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At least 19 recordsLinked to original sources

PubMed2006

The relationship between libido and testosterone levels in aging men.

CONTEXT: Although it is known that serum testosterone (T) concentrations are related to libido, the strength of that relationship in community-dwelling men has not yet been determined. OBJECTIVE: Our objective was to assess the strength and significance of the association between aging men's self-reports of libido and serum T concentrations. DESIGN: Our study was a community-based evaluation of men's health and aging, including three data collection waves: baseline (T1, 1987-1989) and follow-ups (T2, 1995-1997; T3, 2002-2004). Libido was measured on a 14-point scale assessing self-reported frequency of desire and thoughts/fantasies; low libido was defined as a score of less than 7 of 14. SETTING: We conducted an epidemiological study in greater Boston, Massachusetts. PARTICIPANTS: There were 1632 men aged 40-70 yr at baseline, with follow-up on 922 (56%) at 9 yr (T2) and 623 (38%) at 15 yr (T3). MAIN OUTCOME MEASURES: We assessed total and calculated bioavailable T . RESULTS: Three hundred eighteen (19%) subjects reported low libido at baseline. Libido and T displayed a significant association. However, the difference in mean T levels between those subjects with low libido and those without was small; analyses indicated a 3.4 ng/dl (0.12 nmol/liter) increase in total T per unit increase in libido. Subjects reporting low libido exhibited an increased but modest probability of exhibiting low T. Dividing T concentrations by the number of androgen receptor gene cytosine, adenine, guanine repeats did not enhance associations. CONCLUSIONS: Libido and T concentrations are strongly related at the population level. However, the value of individual patient reports of reduced libido as indicators of low T levels is open to question.

Adenine↗

PubMed1986

Effect of controlled exercise on libido in 2-yr-old stallions.

Eight sexually inexperienced, 2-yr-old Morgan stallions were used in a consecutive two-phase design with two groups of four stallions each. Each phase lasted 16 wk, with semen collections every 14 d. Libido scores were assigned to stallions during each semen collection. Scores ranged from zero to four, with zero indicating minimum and four representing maximum libido. In Phase 1, four stallions received daily forced exercise for 16 wk, and the remaining four stallions were confined to box stalls. In Phase 2, the previously exercised stallions were confined to box stalls, and the non-exercised stallions of Phase 1 received daily forced exercise. No week X treatment effect (P greater than .05) was found in Phase 1. Exercised stallions, however, tended to have lower libido values than non-exercised stallions from wk 10 through wk 16. A week X treatment effect (P less than .01) was found in Phase 2. Libido scores were lower (P less than .05) over time among exercised stallions, whereas scores of non-exercised stallions tended to remain stable or rise slightly over time. Mean libido scores for exercised and non-exercised stallions were different (P less than .05) at the end of Phase 1 (2.06 +/- .37 and 3.5 +/- .37, respectively). By wk 26, mean libido scores were similar (exercised: 2.62 +/- .34; non-exercised: 2.52 +/- .34). However, by wk 32, libido values for exercised stallions were lower (P less than .05) than non-exercised stallions (1.87 +/- .34 and 2.81 +/- .34, respectively). In general, mean libido scores of the non-exercised group were higher than exercised stallions after 12 wk of forced daily exercise.

Animals↗

PubMed1976

[Disorders of libido from the gynecological view point].

Sexual dysfunctions are differentiated according to the following symptoms: libido dysfunction, orgasmic dysfunction, vaginism, algopareunia and polysymptomatic dysfunction. In the out-patient service for sexual and other psychosomatic disorders of the University of Heidelberg's Women's Hospital 90 women with libido dysfunction were treated with conflict-centered psychotherapy after exclusion of organic diseases which could explain the reduction of libido and after exclusion of a depression where the loss of libido is a regular symptom. The success-rate was 63%. It was attempted to reinforce the ego of the patient which enables him to experience his surroundings with less conflicts. Neurotic anxieties and symptoms are decreased and loos their importance so that the patient is able to handle his sexual disturbance. Among the psychosocial factors, i.e. focal causes, responsible for the libido dysfunction we found: In 48% of the cases the relationship between parents and children had been disturbed, which caused difficulties in the identification process (lack of father or mother, cool mother, divorce, borken home). Problems with the partners were found in 42%. 2/3 of these women had not grown up in intact families, which seems to predestinate difficulties in communication later on. Psychodynamically the loss of libido means sexual resistance which can lead to aversion or disgust. When there is no excitement the vasocongestion and lubrication do not take place: cohabitation pain (algopareunia) results. On the other hand the reduction of libido can also be a result of chronic algopareunia, i.e. secondary. Psychogenic bleedings ("aversion-bleeding") during or after intercourse occasionally occur in combination with algopareunia and lack of libido.

