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Results for “Laryngeal Edema”

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At least 19 recordsLinked to original sources
PubMed1978

Management of a patient with hereditary angioneurotic edema.

Patients with a history of hereditary angioneurotic edema can adequate and safely have nonelective surgical procedures performed with proper preoperative and postoperative management. Deficient amounts of C1 esterase inhibitor can be replaced with fresh frozen plasma; capillary permeability and spreading edema can be prevented with antifibrinolytic agents such as Amicar. Once edema has occurred peripherally and no laryngeal symptoms are present, conservative treatment is advisable. When epiglottic and laryngeal edema occurs, intubation or tracheostomy is preferred for maintenance of airway until the edema subsides. During oral surgical procedures, minimal surgical trauma must be achieved. Edema that involves the airway presents the greatest danger to patients. These attacks are usually associated with dental or some sort of oral or pharyngeal manipulation.

Angioedema↗
PubMed1978

Chemodectoma of the larynx. A clinico-pathological study.

The present case report is concerned with a clinico-pathological study, including ultrastructural investigation, of a rare and uncommon laryngeal tumour, a chemodectoma, in a 62 year old patient. There have been 23 cases of laryngeal chemodectomas reported in the literature, and only three of them, including our own report, were investigated by electron microscopy. The tumours arise from the superior and inferior larynegeal nonchromaffin paraganglia or possibly from Kultschitzky-cells of the normal bronchial mucosa. Ultrastructurally they have all the characteristics of apudomas whose parent cells (APUD-cells), usually show endocrine function and probably have their origin in the neural crest. The tumours show an aggressive type of behaviour, despite usually benign histological features when compared to chemodectomas at other sites in the head and neck region. Surgery is thus the therapy of choice.

Humans↗
PubMed1976

[Endoscopic-histological differential diagnosis of rare benign endolaryngeal proliferations (author's transl)].

In the period from 1961 to August, 1975, 2,222 microlaryngoscopic examinations were carried out at the ENT Department of the University. A correlation was seen between the increase in the number of examination in the last few years and the increase in the number of malignant tumours of the larynx, while malignant growths in the hypopharynx were found to be only slightly increased. An anlysis of 1,027 microlaryngoscopies carried out under anaesthesia over the last 2 2/3 years showed almost 50% cancers and precancers. In 5% of the case at most more rare laryngeal findings were also seen. Of these, the granular cell tumour, plasmocytoma, oncocytic cystadenoma and amyloid-tumour of the larynx, but also tuberculous laryngitis, are represented. The modern endoscopic examinations and the fundamental bioptic histomorphological examination of proliferations allow an exact differentiation of these changes in the tissues of the endolarynx. In this connection, a valuable technical aid is the v. Stuckard low-power magnifying laryngoscope, that has been in use for the past six months.

Adolescent↗
PubMed1977

Results of integrated management of supraglottic carcinoma.

Between January 1957 and June 1974, 173 patients with carcinoma of the supraglottic larynx were treated by an integrated approach at the University of California in San Francisco. The policy was to use radiotherapy or surgery alone for Stage I and II disease, radiotherapy combined with either supraglottic laryngectomy or total laryngectomy for resectable Stage III and IV disease, and radiotherapy alone for advanced unresectable disease. Control of the disease in the primary site was achieved in 92% of T1a, 88% of T1b, 80% of T2, 79% of T3 and 56% of T4 lesions. Of the 36 patients with late Stage I and resectable Stages III and IV disease treated by combined preoperative radiotherapy and supraglottic or total laryngectomy, the primary lesion was controlled in 33 (92%). Recurrent disease in the primary site after radiotherapy alone, when detected early, was usually controlled by subsequent surgery, whereas recurrent disease after surgery was not controlled by radiotherapy. Preservation of a functioning vocal apparatus was achieved in 44% of the patients whose primary lesion was controlled. Control of cervical lymph node metastasis was achieved in 71% of N1, 38% of N2, and 25% of N3 disease. No disease recurred in the radically dissected neck which received preoperative radiotherapy. Radiotherapy also reduced the incidence of subsequent neck disease in patients without cervical lymph node metastasis initially from 23% to 14%.

