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Results for “LUPUS ERYTHEMATOSUS, DISSEMINATED”

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At least 19 recordsLinked to original sources
PubMedDate not supplied

[Neuropsychiatric and vascular manifestations of disseminated lupus erythematosus].

Disseminated lupus erythematous is an auto-immune disease with systemic manifestations that develops by outbreaks. It's pathogenesis is unknown. The physiopathology jeopardizes auto-immune phenomenon whose most important biological effect is the polyclonal activation of B Lymphocytes. The tissue's lesions are due to several mechanisms, being, perhaps, the deposition of immune complexes of a great value. On account of a young woman with recurrent deep venous thrombosis and neuropsychiatric manifestations the bibliographic data are reviewed, especially those that concern with the etiopathogenesis, treatment and prognosis.

Adolescent↗
PubMedDate not supplied

[Thrombosis in disseminated lupus erythematosus].

In the course of disseminated lupus erythematosus (DLE), the development of arterial or venous thrombosis is sometimes observed. They are rare in the course of hematological forms of DLE, in which the more or less constant leucopenia is accompanied to variable extent by the affection of the other blood-lines: thrombocytopenia and/or thrombocytopathy and/or hemolytic anemia. The discovery of a circulating anticoagulant seems to be correlated with the existence of thrombosis. In fact it involves antiphospholipid antibodies, responsible for the protraction of certain coagulation tests, which shows up their existence. Recent studies have shown recognition of the membrane phospholipids of the vascular endothelial cell. A functional imbalance in this would be observed to encourage the synthesis of factors favorable to thrombosis.

Abortion, Spontaneous↗
PubMed2004

[Myocardial infarction and disseminated lupus erythematosus].

Myocardial infarction is an underestimated complication of disseminated lupus erythematosus (DLE). Its features, treatment and prognosis are poorly understood. From June 1988 to December 2002, out of 1572 consecutive patients admitted during the first hours of acute myocardial infarction with ST elevation, 7 (5 women, aged 38 +/- 7 years) had DLE. The commonest risk factor was smoking (N = 4). There was a higher incidence of anterior infarction (N = 5). The infarct occurred 7 +/- 5 years after diagnosis of DLE. There were other complications of DLE in all cases. Three patients had antiphospholipid syndromes. The culprit artery was usually the left anterior descending (N = 5). The lesions included stenosing atheroma (N = 5) and extensive thrombosis (N = 5). The coronary disease was usually limited to a single vessel (N = 5). Revascularisation procedures include pre-hospital thrombolysis (N = 3) followed by immediate angioplasty (N = 2) or primary angioplasty (N = 4). TIMI grade 3 flow was obtained in all cases, 278 +/- 162 min after the onset of symptoms. The clinical course was characterised by acute reocclusion in 3 patients, recurrent in 2 patients with an antiphospholipid syndrome, and death in 1 case. Acute myocardial infarction occurs in already complicated cases of DLE, in young patients, associating atherosclerosis and extensive thrombosis. The risk of early reocclusion after reperfusion is high, especially in cases with the antiphospholipid syndrome.

Adult↗
PubMed1981

[Acute chorea and disseminated lupus erythematosus (author's transl)].

A case of acute chorea in a young woman with disseminated lupus erythematosus is described and 27 similar cases reported in the literature are reviewed. As in other neurological complications of the disease, signs of diffuse, labile angeitis (dysoric nodules) were present as well as antilymphocyte antibodies characteristics of these forms. Acute chorea is however a rare finding when compared with other types of complications. It keeps its clinical picture resembling that of Sydenham's chorea, and with which is can be compared also as regard the immunological syndromes frequently observed in acute rheumatic fever, and that which occasionally occurs during disseminated lupus erythematosus.

Adult↗
PubMed1981

Annular vesicular lupus erythematosus.

Disseminated cutaneous lupus erythematosus is a recently defined variant of lupus erythematosus. It presents as migratory areas of annular erythema, but lacks the atrophy, scarring, and follicular plugging associated with discoid lupus erythematosus. The clinical manifestations of this disease fall somewhere in between those associated with classic discoid lupus erythematosus and those associated with systemic lupus erythematosus. A case of disseminated cutaneous lupus erythematosus occurring in a 91-year-old woman is presented. This patient developed areas of subepidermal cleavage resulting in clinically apparent flat vesiculation with subsequent crusting and erosion. Lupus erythematosus must be considered in the differential diagnosis of migratory annular erythema with or without vesiculation.

Aged↗
PubMed1977

[Malignant lymphopathy in a patient suffering from acute disseminated lupus erythematosus (author's transl)].

The authors report a case of acute disseminated lupus erythematosus in a 55 years old patient, receiving small doses of corticosteroids, progressing over three years. During an acute exacerbation of the disease, the development of a cervical adenopathy led to a biopsy. Histological examination revealed a lymphocytic type malignant proliferation (centro-follicular lymphoma). This case is compared with findings reported in the literature and leads to a discussion of the relationship between ADLE and malignant disorders due to a disturbance of immune control mechanisms and the possible role of immune-depressant therapy in their onset.

Chlorambucil↗