Dyspareunia↗

PubMed2002

Prevention of chronic alcohol and nicotine-induced azospermia, sterility and decreased libido, by a novel tri-substituted benzoflavone moiety from Passiflora incarnata Linneaus in healthy male rats.

Excessive long term consumption of alcohol and nicotine have serious detrimental effects upon the libido, fertility, and sperm count in male species. The present work describes the beneficial effects of a novel tri-substituted benzoflavone moiety (BZF) isolated from Passiflora incarnata Linneaus, the phyto-chemical isolation, spectroscopic elucidation, and multifarious biological activities of which have recently been reported by the authors. The BZF moiety has been reported to increase libido, sperm count, and sexual fertility in 2 years old male rats at 10 mg/kg, po dose, in the one of our previous studies. Presently, the BZF moiety has been evaluated against chronic ethanol- and nicotine-induced decrease in libido, sexual fertility and mating efficiency in healthy male rats. The male rats were given ethanol (3 g/kg, po) A, nicotine (2 mg/kg, sc) N, alcohol-nicotine combinations (AN) alone, and also with 10 mg/kg po dose of BZF (concurrent administrations). These treatments were given for 30 days. At the end of treatments, it was observed that rat groups A, N, and AN had no libido (evaluated by mounting behaviour), declined sperm count, and consequently no mating efficiency or fertility (upon pairing with pro-estrus female rats). However, the rats which were given 10 mg/kg BZF along-with nicotine (NP group), alcohol (AP group), and alcohol-nicotine combination (ANP) exhibited significant libido-oriented mounting behaviour, increased sperm count (significantly comparable to the control group), and increased fertilization potential. The rats having decreased sperm count, libido and fertilization potential due to chronic administration of alcohol, nicotine and alcohol-nicotine combinations, i.e., rats of A, N, and AN groups were again subdivided and were given 10 mg/kg BZF for 7 days. This treatment confirmed that BZF speeds up the restoration of sexuality in rats upon cessation of the administration of substances like alcohol, nicotine and alcohol-nicotine combinations, which have severe detrimental effects upon male sexuality, fertility and vigour. BZF, the strongest inhibitor of aromatase enzyme, when administered concurrently with substances like alcohol and nicotine restores sexual virility, libido and vigour in male rats by maintaining the blood-testosterone levels to be high.

Alcoholism↗

PubMedDate not supplied

Predictors of decreased libido in women during the late reproductive years.

OBJECTIVE: To identify risk factors for decreased libido among women in the late reproductive years. DESIGN: Prospective cohort. Women aged 35 to 47 years identified through random digit dialing were prospectively followed for 4 years with serial hormone assays and standardized questionnaires. Mean hormone values, hormone trends over 4 years, and fluctuation in hormone levels were compared among women with and without a decrease in libido at the last assessment period. Total testosterone, dihydroepiandrosterone sulfate, estradiol, follicle-stimulating hormone, luteinizing hormone, body mass index, psychosocial, and socioeconomic variables were evaluated using multivariable logistic regression. RESULTS: Of 326 women, 87 (27%) reported a decreased libido, whereas 239 (73%) did not. Participant-specific means for all hormone levels over the study period were similar among both groups. However, total testosterone fluctuation over the study was significantly different between groups. Women whose testosterone levels fluctuated from 3.8 to 21.5 ng/dL around a mean value of 9 ng/dL were four times more likely to report decreased libido compared with women with little fluctuation in testosterone [odds ratio (OR) 4.0; 95% CI, 1.6-10.0]. Depression (OR 3.4; 95%CI, 1.9-6.1), vaginal dryness (OR 3.5; 95%CI, 1.8-6.6), and children living at home (OR 1.4; 95%CI, 1.1-1.7) were also independently associated with decreased libido. CONCLUSIONS: Decreased libido in the late reproductive years is associated with a pronounced fluctuation in total testosterone over time. Other independent risk factors for decreased libido include vaginal dryness, depression, and living with children. Sexual dysfunction is a complex disorder, related to physiological and psychosocial factors, requiring further investigation.

