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Protection against acute ethanol toxicity in mice by zinc aspartate, glycols, levulose and pyritinol.

The lethality in mice after an acute intraperitoneal challenge with ethanol could be largely prevented by treatment with single doses of zinc aspartate. Other zinc salts or aspartates were not or clearly less effective than zinc aspartate. Marked protection was also provided by polyethylene glycol and propylene glycol. The antagonistic effects of levulose and pyritinol against acute ethanol intoxication were confirmed.

Alcoholic Intoxication↗

[Behavior of the metabolism in gastric patients during a 4-day-long postoperative complete parenteral feeding with amino acids and a glucose-levulose-xylitol combination solution].

In a clinical study we tested the following parameters: free fatty acids, beta-hydroxybutyrate, acid-base-balance, lactate, bilirubin, uric-acid, fructose, xylitole, glucose in blood and urine. The tests were executed in 9 patients who were undergoing stomac operations. The cardio pulmonary system of all patients was normal, and there was a homeostasis in water and electrolytes preoperatively. In combination with the amino-acids we received a ratio of 1:1:1 for glucose, levulose and xylitole. Totally, the patients received 0.36 g per kg body weight and per hour of carbohydrates. Beta-hydroxybutyrate, aceto-acetat, and free fatty acids show normal values under conditions of parenteral nutrition as well as lactate, uric acid, and acid-base-balance. The ratio of the different carbohydrates in serum and urine prove that the infusion time and volume were extremely favourable. The loss of carbohydrates in urine was very low.

Acid-Base Equilibrium↗