patients with bullous pemphigoid produced fresh histologic and immunohistochemical changes in the irradiated skin. X-ray irradiation applied to human skin biopsy specimens using single doses of 7 000 and 8 000 R resulted in an increase of basement membrane zone antibody binding of 2-3 titre dilution steps. An increase of 3-4 titre dilution steps was achieved by irradiation with ultraviolet light. Infrared irradiation of skin biopsy specimens, on the contrary, caused the total loss of the basement membrane zone fluorescence. It merits further study, whether these contrary effects on the basement membrane zone antibody binding of human skin in vitro (activation of bound antigen after X-ray or ultraviolet irradiation and inactivation of antigen caused by infrared irradiation) are of clinical value concerning the bullous pemphigoid problem in vivo.

Aged

[Cystine calculi: x-ray diffraction study. Infrared spectroscopy and SEM].

The present study investigated cystinuria and cystine calculi. Inexplicably, of 987 calculi that had been analyzed ultrastructurally at the Department of Urology of the University Hospital of Salamanca over a period of 15 years only 3 (0.3%) were cystine. The foregoing finding does not coincide with the 0.5-1% incidence reported in the world literature. Apart from the chemical analyses, infrared spectroscopy disclosed the typical findings of multiple bands 1600-625 cm-1. Analysis by x-ray diffraction revealed a slight variation from the ASTM values. One of the calculi, which we considered to be a mixed calculus (probably of calcium phosphate), showed a peak at 43 degrees, instead of the usual 34.5. Scanning electron microscopy disclosed two forms of crystallization: The typical hexagonal form of cystine stones and the rectangular form of different sizes. The material comprising the matrix was observed in many areas, covering and joining the crystals as if it were cement. Whenever possible, treatment of these recurrent calculi should be conservative. Some advocate the use of ESWL, although others consider these calculi to be extremely hard and, therefore, not amenable to ESWL. Chemical dissolution is advocated by some, although its critics consider it to be of little use. Concerning prophylaxis, forced fluids and alkalinization may reduce recurrence. Ultrastructural studies have provided further insight into the structure and composition of cystine calculi. The foregoing may be useful in determining the most appropriate form of treatment based upon stone size, shape, composition (pure or mixed), etc.

Adult