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At least 19 recordsLinked to original sources
PubMed1984

The leukemoid reaction in shigellosis.

Leukemoid reactions occurred in 136 patients (3.8%) hospitalized with shigellosis in Bangladesh. Sixty-eight percent of the patients with leukemoid reactions were children less than 4 years old. When compared with patients without leukemoid reactions, the leukemoid reactions were significantly associated with children aged less than 10 years. The most common serotype of Shigella in the patients with leukemoid reactions was Shigella dysenteriae 1, isolated from 96 patients (71%), whereas the most common species in patients without leukemoid reactions was Shigella flexneri, isolated from 2,119 patients (62%). The case fatality rate in patients with leukemoid reactions was 21% compared with 7.4% in patients without leukemoid reactions. These findings indicated that in patients with shigellosis, the leukemoid reaction was significantly associated with young children, isolation of S dysenteriae 1, and increased case fatality rate.

Bangladesh↗
PubMed1990

Monocytic leukemoid reaction, glucocorticoid therapy, and myelodysplastic syndrome.

A leukemoid reaction is a complex and poorly understood response by the bone marrow to a variety of stresses; although any peripheral blood cell line may be involved, it is rarely a purely monocytic event. A case is reported of a true monocytic leukemoid reaction in a patient with myelodysplastic syndrome related to the effect of corticosteroids on the underlying marrow disorder.

Aged↗
PubMed1989

Inflammatory fibrous histiocytoma presenting leukemoid reaction.

A case of inflammatory fibrous histiocytoma presenting leukemoid reaction is reported. A tumor had developed at the right scapular region 10 years ago and recurred twice with fever and leukocytosis, and finally with leukemoid reaction. Besides the histopathological features typical of malignant fibrous histiocytoma, this tumor showed prominent and diffuse infiltration of neutrophilic leukocytes. Hematologic examination of the bone marrow aspirates disclosed myeloid hyperplasia. Bacteriological examination revealed no pathogenic microorganisms in the tumor tissue. Chemotactic activity of the neutrophilic leukocytes was demonstrated in the extract obtained from the tumor, and subcutaneous injection of the extract into rats induced myeloid hyperplasia in the bone marrow and neutrophil infiltration in the liver and spleen of the animals. These results suggest the possibility of the case as a colony-stimulating factor-producing tumor.

Aged↗
PubMed1980

Transient leukemoid reaction and trisomy 21 mosaicism in a phenotypically normal newborn.

Transient leukemoid reactions that resemble acute leukemia have been well described for infants with trisomy 21 (Down syndrome). We report a phenotypically normal 3-day-old boy with hepatosplenomegaly, leukocytosis, and circulating myeloblasts. On chromosome analysis, trisomy 21 was found in all blood and bone marrow cells. However, only 4% of cultured skin fibroblasts were trisomic and the other 96% were normal, thus indicating mosaicism. Without treatment, the leukocyte count gradually returned to normal and the organomegaly diminished. Subsequently, chromosome analysis of blood and bone marrow disclosed a predominance of cells with a normal karyotype. These findings suggest that mosaicism could be responsible for the transient leukemoid reactions in some newborns--i.e., the trisomic cells may temporarily gain a proliferative advantage over the normal cells, perhaps by inhibiting their growth. Serial cytogenetic studies, as well as chromosome analysis of more than one tissue, may help to distinguish transient leukemoid reactions from acute leukemia in infants.

Bone Marrow Cells↗
PubMed1986

Leukemoid reaction in a patient with bladder and prostatic cancer.

Leukemoid reactions often are seen in patients with underlying malignancies but they have been reported infrequently in patients with urological malignancies. We report reactive leukocytosis and thrombocytosis in a patient with bladder and prostatic carcinoma. Both hematological abnormalities resolved with definitive surgical therapy. We also review other reported cases of leukemoid reactions in patients with urological malignancies.

Adenocarcinoma↗
PubMed1977

Kinetic studies of a tumor-induced leukemoid reaction in mice.

