[Lambliasis in infants and clinical picture of lambliasis].
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Multiple biopsies from the lower duodenum were obtained during endoscopy of 171 patients with dyspepsia, diarrhoea and/or suspected malabsorption. Histological evidence of lambliasis was obtained in six (3.5%). Antibiotic treatment with metronidazole, 250 mg two or three times daily for seven to 11 days (which had to be repeated in two cases), improved symptoms in four. In most of the patients "functional upper-abdominal symptoms" had been diagnosed after extensive examinations. In case of unclear upper-abdominal symptoms, chronic or chronic-recurrent diarrhoea and/or malabsorption lambliasis should be considered and histological examination of the duodenal mucosa undertaken.
A total of 276 patients with taeniasis alone and taeniasis associated with enterobiasis or lambliasis were involved in the study. The most prevalent features in patients of all the three groups were combinations of the painful, dyspeptic and astheno-vegetative syndromes, the least so--an isolated astheno-vegetative syndrome. Combinations of these syndromes more frequently occur in taeniasis concomitant with enterobiasis (61% vs. 51% in taeniasis alone). Associations of taeniasis with enterobiasis or lambliasis are more frequently diagnosed in children. Combinations of the three syndromes were revealed in the patients with taeniasis coursing against the background of chronic gastritis, duodenal ulcer, cholepathies: in 79% vs. 33.3% in an uncomplicated course. Fenasal therapy for 3 days in a daily dose of 3 g proved fairly effective: 85.7 +/- 6.3% of adults and 82.6 +/- 6.4% of children recovered.
Owren's disease is a rare hemorrhagic diathesis which can occur in infancy as a severe hemorrhagic disorder. It also appears in adult life when clinical manifestations are those of acquired deficiencies of other coagulation factors. A familial survey enables a definite diagnosis to be made as it demonstrates the presence of deficiency in factor V in one or several members of the family. Such a case is reported in a young adult with an associated intestinal malabsorption syndrome due to lambliasis. After administration of vitamin K the deficiency in factor V remained an isolated disorder, and the hemostatic anomaly was found in three other members of the family. The deficiency was a partial one, which explains why the Owren's disease only became evident during the course of the malabsorption syndrome due to lambliasis which caused a reduction in the level of vitamin K dependent factors II, VII, and X.
The data on the clinical trials of the antiprotozoan agent tridazole-500 are presented. Drug parasitocidal activity and tolerance have been determined. The treatment was performed in 31 patients with lambliasis. A satisfactory drug tolerance and a 77.4% efficacy have been established.
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