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At least 19 recordsLinked to original sources
PubMed1975

[Development of resistance in Fisher lymphadenosis cells to dipin and bruneomycin when these preparations are used separately and in combination].

It was shown that dipin and bruneomycin resistant tumor cells appeared in mice with transplanted lymphadenosis after 10 passages on single use of the drugs. When the drugs were used in combination, no lymphadenosis cells resistant either to bruneomycin, or to dipin and their combination were found. The combined use of the drugs prevented development of resistance to them in the lymphadenosis cells at least during 10 passages on mice. The data on the possible prevention of the resistance development in the mouse lymphadenosis cells by means of combined use of low doses of dipin and bruneomycin provided an assumption that it is expedient to test the combination in clinics.

Alkylating Agents↗
PubMed1976

[Chronic lymphadenosis--short review].

It was tried to show in form of a survey some molecular-biological, immunopathological and kinetic aspects of the CL (chronic lymphadenosis)-lymphocytes, which seem to be significant for the pathogenesis of chronic lymphadenosis. Apart from this, the modern therapeutic possibilities concerning the inhibition of proliferation as well as the depletion which seem to be suitable for influencing the still fatal course of chronic lymphadenosis are discussed.

Antibody Formation↗
PubMedDate not supplied

Effect of N-nitrosomethylurea on substrains of Fisher lymphadenosis L-5178 resistant to antitumoral antibiotics.

A cytogenetic analysis of variants of Fisher mouse lymphadenosis L-5178 resistant to the antitumoral antibiotics bruneomycin and rubomycin C showed that the cytogenetic characteristics of the changes in the tumor cell population correlate with the chemotherapeutic indices of the development of drug resistance. Cytogenetic and kinetic analyses showed that variants of Fisher lymphadenosis L-5178 resistant to bruneomycin and rubomycin C retain sensitivity to N-nitrosomethylurea (NMU). The activity of NMU in an experiment on resistant substrains of lymphadenosis can serve as a basis for the clinical use of NMU in the treatment of lymphomas resistant to antibiotics.

Animals↗
PubMed1995

Lymphoproliferative responses to Borrelia burgdorferi in patients with erythema migrans, acrodermatitis chronica atrophicans, lymphadenosis benigna cutis, and morphea.

BACKGROUND AND DESIGN: Specific humoral and cell-mediated immune responses play an important role in the pathogenesis of Lyme borreliosis. Several previous studies demonstrated that a specific cellular immune response to Borrelia burgdorferi can occur independently of a diagnostic humoral response. Little is known about T-cell reactivities against B burgdorferi in early and late cutaneous manifestations of Lyme borreliosis. We studied the lymphoproliferative response of peripheral blood mononuclear cells to B burgdorferi antigen from 99 patients (25 with erythema migrans, 16 with acrodermatitis chronica atrophicans, 13 with lymphadenosis benigna cutis, and 45 with localized scleroderma) and 21 control subjects. The results are expressed as a stimulation index (SI) (mean count per minute of triplicate cultures with stimulant divided by mean count per minute without stimulant). The serum samples from all patients and control subjects were tested for antibodies to B burgdorferi by indirect immunofluorescence assay. RESULTS: The 21 healthy seronegative controls had an SI of 3.3 +/- 2.0 (mean +/- SD). Compared with that of control subjects, the SIs were significantly elevated in patients with erythema migrans (9.8 +/- 9.1), acrodermatitis chronica atrophicans (11.8 +/- 8.2), and lymphadenosis benigna cutis (7.2 +/- 6.2). The 45 patients with localized scleroderma had elevated proliferative responses, with an SI of 6.5 +/- 7.3, but these responses did not significantly differ from those of controls. Elevated titers of antibodies to B burgdorferi were present in six (24%) of 25 patients with erythema migrans, five (38%) of 13 patients with lymphadenosis benigna cutis, and 13 (29%) of 45 patients with localized scleroderma. All 16 patients with acrodermatitis chronica atrophicans had markedly elevated antibody titers. CONCLUSIONS: Our findings show that a significant lymphoproliferative response to B burgdorferi occurs in the majority of patients with cutaneous manifestations of Lyme borreliosis. The lymphocyte proliferation assay may be of diagnostic value in patients in whom Lyme borreliosis is strongly clinically suspected and who have nondiagnostic levels of antibodies against B burgdorferi.