A transplantable murine breast carcinoma in mice was associated with marked leukemoid reaction. Within 1 week of subcutaneous implantation of tumor the leukocyte count began to increase and reached average levels of 165,000 leukocytes per cubic millimeter within 18 days. This represented an increase in mature neutrophils primarily, although other blood leukocytes were modestly increased as well. The total number of neutrophils per humerus was increased but no increase was detected in the number of myloblasts, promyelocytes, or myelocytes. The tritiated thymidine-labeling index of the latter three cells was not significantly changed during tumor growth. The number of progenitor cells forming granulocytic and mononuclear cells in vitro was decreased in the marrow during tumor growth. Colony-stimulating activity in plasma was slightly increased during the early phase of tumor growth and decreased during later phases. Emergence time of blood neutrophils was normal, as measured by labeling with tritiated thymidine, but decline in labeled cells was abnormally slow in tumor-bearing mice. There was a shift of erythropoiesis to the spleen, but total erythropoiesis appeared to be normal in most mice. Surgical excision of the tumor resulted in prompt reversal of the leukemoid reaction. In the aggregate these results are consistent with a hypothesis that the leukemoid reaction was the result of increased blood transit time of neutrophils primarily, rather than increased neutrophil production.

Animals↗
PubMed1987

[Leukocytosis, the leftward shift of the white blood picture and leukemoid reactions in the internal medicine clinic].

The white blood count of 6549 patients with various internal diseases of respiratory, cardiovascular, gastrointestinal, excretory and endocrine systems was studied as well as in neoplasms, collagenosis, etc. with the exception of malignant hemopathies. Leukocytosis was established in 21.8% of them. In almost half of the cases, leukocytosis is low, in 44.6% it ranges from 12-20 X 10(9)/l and in 10.2%--it is high--from 20 to 40 X 10(9)/l. Immature cells in the peripheral blood were established corresponding to stab neutrophils over 0.06-0.10, metamyelocytes, myelocytes reaching myeloblasts in the cases with leukemoid reactions. The leukemoid reactions have, with no exceptions, been of myeloid type and developed in various diseases.

Adolescent↗
PubMed1988

Leukemoid reaction in erythema nodosum leprosum in a leprosy patient.

A case of lepromatous leprosy with erythema nodosum leprosum (ENL) presenting as a myeloid leukemoid reaction is reported. Very high leucocyte count with immaturity of the cells in myeloid series was present in peripheral blood. High leucocyte alkaline phosphatase score, absence of hepatosplenomegaly and transient nature of leukemoid reaction differentiated it from chronic myeloid leukemia and acute myeloblastic leukemia. The possible mechanisms of leukemoid reaction in ENL are discussed.

Adult↗
PubMed1983

Comparison of circulating colony-forming cells in chronic granulocytic leukemia and leukemoid reaction.

In vitro culture studies of peripheral blood leukocytes using semi-solid media from 8 patients with chronic granulocytic leukemia (CGL) and 5 patients with granulocytic leukemoid reaction were performed. A markedly increased number of circulating colony-forming units were present in patients with CGL (mean 343 +/- 47) as opposed to those having granulocytic leukemoid reaction (mean 7.0 +/- 4). The colony size was larger in CGL than in granulocytic leukemoid reaction or in normal peripheral blood.

Cells, Cultured↗
PubMed1983

[Neonatal leukemoid reaction caused by prenatal corticoid administration?].

A leukemoid reaction in the neonatal phase of a preterm infant is described. After a maximum of 112,000/microliter at the forth day leukocyte concentration normalized during the end of the second week of life. Intensive investigations could reveal none of the known causes of leukocytosis. The connection with maternal corticoid administration to prevent respiratory distress syndrome is discussed.

Adult↗
PubMed1990

[Leukemoid reaction caused by hypernephroma primary diagnosed as chronic granulocytic leukemia].

A case of leukemoid reaction associated with renal carcinoma is presented. On account of the high leukocyte count and a palpable abdominal mass in the upper left quadrant, interpreted as an enlarged spleen, the primary tentative diagnosis was chronic granulocytic leukemia. Abdominal ultrasonographic scan revealed an enlarged left kidney and subsequent nephrectomy revealed a large hypernephroma. Leukemoid reactions associated with malignant disease are described in general with emphasis on the differential diagnosis.

