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At least 19 recordsLinked to original sources
PubMed1977

Homologous artificial insemination. A reappraisal.

Homologous artificial insemination (AIH), with the use of a split-ejaculate technique, was performed in 62 couples following a complete infertility investigation. Fifty per cent of all men had a sperm count less than 50 million per milliliter and 80 per cent had sperm motility less than 50 per cent. More important, 85 per cent of the initial semen samples had greater than 40 per cent abnormal forms and liquefaction was delayed beyond 20 minutes in 67 per cent of specimen. The pregnancy rate for the 28 women who underwent the prescribed course of six or more inseminations was 46.4 per cent, for the group of 60 who received split-ejaculate AIH, 21.6 per cent; and for the entire group of 62 couples, 24.2 per cent. In the split-ejaculate group 50 per cent of the pregnancies resulted in first-trimester abortions. It is suggested that the pregnancy wastage in these couples might be due to male factors.

Abortion, Spontaneous↗
PubMed1977

Artificial insemination homologous and its role in the management of infertility.

Fifty-seven cases of homologous artificial insemination (AIH) were reviewed as well as the reason for performing the insemination. Three patients had AIH because of impotence, and two conceived. Twenty-nine patients whose husbands had sperm counts of less than 40 million/ml had AIH combined with split ejaculates, and seven (24.1%) became pregnant. Twenty-five patients had AIH because of persistent, unexplained, poor postcoital tests despite a normal semen picture, and eight (32%) became pregnant.

Erectile Dysfunction↗
PubMed1979

Artificial insemination homologous with oligospermic semen separated on albumin columns.

Semen samples obtained from 27 infertile men were separated on human serum albumin (HSA) columns prior to artificial homologous insemination (AIH). The columns contained either a single 7.5% HSA layer or two 17.5% and 7.5% HSA layers. Separated specimens were free of seminal debris, had significantly improved motility and progressive drive, and had a decreased percentage of abnormal forms. The total sperm count was also significantly decreased after separation, especially with the two-layer technique. No conceptions occurred in 21 couples when two-layer separation was used, but four pregnancies in 12 couples resulted from AIH with semen separated on the single-layer column. The mean total count of motile sperm obtained for AIH was 5 million with the two-layer and 31 million with the one-layer technique.

Adult↗
PubMedDate not supplied

Immunological usefulness of semen manipulation for artificial insemination homologous (AIH) in subjects with antisperm antibodies bound to sperm surface.

The authors report trials carried out in the preparation of semen for homologous artificial insemination in subjects with antisperm autoantibodies. The tests have demonstrated that swim-up is not able to select spermatozoa free of antibodies bound to the sperm surface. All the experiments of migration, dilution, antigenic competition and cryoconservation, carried out to evaluate the theoretical possibility of a better recovery of non "immunologically compromised" spermatozoa, have confirmed such negative results both with the Immunobead Test and Cytofluorimetric analysis.

Autoantibodies↗
PubMed1981

Homologous artificial insemination.

Artificial insemination--homologous (AIH) treatment in 100 couples is presented. An uncorrected pregnancy rate of 13% was achieved therapeutically versus a 10% spontaneous pregnancy rate. An adjusted pregnancy rate for those who conceived or completed at least six cycles of treatment was 41%. A pregnancy rate of 8% was obtained in 25 cases of oligospermia (less than 20 X 10(6)/ml), 15% in 27 cases of decreased motility only (less than 45% active), 27% in 18 cases of unexplained poor postcoital tests and 28% in 18 couples with suspected or proven immunologic problems. The most important reason for lack of success in our series appeared to be failure to continue therapy for an adequate period, defined as a minimum of six cycles. Since indications for AIH are less well defined than for artificial insemination with donor (AID), pregnancy yields are less reliable as an indication of a causal relationship.

Cervix Uteri↗
PubMed1987

Homologous artificial insemination for oligoasthenospermia: a randomized controlled study comparing intracervical and intrauterine techniques.