Acrodermatitis↗
PubMed1994

[The immunophenotypic lymphocyte analysis of orbital lymphadenosis and its significance].

An immunophenotypic lymphocyte analysis of 56 cases of orbital lymphadenosis was performed with a panel of 10 monoclonal antibodies against the lymphocyte differentiation antigen by the streptavidin-peroxidase conjugate method to reveal that (1) all 15 cases of inflammatory pseudotumor and 32 of 33 cases of reactive lymphocyte hyperplasia manifested polyclonality of the constituent cells; (2) the immunophenotype of cells was monoclonal in 2 of 3 cases of atypical lymphocyte hyperplasia and diagnosis of malignant lymphoma (ML) were established; and (3) among 5 cases of ML, the cells were shown to be B-cells in 4 cases and T-cells in 1 case. These results suggested that immunophenotyping could be useful in differentiating the benign from the malignant orbital lymphadenosis and the histologic types of ML. The relationship between pathologic and immunologic classifications of orbital lymphadenosis was also discussed.

Diagnosis, Differential↗
PubMed1985

Immunocytoma of the skin simulating lymphadenosis benigna cutis.

We report a case of primary cutaneous lymphoma, of the lymphoplasmacytoid type (immunocytoma), in which a small neoplastic component was obscured by a dominating reaction exhibiting characteristic features of lymphadenosis benigna cutis. This abnormal cell population was identified because of the unusual cytomorphology of the tumor cells, which showed deeply indented nuclei in combination with a distinctly plasmacytic cytoplasm. Monoclonality was revealed by the cytoplasmic positively of the tumor cells for lambda chains only. This case strongly suggests that in at least a number of cases of lymphadenosis benigna cutis, a low-grade malignant lymphoma may be present.

Adult↗
PubMed1985

A morphologic study of lymphadenosis benigna cutis.

Two skin biopsies of lymphadenosis benigna cutis have been analyzed by morphological and immunological methods using monoclonal and polyclonal antibodies on cryostat and paraffin sections. Follicular structures containing active germinal centers are composed of identical cell types as germinal centers of normal lymphatic tissue, e.g. centrocytes, centroblasts, immature plasma cells, dendritic reticulum cells and some T lymphocytes. Outside and inbetween the secondary follicles the infiltrate is composed of small T lymphocytes (OKT-3+, focal positive acid phosphatase reaction). Among T lymphocytes the OKT-4+ to OKT-8+ ratio was 2:1. Within these areas, consisting almost exclusively of T lymphocytes, cells with electron microscopical features of indeterminate cells and interdigitating reticulum cells were recognized. Those cells are OKT-6+. It can be concluded that in lymphadenosis benigna cutis the infiltrate of the dermis is composed of B and T cell areas which show the same microarchitecture and morphology as in normal lymphatic tissue.

Antibodies, Monoclonal↗
PubMed1976

[Study using the probit-analysis method of the process of increasing resistance to dipin and bruneomycin in Fisher L-5178 lymphadenosis cells in experiments on animals].

The study of the process of resistance induction in the cells of lymphadenosis to dipin (subline L-5178/D) and bruneomycin (subline L-5178/B) showed that with increasing of the resistance relation between the drug dose and the antitumor effect gradually faded. It was found that only at the first stages of induction of the resistance increase may be found by comparison of values ED50 and ED70 of the lymphadenosis sensitive strain and its resistant sublines. The probit-analysis method provided registration of the resistance increase also at later stages. In this case the resistance level may be estimated by the slope of the dose-response curve.

Animals↗
PubMed1977

[Development of bruneomycin and rubomycin resistance in mouse lymphadenosis tumor cells and Staphyloccus when these preparations are used separately or together].

