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At least 19 recordsLinked to original sources
PubMed1977

[Simultaneous determination of effective renal plasma flow and glomerular filtration rate using a double isotope technic--determination of the filtration fraction].

A method for the simultaneous determination of the effective renal plasma flow and of the glomerular filtration rate with the help of 131J-o-iodohippuric acid and 169Yb-DTPA using a double isotopic technique is described. Apart from this the method serves for the establishment of the filtration fraction. 40 patients with different clinical pictures (glomerulonephritis, pyelonephritis, cystic kidneys, stenosis of the renal artery) were examined. The clearance values established by us were in the areas characteristic for the clinical pictures. Pathological conditions could be established which are not yet characterized by an increase of the fixa of the urine in the serum. By the determination of the filtration fraction differential-diagnostically important insights are afforded. The examination is methodically simply to be performed and is of little stress for the patient. Therefore it seems to be suitable for the routine examination.

Glomerular Filtration Rate↗
PubMed1976

[Determination of the renal clearance in combination with isotope nephrography].

The possibilities of a determination of the renal clearance including the separation of sides with the help of simple nuclear-medical examination and measuring techniques are described. In 50 patients the determination of the effective flow of renal plasma was carried out with 131J-labelled iodohippuric acid. Methodic variants were compared. The examinations of the patient last one hour. They can be carried out in the outpatient department within the isotopic nephrography. In addition to this only several takings of blood samples are necessary. A catheterization of the urinary bladder as it is necessary for the classical determinations of the clearance is no more to be done. The results show that with the help of the methods described valuable quantitative informations about the function of the kidneys are to be got.

Glomerular Filtration Rate↗
PubMed1975

[Value of sequential scintrigraphy and clearance determination following normo- and hypothermic renal ischemia].

Using quantitative sequential camera scintigraphy and simultaneous separated clearance determinations with 131-I-Hippuran and 169-Yb-EDTA renal function was measured applying a new surgical method which permits in-situ kidney perfusion and cooling in animals and patients. While mongrel dogs of 15 kg average weight (control group of N = 5) showed after 1 hour of normothermic ischaemia a postoperative delay of intrarenal transport of 131-I-Hippuran with reduction of 131-I-Hippuran and 169Yb-EDTA clearances, renal function returned to normal on the first postoperative day after 1-hour (N = 5) and 2-hour (N = 5) hypothermic ischaemia. In patients (N = 9) with hypothermic in-situ perfusion of between 40 and 92 min duration a transient postoperative delay of intrarenal 131-I-Hippuran transport and a reduction of the 131I-Hippuran clearance was observed which returned to almost normal 1 1/2 to 3 months after surgery. The results and the significance of the method discussed and are compared with clinical findings and with radiological and laboratory renal function studies.

Animals↗
PubMed1979

[Investigations on 131I-hippurate-clearance in obstructive-uropathy; extraction of para-aminohippuric acid and 131I-hippurate in the acutely obstructed canine kidney (author's transl)].

The results of more recent clinical and experimental investigations have thrown doubt on the usefulness of determining the individual 131I-hippurate clearance for evaluation of the function of acutely obstructed kidneys. There is a significant difference (5% level) between the kidney performance determined with external measurement on the one hand and with PAH and 125I-hippurate clearance in the steady state on the other. With the steady state method, the restriction of function to be expected in consequence of urinary obstruction is demonstrated, whereas with simultaneous measurement with catheterless 131I-hippurate clearance, an increase in function is detected. In the clearance studies carried out in the conventional way with PAH and 125I-hippurate, it was difficult to determine quantitatively the urine produced during urinary obstruction. The renal extraction of p-aminohippuric acid and 131I-hippurate was therefore determined in simultaneous measurement in six dogs before and after acute urinary obstruction with a constant plasma level of the test substances. The results obtained with this very elaborate method which is, however, independent of urine collection show that an acute urinary obstruction leads to a decrease of renal extraction both of PAH and of 131I-hippurate. Since with conventional clearance, the measurement result is proportional to the amount of substance excreted with the urine, a restriction of function must also result with the steady state methods in determining the performance of acutely obstructed kidneys. The results of the extraction investigations hence confirm the results of the clearance studies mentioned. In addition, they show that the "increase" of renal performance immediately after an experimentally induced urinary obstruction repeatedly found with catheterless determination of 131I-hippurate-clearance cannot be explained by a different kinetic behavior of PAH and 131I-hippurate in the acutely obstructed kidney.

Acute Disease↗
PubMed1977

Selectivity of food colours for different organic acid transport systems in rat renal cortex.

Seventeen food colours were tested as inhibitors of the simultaneous uptake of labelled o-iodohippurate and iodipamide into slices of rat renal cortex. The results have been interpreted in terms of inhibition of two different aniontransport systems: the hippurate of H-system and the liver-like L-system. No clearcut relation was found between inhibition ability and system specificity on the one hand and moleculr weight or structure on the other. However, most disulphonic azo dyes and quinoline yellow show an L-system affinity while tri-and tetra-sulphonic azo dyes, triarylmethanes and erytrosine show very little predilection for either of the two systems.

Animals↗
PubMed1976

[Clinical possibilities of a method for the simultaneous determination of the GFR and the ERBF using a "cocktail" of 169 EDTA and 125I-hippuran].

The results are discussed obtained from 198 patients with the two most frequently met kidney diseases--chronic glomerulonephritis and pyelonephritis, with a total of 396 renal clearance tests. In 65.7 per cent of the patients with chronic glomerulonephritis decreased values of blomerular filtration (GF) and the renal flow effect (RFE) were established, with a parallel decrease in both clearances in 56.5 per cent and isolated disturbances of GF in 31.9 per cent and of RFE in 11.6 per cent. In the patients with chronic pyelonephritis a parallel decrease of GF AND RFE was found in 66.7 per cent and isolated disturbances of GF in 13.6 per cent and RFE--in 19.7 per cent. The high percentage of parallelly decreased GF and RFE reveals the sensitivity of the method in the diagnosis of early renal functional alterations while the application of only one of the clearances might not detect the existing alterations. The results from the carried out comparative investigations between the isotope clearances and isotope nephrography with 131I--hippuran are also reportentage of the depuration radioisotope tests as compared with ING in the detection of early renal functional laterations. Radiation risk is rendered to a minimum with the use of the "cocktail" of 169U-EDTA and 125I-hippuran.

Adolescent↗