Homologous artificial insemination (AIH) is used to treat infertility caused by oligoasthenospermia, despite the lack of controlled studies confirming its benefit. This prospective randomized controlled trial was undertaken to determine whether intracervical (IC-AIH) or intrauterine (IU-AIH) homologous artificial insemination improves pregnancy rates in couples with infertility attributable to oligoasthenospermia alone. Twenty couples were randomized to receive IC-AIH or IU-AIH. Sixty-three insemination cycles were completed. During the same study period, 35 cycles with timed vaginal intercourse alone were assessed. Four pregnancies occurred, all following timed vaginal intercourse. No pregnancies resulted from IC-AIH or IU-AIH. This suggests that neither IC-AIH nor IU-AIH is of benefit when oligoasthenospermia is the cause of infertility. Pregnancies previously attributed to AIH may also have been conceived as a result of vaginal intercourse. This confounding effect on the results of AIH should always be considered.

Adult↗
PubMedDate not supplied

Homologous artificial insemination (AIH) and gamete intrafallopian transfer (GIFT) in Roman Catholicism and Halakhic Judaism.

While homologous artificial insemination (AIH) and gamete intrafallopian transfer (GIFT) can be viewed as compatible with the teachings of Roman Catholicism and Halakhic Judaism, their permissibility is much more strongly rooted in the latter. Nevertheless, AIH and GIFT cannot be dismissed as unacceptable to Roman Catholics, provided the semen is licitly obtained.

Catholicism↗
PubMed1976

Homologous artificial insemination and oligospermia.

Of approximately 339 patients evaluated at a private infertility service over a 5-year period, 24 couples underwent homologous artificial insemination (AIH). Nineteen of these were performed to circumvent the problem of oligospermia, and only one pregancy was achieved in this group; conceivably this pregnancy could have occurred by chance. The difficulty in controlling the numerous variables in a clinical fertility study and the limitations of the present methodology are also discussed. It would appear that the use of AIH to circumvent oligospermia has not been successful. However, the present series is rather small. AIH should continue to be offered to couples who have a well-defined indication such as impotence, premature ejaculation, or any anatomical defect which prevents successful intromission. The use of AIH for patients with mild oligospermia but excellent sperm motility probably deserves a limited trial, since it is less expensive and may offer some chance for success.

Adult↗
PubMed1981

Improved separation of motile sperm in asthenospermia and its application to artificial insemination homologous (AIH).

A method is described for the separation of motile sperm from semen by "migration' into a diluent, providing a large area of interface between the semen and the diluent and resulting in a good yield of motile sperm (58%), with a mean percentage of motility of 95%. The method provides a specimen free of seminal plasma and debris and suitable for intrauterine insemination in less than two hours. The motile fraction was used for AIH treatment of 20 couples with a mean of 4 years' infertility, where the female factor had been excluded and the male was asthenospermic. After a mean of six cycles, three pregnancies were achieved. Improvement of the percentage of motility alone did not, in this study, give a significant improvement in conception rates when compared with accepted cycles with the placebo.

Adult↗
PubMed1981

Homologous artificial insemination after long-term semen cryopreservation.

Although there are sporadic reports of pregnancies using semen after long-term cryopreservation, there are no data on the success rate of this procedure and its clinical feasibility. Between 1969 and 1980, 475 men deposited semen specimens prior to vasectomy or therapeutic sterilization. Prefreeze sperm counts and motility were significantly higher in the prevasectomy group. Later, 5 wives of 177 vasectomized men and 16 wives of 183 therapeutically sterilized men returned for artificial insemination with their husbands' semen. Only 1 conception resulted among the 21 women. This occurred after a single insemination of a 7-year-old specimen obtained prevasectomy. The post-thaw motility of this specimen (45%) was better than that of most other thawed specimens. Post-thaw motilities were unpredictable despite comparable prefreeze motilities. Because of this unpredictability, semen cryopreservation is clearly no guarantee of "fertility insurance".

Female↗
PubMedDate not supplied

Treatment of infertile couples by intrauterine artificial insemination homologous (AIH) of motile sperm collected by swim-up in human serum.

Twenty six couples with long standing infertility were treated by intrauterine AIH. Seminal and/or cervical factors were responsible for negative or poor coital test (PCT); retrograde ejaculation occurred in one case. A highly concentrated motile sperm suspension was obtained by swim-up procedure into fasting human serum and utilized for intrauterine insemination. Timing of ovulation was checked with the aid of ultrasound monitoring of follicular development. Totally, 120 cycles were treated. The pregnancy rate was 23.3%. Intrauterine AIH with motile sperm recovered by swim-up in human serum appears a valuable approach in the treatment of infertile couples with poor PCT as well as in cases of retrograde ejaculation.

Cell Separation↗