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Laser therapy proved to be effective in the treatment of patients with trophic ulcers, deforming arthrosis of the I and II degree, and particularly, in early stages of inflammatory processes (infiltrative stage) and in some surgical diseases, as well. So, there are all the grounds for further and more broad and profound experimental and clinical study of laser therapy in various diseases, surgical ones, in particular.
A new method has been developed allowing the introduction of the argon laser beam into the water-filled bladder using normal operation cystoscopes. The energy is applicated to the bladder by means of a light conductor which is placed into the bladder through the working channel of an operation cystoscope. Treating large tumors of the bladder we laser the resection bed after electroresection (TUR). The sole use of laser therapy on large tumors of the bladder is not to be recommended because of the uncertainty of their total destruction. On the other hand, the sole laser coagulation of small relapses of tumor up to the size of raspberries restricted to the mucous membrane seems to be more effective than electroresection. The advantage of laser treatment is the absence of electric power flow through the tissue which avoids muscle convulsions of the bladder and electric power leakage. Besides of this, laser therapy being painless allows treatment without anesthesia. So far 68 patients with tumors of the bladder have been treated by transurethral laser therapy combined with electroresection (TUR). The aim of transurethral laser therapy is the reduction of recidivity of bladder tumors.
BACKGROUND: Scarring caused by trauma, burns, surgery, and other dermal fibrotic conditions can lead to functional limitation and cosmetic distress. The comparative effectiveness of fractional laser therapy and microneedling for non-acne scars remains uncertain. METHODS: We conducted a systematic review and meta-analysis of randomized controlled trials comparing fractional laser therapy with microneedling for non-acne scars and scar-like dermal fibrotic lesions. Following a PROSPERO-registered protocol and PRISMA guidelines, we searched PubMed, EMBASE, Web of Science, Cochrane Library, and CNKI from inception to May 2026 without language restrictions. Parallel-group and split-body randomized trials were eligible. Random-effects models were used to calculate standardized mean differences (SMDs) for continuous outcomes and odds ratios (ORs) for dichotomous outcomes. RESULTS: Nine randomized controlled trials were included. Fractional laser therapy showed a statistically significant advantage over microneedling in scar scores (SMD = -0.99, 95% CI [-1.83, -0.15], P = 0.02) and collagen fiber regeneration (SMD = -2.14, 95% CI [-3.57, -0.72], P = 0.03). No statistically significant differences were found between the two interventions for elastic fiber improvement, epidermal thickness, or adverse events. Subgroup analyses did not show clear or consistent significant differences according to laser type, including comparisons between traditional and non-traditional fractional lasers and between CO₂ and non-CO₂ fractional laser systems. Substantial heterogeneity was observed across several outcomes, indicating considerable between-study variability. CONCLUSION: Based on currently available randomized evidence, fractional laser therapy may provide superior improvement in overall scar severity and collagen fiber regeneration compared with microneedling for non-acne scars and scar-like dermal fibrotic lesions. However, no clear differences were observed for elastic fiber improvement, epidermal thickness, or adverse-event incidence. Given the substantial heterogeneity, limited sample sizes, and possible reporting bias, these findings should be interpreted cautiously. Further large, standardized trials with longer follow-up are needed.
Surgical resection remains the therapy of choice for the treatment of potentially curable gastrointestinal tract (GI) malignancies. Many of these tumors are incurable at the time of diagnosis and therapy should be directed towards palliation with the intent of minimizing pain, bleeding, obstruction, and potential morbidity. Endoscopic laser therapy is uniquely applicable for the palliation of GI tumors and in selective instances may be appropriate for the treatment of early lesions. Eighty-six patients with GI malignancy have been treated at our institution since 1985. Thirty-one patients had advanced upper GI lesions (esophagus: 26, gastric: 3, duodenal: 1, and pancreatic: 1) and 55 patients had lower GI tumors (colon: 37 and rectal: 18). Pre-resectional recanalization for obstructing colorectal carcinomas obviating initial operative diversion was performed in 31 (56%) of 55 patients. Twenty-four patients had palliative laser therapy (obstruction: 17 and hemorrhage: 7) with resolution of their symptoms. There was 1 laser related perforation in the pre-resectional group and the overall complication rate was 1.2%. Endoscopic Nd:YAG and currently photodynamic laser therapy for GI tumors has proven to be an effective mode of therapy for advanced GI neoplasms with minimal morbidity. The utility of photodynamic therapy for the treatment of early stage esophageal and gastric cancers remains controversial.