Two sublines of mouse lymphadenosis (L-5178) resistant to bruneomycin and rubomycin used alone, as well as a subline with induced resistance to the combination of these drugs were employed in the study. The studies showd that in separate use of rubomycin and bruneomycin the tumor cell resistance to the respective drug was evident at the 10th passage. After 30 passages neither bruneomycin nor rubomycin produced reliable inhibition of the tumor growth in the respective subline of lyphadenosis. When the antibiotics were used in combination, no significant decrease in sensitivity of the tumor cells to either of the drugs or their combination was observed. The experiment with Staph. aureus also showed that the rate of the resistance increase to the drug combination was lower than that to the drugs used alone. Therefore, it was shown that the combined use of bruneomycin and rubomycin provided a means for preventing to a significant extent of development of the resistance in lymphadenosis tumor cells and Staph. aureus. This may be considered as an indication for clinical trials of the above combination.

Animals↗
PubMed1977

[Benign cutaneous lymphadenosis (Bäfverstedt's disease) of the nipple (author's transl)].

Benign circumscribed cutaneous lymphadenosis of the areola of the nipple (Bäfverstedt's disease) occurs in children and adults. We observed 11 cases: 3 men, 3 children and 6 women. The areola undergoes rapid swelling and becomes red. At times the nipple itself is included. Unilateral enlargment and distortion of the nipple area becomes apparent. Sometimes this is associated with a tumor-like infiltration of the retro-mammillary tissue. In Contradistinction to Pagets disease of the nipple and to a mammillary adenoma there is no eczema and no ulceration. The clinical features and the typical pruritic course establish the diagnosis. Healing is spontaneous, but protracted. The aetiology is probably of an inflammatory nature. Treatment with short courses of antibiotics and anti-inflammatory agents resulted in a faster reduction of the cutaneous signs and corroborated the clinical diagnosis. We consider surgical treatment as unnecessary because circumscript benign lymphadenosis of the nipple area has a harmless course.

Adolescent↗
PubMed1980

[Hematomorphological differential diagnosis of small cell lymphoma. What is the atypical chronic lymphadenosis?].

More importance is being attached to haematologic cell morphology, particularly in the field of small-cell non-Hodgkin lymphomas. This shifting of diagnostical validity from the structural substrate to the cellular one can clearly be illustrated by the transition of classification according to Rappoport to that according to Lennert (Kiel-classification). Here minute cytomorphological criteria acquire a new validity by their significance in the microscopic cut preparation and in the electron-microscope as well as by their correlation to cell-immunological parameters. Thus, it is possible to make a differential diagnostics of the extending small-cell lymphomas from the blood picture. It enables an ensured morphological differentiation to be made for typical B-lymphadenosis, prolymphocytic leukaemia, T-cell lymphadenosis, lymphoplasmocytoid immunocytoma, centrocytoma, and hairy cell leukaemia. The relevance of this differentiation can be further identified by a consequent immunologic cell characterization.

Cytodiagnosis↗
PubMed1978

[Coincidence of chronic lymphadenosis and lymphogranulomatosis].

A case is reported on the joint presence of chronic lymphatic leukaemia and lymphogranulomatosis in a 58 years old patient. 5 years after diagnosis and therapy of lymphadenosis a lymphogranulomatosis existing in addition to lymphadenosis was discovered by autopsy. Previously a change of symptoms had occurred. This became evident in the regression of palpable lymph node swellings as well as leukocytosis and lymphocytosis, in a change of the differential blood picture and the presence of periodic subfebrile temperatures. Problems connected with these double neoplasias are briefly outlined and discussed.

Hodgkin Disease↗
PubMed1990

Differentiation between lymphadenosis benigna cutis and primary cutaneous follicular center cell lymphomas. A comparative clinicopathologic study of 57 patients.

The authors report the clinical and histologic features of 22 cases of lymphadenosis benigna cutis (LBC) and 35 cases of primary cutaneous follicular center cell (FCC) lymphoma. The differential diagnostic accuracy of criteria generally used for differentiating between benign and malignant cutaneous lymphoid infiltrates was evaluated. The clinical and histologic findings in these two groups showed many similarities. Except for a characteristic clinical presentation of patients with a primary cutaneous FCC lymphoma on the trunk, there was no single clinical or histologic criterion that reliably differentiated between both conditions in all cases. Follow-up data showed that only a small number of patients of the malignant group developed (four of 35 cases) or died of (two of 35 cases) systemic lymphoma. The favorable prognosis of this type of cutaneous lymphoma implies that lack of systemic lymphoma after a five-year follow-up cannot be used as a diagnostic criterion in retrospective studies.

Adult↗