SEARCH · PubMed Health

Results for “Kitasamycin”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 19 recordsLinked to original sources

PubMed1990

Pharmacokinetics and tissue residues of kitasamycin in healthy and diseased broilers.

The pharmacokinetics of kitasamycin after intravenous and oral administration in a dose of 300 mg/kg b.wt. was studied in 18 healthy and 18 Salmonella gallinarum naturally infected chickens. The tissue residue of the studied antibiotic was estimated in 36 normal chickens when it was given orally for 7 successive days. Therapeutic level of kitasamycin was achieved after 15 minutes and persisted for 20-22 hours after its oral administration. Higher serum kitasamycin concentrations were recorded in Salmonella gallinarum infected chickens. The elimination half-life of kitasamycin calculated after single intravenous injection was 9.03 hours in diseased chickens corresponding to 3.74 hours in healthy birds. The body clearance was significantly reduced in diseased chickens (23.86 ml/kg/min) when compared to that in normal ones (62.03 ml/kg/min). Kitasamycin treated broilers should not be slaughtered before 3 days from the last dose as it was detected only in bile and caecum at that time but not in edible tissues.

Animals↗

PubMed1979

Biosynthesis of kitasamycin (leucomycin) by leucine analog-resistant mutants of Streptomyces kitasatoensis.

The biosynthesis of kitasamycin in Streptomyces kitasatoensis B-896 was profoundly influenced by the addition of precursors to complex and defined media: l-valine and l-leucine directed biosynthesis towards the pairs A(4)/A(5) (R(2) = butyryl) and A(1)/A(3) (R(2) = isovaleryl), respectively, and total kitasamycin titers were doubled and quadrupled, respectively. S. kitasatoensis B-896 was very resistant (>20 mg/ml) to alpha-aminobutyric acid, an analog of l-valine, but very susceptible to l-leucine analogs 5', 5', 5'-trifluoroleucine and 4-azaleucine (5 to 10 mug/ml). The inhibition by 4-azaleucine could be reversed by l-leucine, but by none of the other amino acids of the pyruvate family or the amino acids of the aspartate pathway. 4-Azaleucine-resistant mutants were isolated which in the absence of any precursors overproduced l-leucine and a kitasamycin complex mainly consisting of the pair A(1)/A(3). These 4-azaleucine-resistant mutants are presumed to be regulatory mutants in which alpha-isopropylmalate synthase, the first enzyme of the l-leucine pathway, has become either derepressed or desensitized to leucine feedback inhibition. l-Leucine-regulatory mutants have economic value: in the absence of expensive precursors, they produce a kitasamycin complex in which the most potent pair A(1)/A(3) is dominant and the least active components are absent.

Anti-Bacterial Agents↗

PubMed1994

[Development and investigation of preparations containing kitasamycin and flumequine].

Swine dysentery and poultry cholera are very harmful animal diseases which cause great damage. Flumequine and kitasamycin are new and up-to-date preparations for the treatment of these diseases. ++ Imequyl ad us. vet. and ++ Trubin ad us. vet. are the registered medicines. The doses are 7 mg flumequine and 21 mg kitasamycin/body weight kg. The drug technological problem is that flumequine does not dissolve sufficiently in water. It dissolves well at pH = 10, but kitasamycin is unstable at this pH. It was hoped that these two components would together act as agonists, and that kitasamycin would promote the dissolution of flumequine. An injection preparation and a powder mixture for dissolution were developed. Chemical interaction between the components was conformed by IR and NMR measurements.

Animals↗

PubMed1988

[Immunomodulator effects of 2 antibiotics, chloramphenicol and kitasamycin, in the chicken].

One-day-old chickens treated via drinking water with kitasamycin (0.7 g/l for 6 days then 0.35 g/l for 15 days) or with chloramphenicol (1 g/l for 6 days the 0.5 g/l for 15 days), were immunized at the 24th day with sheep red blood cells. Body and spleen growths were recorded and compared to control every week for 5 weeks after immunization. Humoral and cell-mediated immune responses were measured by hemagglutinating antibodies titration, direct and indirect plaque forming cells (PFC) numeration, and graft versus host reaction (GVHR). Both antibiotics reduce antibody response and number of PFC, chloramphenicol being significantly more suppressive than kitasamycin. A short stimulation of cellular response is shown with kitasamycin, which stimulates GVHR, whereas chloramphenicol has a negative effect.

Animals↗

PubMed1990