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Results for “KIMMELSTIEL-WILSON SYNDROME”

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At least 19 recordsLinked to original sources
PubMed1983

Histopathology of argon laser photocoagulation in juvenile diabetic retinopathy.

A 24-year-old woman had insulin-dependent juvenile diabetes for 15 years. She developed Sheehan's syndrome (postpartum pituitary necrosis) and diabetic nephropathy at 20 years of age. She had multiple sessions of argon laser photocoagulation for proliferative diabetic retinopathy. Histologically, loss of outer retina and pigmented epithelium occurred at the laser sites. Trypsin retinal digest preparations revealed microaneurysms and markedly decreased numbers of pericytes. The kidneys displayed nodular glomerulosclerosis (Kimmelstiel-Wilson syndrome). The anterior pituitary showed cystic degeneration and old hemorrhage.

Adolescent↗
PubMedDate not supplied

[Indicators of phagocytic activity of neutrophils in patients with diabetes mellitus before and after treatment using the "Biostator"].

Phagocytic function of polymorphonuclear leukocytes was studied in patients with insulin-dependent and insulin-independent diabetes. A total of 52 patients were examined; the patients were mainly young, suffering from insulin-dependent diabetes with or without angiopathies. The leukocyte phagocytic activity was studied with the use of the direct method developed by G. I. Podoprigora and V. N. Andreev in 1976. All phagocytosis parameters were shown to be reduced, the relationship between these parameters distorted, and digestion impaired, especially in patients with diabetic functional angiopathy and with the Kimmelstiel-Wilson syndrome. A trial is described of correcting phagocytosis disorders by means of a Biostator apparatus (an artificial pancreas, functioning according to the feedblack principle). Such investigation was the first attempted in this country, no data on the leukocyte phagocytic activity before and after treatment with the use of an artificial pancreas apparatus were reported in foreign literature. Clinical application of the method is described.

Adolescent↗
PubMedDate not supplied

Diabetic nephropathy and proliferative retinopathy with normal glucose tolerance.

A 61-yr-old man presented with the nephrotic syndrome and normal oral glucose tolerance. Renal biopsy showed the nodular (Kimmelstiel-Wilson) and diffuse glomerulosclerosis lesions characteristic of diabetes. Direct ophthalmoscopy and fluorescein angiography demonstrated a picture of advanced proliferative diabetic retinopathy. The patient had no history of diabetes mellitus and upon testing had normal glucose values in response to an oral glucose tolerance test. Insulin response to an intravenous glucose tolerance test was abnormally low. It is concluded that the nodular glomerulosclerosis lesions and proliferative retinopathy, thought to be specific for diabetes mellitus, may present in the absence of either overt clinical diabetes or impaired glucose tolerance.

Blood Glucose↗