Adult↗

PubMed2004

Oral contraceptives and libido in women.

Oral contraceptives (OCs) provide safe, effective, and reversible contraception and are widely used by women for fertility control. Little is known about the effects of OCs on sexual functioning. This paper critically examines the published literature addressing the impact of OCs on sexual desire or libido. We reviewed 30 original research studies. In the retrospective, uncontrolled studies (n = 17), it was found that most women reported an increase in libido during OC use. In the uncontrolled, prospective studies (n = 4), it was found that most women reported little change in libido during OC use. In the prospective and cross-sectional controlled studies (n = 4), women using OCs reported both increased and decreased libido compared to non-OC users. The findings from randomized, placebo-controlled studies (n = 5) were mixed: In the most recent and well-conducted trial, a decrease in libido in OC users compared to placebo users was found. Overall, women experience positive effects, negative effects, as well as no effect on libido during OC use. Better-designed studies are needed to establish the independent, causal effects of OCs on libido.

Affect↗

PubMed1998

Serum testosterone concentration, efficiency of estrus detection and libido expression in androgenized beef cows.

Twenty multiparous, cyclic, nonlactating beef cows were blocked by dominance rank and randomly and equally allotted to 1 of 4 treatment groups: an untreated control group, a synovex-treated group which received 8 Synovex-H implants with no additional hormones, a testosterone-treated group which received 500 mg, i.m. and 1500 mg, s.c. testosterone enanthate on Day 1 with additional 1000 mg, s.c. doses of testosterone enanthate every 14 d, and a synovex + testosterone-treated group which received 8 Synovex-H implants with 500 mg, i.m. and 1500 mg, s.c. testosterone enanthate on Day 1 only. Blood samples were collected via jugular venipuncture once a week beginning 3 wk prior to start of treatment. In addition, samples were collected just prior to treatment; once a day for 1 wk after initiation of treatment; and then twice a week until 225 d after treatment. Efficiency of estrus detection was assessed 22 d prior to start of treatment and every 14 d thereafter for 98 d, using estrus detection trials with synchronized females or modified libido tests. Scores for estrus detection trials included total mounts in 1 h and the percentage of estrous cows detected. Libido was scored on a scale of 0 through 6. All testosterone treatments raised plasma testosterone concentrations above control and pretreatment levels (testosterone and synovex + testosterone > synovex > control; all P < 0.05). Synovex-, testosterone- and synovex + testosterone-treated females performed more mounts in 1 h than the controls (18, 9, 6 and 1, respectively; all P < 0.05). All testosterone-treated cows mounted a higher number of estrous females than the controls (P < 0.05). Only synovex + testosterone- and testosterone-treated cows received libido scores above pretreatment and control values. However, libido of testosterone-treated cows decreased over time, while that of synovex + testosterone-treated females remained high until Day 98. Libido scores correlated positively with the number of mounts in 1 h and the percentage of estrous females detected (0.70 and 0.44, respectively), and the correlation coefficient for these two factors was 0.63. In conclusion, the synovex + testosterone treatment was most effective for producing estrus detector females and libido testing was useful for evaluating sexual activity in androgenized females.

Animals↗

PubMedDate not supplied

Women with low libido: correlation of decreased androgen levels with female sexual function index.