Adult↗
PubMed1976

[About some changes of the vocal cord mucosa and of Reinke's Subepithelial space (author's transl)].

The mechanical irritation alone or in combination with an inflammatory component and fragility of blood vessels plays the decisive role in the development of some vocal cord morphological changes. The duration of the mechanical irritation modifies the clinical picture. The plase of the strongest physiological mechanical irritation is the place of localization of the vocal cord morphological changes. The histological picture of different pathomorphological vocal cord changes is almost identical, this being the consequence of the specific structure of Reinke's subepithelial space. The treatment of all these morphological entities is surgical by means of microlaryngoscopy, except in cases of recent nodules which respond to conservative phoniatric therapy in the majority of cases.

Epithelial Cells↗
PubMed1978

Larynx cancer: a therapeutic policy at the Madras Cancer Institute.

We studied 145 cases of larynx cancer in relation to their etiology, methods of treatment, and results. It was found that better results were obtained with a combination of radiotherapy and surgery. Any postradiational edema of the larynx should subside within 3 months. If this edema persists or progresses, it always means residual disease in the submucosal plane. We have now improved our results by using intravenous Bleomycin concurrently.

Adult↗
PubMed1975

Angioneurotic edema. A review of modern concepts.

We review the subject of angioneurotic edema with special emphasis on the more clearly defined entity of hereditary angioneurotic edema. The clinical presentations of the various forms of angioneurotic edema are discussed. Attention is directed toward the attempts that have been made to define this group of diseases in terms of their underlying biochemical mechanisms. A simplified schema of the serum complement system is presented. We conclude that only after we understand such biochemical interactions will we able to effect a more definitive form of therapy for the angioneurotic edemas.

Acute Disease↗
PubMed1976

[Laryngo-tracheal injuries in hangings (apropos of 359 cases)].

Hanging is a relatively frequent method of suicide, and strangulation (accidental or volontary) may cause direct laryngeal or tracheal trauma and various lesions which may express themselves clinically either: -early, was severe from the start, e.g. fracture of the larynx, with major ventilatory distress, -or delayed, simple trauma without fracture, becoming manifest only after a few hours with severe dyspnea. In any case, early and late complications of these traumas require, even when they are apparently benign, admission to hospital on a specialised unit able to carry out rapidly respiratory intensive care.

Edema↗
PubMed1976

[Laser surgery of the vocal cord. An experimental study (author's transl)].

In animals the endolaryngeal application of laser rays of the Nd: YAG Laser MediLas (lambda = 1.06 mum) was tested under microsurgical conditions, the early and late alterations of the vocal cords caused by a dosage of 17 watt/mm2 fractioned over 7 sec were endoscopically observed and studied by light- and electronmicroscopy. A circumscribed vocal cord edema induced by laser entails no functional impairment whatsoever. Histologically the laser lesions can be interpreted as epithelial defect with a reactive inflammation of the adjacent connective tissue. A fundamental loss in substance cannot be realized. The superficial defect healed within 18 days; after 7 weeks the zone of regeneration and the undamaged part of the vocal cord could no longer be differentiated neither by light- nor by electronmicroscopy. Laser surgery has the special merit of permitting a touchless and bloodless operation. These experiences with the Nd: YAG Laser MediLas encourage us to use this procedure in clinical tests for the therapy of benignant squamous epithelium hyperplasia of vocal cords.

Animals↗
PubMed1976

[Subepithelial changes in simple leukoplakic hyperplasia of the laryngeal mucosa (author's transl)].

Subepithelial changes in hyperplasia of the laryngeal mucosa consist in edema and cellular inflammatory reaction. 150 cases of epithelial hyperplasia without atypia have been investigated histologically in regard to these subepithelial changes. The cases were subdivided into 3 categories, according to the degree of hyperplasia. The degree of inflammatory reaction in the subepithelial compartment also was classfied into 3 groups. A, B and C. There was evidence of a positive correlation between the increase in the epithelial hyperplasia and the increase of a positive correlation between the increase in the inflammatory process in the subepithelial layer. It could not be decided, which one of these two pathological changes was primary and which secondary. The therapy, however, should aim at both, epithelial proliferation, as well as, subepithelial inflammation.

Epithelial Cells↗