SEARCH · PubMed Health

Results for “LIPOIDOSIS”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 19 recordsLinked to original sources

PubMed1985

[Intimal lipoidosis of the coronary arteries of newborn infants and infants in the 1st year of life].

Post-mortem morphological examination of the coronary arteries in 76 newborns and children of the first year of life was performed. Cases of the cardio-vascular pathology were not included into the study. Intimal thickening, either diffuse or focal, was revealed in 58 cases. The degree and frequency of the diffuse thickening of the intima (DTI) were higher in boys. DTI was present predominantly in the anterior interventricular artery and much less frequently in the circumflexal coronary artery. Intimal lipoidosis was found un 21 cases, with the same incidence in both boys and girls, but somewhat more frequently in the right coronary artery. Topography of both intimal lipoidosis and DTI was similar. The traces of cholesterol, its esters and predominantly neutral fat were defected histochemically in the foci of intimal lipoidosis.

Coronary Disease↗

PubMedDate not supplied

[Behaviour of the aortic lipoidosis in rats twenty months after stopping of an hyperlipidic diet (author's transl)].

48 rats were placed on an hyperlipidic diet (cholesterol, cholic acid, cholin, propylthiouracil), 23 were sacrificed at various intervals from the fourth up to the twelve month of the experiment. In the remaining 25 rats, the atherogenic regimen was replaced by a normal one. These animals were sacrificed one to twenty months after stopping of the experimental diet. Aortae of experimental and control animals were studied by means of histological and histochemical technics. All the animals developed hypercholesterolemia together with intima and media lipoidosis. None demonstrated any aortic cell proliferation. The only metabolic change of the smooth muscle cell was a progressive decrease in 5' nucleotidase, acid esterase and cholinesterase activities. The return to a normal diet involved the reversion of the serum cholesterol level to normal values and the disappearance of intima lipoidosis. The reduced enzymatic activities in the media returned to normal levels around the sixth month. The surfaces of the extracellular sudanophilic areas decreased. However, twenty months after stopping of the atherogenic diet, some lipids still persisted at the edges of the elastic fibres.

Animals↗

PubMed1980

[Behaviour of the aortic lipoidosis in rats twenty months after the withdrawal of an hyperlipidic diet (author's transl)].

48 rats were placed on an hyperlipidic diet (cholesterol, cholic acid, cholin, propylthiouracil), 23 were sacrificed at various intervals from the fourth up to the twelve month of the experiment. In the remaining 25 rats, the atherogenic regimen was replaced by a normal one. These animals were sacrificed one to twenty months after the withdrawal of the experimental diet. Aortae of experimental and control animals were studied by means of histological and histochemical technics. All the animals developed hypercholesterolemia together with intima and media lipoidosis. None demonstrated any aortic cell proliferation. The only metabolic change of the smooth muscle cell was a progressive decrease in 5' nucleotidase, acid esterase and cholinesterase activities. The return to a normal diet involved the reversion of the serum cholesterol level to normal values and the disappearance of intima lipoidosis. The reduced enzymatic activities in the media returned to normal levels around the six month. The surfaces of the extracellular sudanophilic areas decreased. However, twenty months after the withdrawal of the atherogenic diet, some lipids still persisted at the edges of the elastic fibres.

Animals↗

PubMed1967

Clinical and electron microscopic studies of a case of glycolipid lipoidosis (Fabry's disease).

A case of glycolipid lipoidosis (Fabry's disease) in a 27-year-old man is recorded. The case is unusual in that despite extensive disease evidenced by widespread skin lesions, ocular abnormalities, and proteinuria, renal function was only minimally impaired. Electron microscope studies of kidney and skin showed that most cells contained the characteristic lipid described in this condition.

Adult↗

PubMed1984

Erdheim-Chester disease: a distinct lipoidosis or part of the spectrum of histiocytosis?

Erdheim-Chester disease has always been considered a distinct lipoidosis based on clinical and radiographic criteria. Pathologically, it has been indistinguishable from Hand-Schüller-Christian disease. Analysis of the 15 reported cases lends some doubt as to the diagnostic criteria. A new case is presented that strongly suggests that Erdheim-Chester disease is actually part of the spectrum of the histiocytoses.

Adult↗

PubMed1976

[Sphingomyelin lipoidosis (author's transl)].

The case of a girl is described who was 3 1/4 years of age and was admitted of the hospital because of hepato-splenomegaly. In addition to this, there were peculiar alterations in the lungs, an increase of lipoids in the blood, a characteristic alteration of the retina, and bone marrow and liver cells storing lipoid. The diagnosis of sphingomyelin lipoidosis (Niemann-Pick) was confirmed by electronmicroscopic and biochemical investigation of a percutaneous liver biopsy specimen.

Bone Marrow↗

PubMed1955