Adult↗
PubMed1976

An autopsy case of liposarcoma with granulocytic leukemoid reaction.

A 57-year-old female with a large retroperitoneal tumor was atutopsied. She showed through the entire course of illness marked leukocytosis with the appearance of immature marrow cells, and this finding was hematologically interpreted as granulocytic leukemoid reaction. An intermittent pyrexia was also seen without infective etiology. The histologic diagnosis of the tumor was liposarcoma of the pleomorphic type. The tumor showed extensive necrosis, but no metastatic invasion was found. So-called leukemoid reaction appears sometimes together with malignant neoplasms. The majority of these tumors show widespread bone marrow metastases, and without bone marrow invasion they only rarely induce this reaction. Besides it is not common for leukemoid reaction to be evoked by the development of malignant mesenchymal tumors except for malignant lymphomas. The pathophysiologic process of the present of the present case is thought to be a rare occurrence.

Autopsy↗
PubMed1978

Host genetic factors influencing the occurrence of leukemoid reaction in BALB/cMk mice bearing transplanted tumors.

Host genetic factors influencing the occurrence of leukemoid reaction in BALB/cMk strain mice bearing transplanted tumors were studied. A Mendelian hybridization experiment was performed with BALB/cMk and C57BL/6 strains, and their strain hybrids; the first filial (F1) generation hybrids; the second filial (F2) generation hybrids; and the backcrosses to the two parental strains. The results of these studies suggested a genetic regulation of leukemoid reaction occurrence in BALB/cMk mice bearing transplanted tumors. Genes permissive to the occurrence of the reaction seemed to be dominant to their nonpermissive alleles.

Animals↗
PubMed1982

Neonatal leukemoid reaction. An isolated manifestation of mosaic trisomy 21.

A phenotypically normal neonate with an unexplained leukemoid reaction had a 46,XX/47,XX, +21 karyotype limited to the hemopoietic system. Although a self-limited myeloproliferative syndrome occurs in Down's syndrome, this case confirms that an identical disorder may develop in patients with mosaic trisomy 21 and no phenotypic stigmas of Down's syndrome. Chromosome analysis is a necessary adjunct to the examination of any neonate with an unexplained leukemoid reaction. The presence of trisomy 21 should lead to conservative management, unless there is life-threatening progression of the disease.

Down Syndrome↗
PubMed1986

Leukemoid reaction associated with severe diabetic ketoacidosis.

A 30-year-old man had severe diabetic ketoacidosis and a leukemoid reaction, which promptly resolved after therapy with intravenous fluids and insulin. There was no evidence of an underlying malignancy or infection. Although a mild leukocytosis may accompany DKA, a leukemoid reaction has not been previously reported to occur with uncomplicated diabetic ketoacidosis.

Acute Disease↗
PubMed1990

Transitory T-lymphoblastic leukemoid reaction in a neonate with Down syndrome.

A transient leukemoid reaction in a neonate with Down syndrome is reported. The blastic proliferation was identified as T lymphoblastic in an early stage of maturation (prethymocytes) using morphological, cytochemical, and immunological methods. A spontaneous complete remission occurred in 8 weeks. No additional cytogenetic alterations were found, except for those concerning chromosome 21. Other cases reported in the literature reveal that cytogenetic studies may be useful to distinguish these transient leukemic reactions from true leukemias in newborns with Down syndrome. The in vitro growth pattern of peripheral blood and bone marrow may also be useful for this purpose.

Blood Cell Count↗
PubMed1992

Myeloblastic leukemoid reaction in paroxysmal nocturnal hemoglobinuria associated with myelodysplasia.

Paroxysmal nocturnal hemoglobinuria (PNH) has been observed to evolve into myelofibrosis and acute myeloid leukemia. Myeloblastic leukemoid reaction has not been described in PNH. We described a patient with PNH with myelodysplasia and septicemia. The marrow aspirates showed a picture of myeloblastosis which subsided when sepsis was controlled. The myeloblastic leukemoid reaction in our patient related to overwhelming sepsis, splenectomy and overt hemolysis.

Bone Marrow↗