PURPOSE: High-intensity laser therapy (HILT) and ultrasound (US) are widely used for knee osteoarthritis (KOA), but comparative efficacy data remain scarce. This study compared HILT and US as exercise adjuncts in patients with KOA. METHODS: In this single-center, assessor-blinded RCT, 66 adults with KOA were randomized 1:1 to HILT or US twice weekly for 6 weeks as exercise adjuncts. The primary outcome was WOMAC total score change from baseline to 12 weeks post-treatment (minimum important change [MIC] = 10 points, applied as an approximation). Secondary outcomes included VAS, OKS, KOOS, and EQ-5D-5L. RESULTS: In ITT analysis (N = 66), the HILT group achieved a mean WOMAC reduction of 40.0 vs 8.2 points (adjusted between-group difference: -27.7 points, 95% CI: - 39.0 to - 16.5; p < 0.001, partial η2 = 0.277). At 12 weeks post-treatment, greater improvements across all secondary outcomes were observed in exploratory analyses (p ≤ 0.012). Furthermore, HILT maintained therapeutic effects up to 12 weeks post-treatment, whereas the US group experienced a gradual loss of post-treatment gains. CONCLUSION: HILT combined with exercise produced greater short-term improvements in WOMAC total score than US in patients with KOA, with exploratory findings suggesting consistent benefits in pain, function, and quality of life, and with benefits maintained up to 12 weeks after the last treatment session.
The investigation of effects of the red light of the helium-neon laser on hemopoiesis of experimental animals has provided data on the activation of erythropoiesis and the presence of the leucocyte redistribution reaction in the peripheral blood. No pathological changes in the morphological composition of the peripheral blood were detected in patients with a deforming arthrosis and patients with gastric ulcer in the process of laser therapy. Favourable changes were noted.
Similar complications have been reported with both xenon arc and argon laser photocoagulation. Emphasis has been placed on complications in the posterior segment. However, with the argon laser, anterior segment complications such as iritis, focal iris atrophy, inequality of pupil size, posterior synechiae, anterior subcapsular and cortical lens opacities and corneal leukomata may occur. The majority of these complications may be prevented by adequate dilatation of the pupil, patient cooperation, and selective use of retrobulbar anesthesia.
Vascularization was induced in rabbit corneas by the application of silver nitrate. Argon laser photocoagulation was applied to the entire length of these corneal vessels with relatively long pulses of energy. Untreated areas of vascularization were used as controls. There was a decrease in the corneal vascularization in the treated areas that exceeded any natural tendency toward remission. The results suggest the efficacy of inducing a remission of corneal vascularization with argon laser photocoagulation.
The chairman of this roundtable discussion summarizes the topics of the session. As an introduction the advantages and disadvantages of Laser coagulation versus Xenon coagulation are discussed. Several diseases are analysed mainly with respect to indications or contraindications for Laser coagulation: prophylactic treatment of retinal detachment, dry senile maculopathies, exsudative maculopathies (central serous retinopathy, retinal pigment epithelial detachment, Fuchs myopic maculopathy, exudative senile maculopathy, Junius-Kuhnt pseudotumor), diabetic non proliferative and proflierative retinopathy.
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15 patients with papillary bladder tumors were radiated with a Neodym-YAG laser beam since summer 1976. The seize of the tumors ranged from 5 to 10 mm in diameter. Neither complications nor tumor recurrency in the former tumor area could be observed. A final statement about the value of laser radiation in malignant tumors is not yet possible because of the small number of patients and the short control period. However, our preliminary experiences might be a beginning of a successful improvement of bladder tumor therapy by use of endoscopic laser radiation.
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Explore the source record for details and available documents.