The aim of the present study was to investigate a possible correlation between decreased androgen levels and female sexual function index (FSFI) in women with low libido and compare these findings with normal age-matched subjects. In total, 20 premenopausal women with low libido (mean age 36.7; range 24-51 y) and 20 postmenopausal women with low libido (mean age 54; 45-70 y), and 20 premenopausal healthy women (mean age 32.2; range 21-51 y) and 20 postmenopausal healthy women (mean age 53.5; range 48-60 y) as controls were enrolled in the current study. Women with low libido had symptoms for at least 6 months and were in stable relationships. All premenopausal patients had regular menstrual cycles and all postmenopausal patients and controls were on estrogen replacement therapy. None of the patients were taking birth control pills, corticosteroids or had a history of chronic medical illnesses. All completed the FSFI and Beck's Depression Inventory (BDI) questionnaires. Hormones measured included: cortisol; T3, T4 and TSH; estradiol; total and free testosterone; dehydroepiandrosterone sulfate (DHEA-S); sex hormone binding globulin (SHBG). We performed statistical analysis by parametric and nonparametric comparisons and correlations, as appropriate. We found significant differences between the women with low libido and the controls in total testosterone, free testosterone and DHEA-S levels and full-scale FSFI score for both pre- and postmenopausal women (P<0.05). In addition, decreased total testosterone, free testosterone and DHEA-S levels positively correlated with full-scale FSFI score and FSFI-desire, FSFI-arousal, FSFI-lubrication and FSFI-orgasm scores (P<0.05). Our data suggest that women with low libido have lower androgen levels compared to age-matched normal control groups and their decreased androgen levels correlate positively with female sexual function index domains.

Adult↗

PubMed2004

Libido as part of sexuality in female cancer survivors.

PURPOSE/OBJECTIVES: To present the state of knowledge and a suggested program of research related to one part of sexual functioning in female cancer survivors: libido. DATA SOURCES: Journal articles, monographs, and book chapters. DATA SYNTHESIS: Sexuality is a broadly defined term with many components. Libido is a component of sexuality and is reviewed with respect to definition, physiology, and measurement. Evidence-based interventions also are discussed. CONCLUSIONS: Most of the evidence related to enhancing libido involves testosterone, but this has not been tested in cancer survivors. Several clinical questions are yet to be answered regarding physiology as well as nonpharmacologic and pharmacologic interventions for enhancing libido. IMPLICATIONS FOR NURSING: Nurse researchers could add much to the evidence base on interventions for improving libido and, subsequently, sexual health. Implementing behavioral interventions to enhance libido would be an appropriate nursing function.

Antidepressive Agents↗

PubMed1989

The non-significant effect of feeding level, growth rate and age on libido of young Afrikaner bulls.

Afrikaner bulls (n = 30) between 9,5 and 15 months old, were allocated to 2 dietary treatments fed ad libitum. Diet 1 consisted of 70% concentrate and 30% Eragrostis curvula hay (11,4 MJ ME kg-1 DM) and Diet 2 of 40% concentrate and 60% E. curvula hay (9,3 MJ ME kg-1 DM). Five libido tests were conducted per bull between the ages of 16 and 28 months. Bulls were pre-stimulated for 10 min by close contact with previously synchronised oestrous heifers. Three bulls were then simultaneously allowed a period of 15 min with 6 heifers. Manifestations of libido were indexed as follows: 1. smelling heifer and definite signs of interest; 2. attempt to mount without erection; 3. mount with erection but no intromission; 4. successful service. Libido values fluctuated highly both within and between bulls. Libido did not improve over the 16 to 28-month age period nor with experience as successive tests were conducted. Bulls on Diet 1 grew significantly faster during the first 7,5 months of the trial, but demonstrated non-significantly higher libido scores. It was concluded that maturation over the 16 to 28-month age period, learning experience and level of feeding had no effect on libido.

Age Factors↗

PubMed1987

Active immunization of boars against gonadotropin releasing hormone. II. Effects on libido and response to testosterone propionate.

Of 20 sexually mature Duroc boars showing normal libido, 10 were actively immunized against gonadotropin releasing hormone (GnRH). After immunization against GnRH, boars showed minimal sexual interest in an estrous female, while untreated boars showed normal libido. Eight of the boars actively immunized against GnRH were randomly assigned to treatment (T) or control (C) groups. Boars in the T and C groups were given testosterone propionate or vehicle, respectively, on Days 0, 5, 10, and 15. Boars in both groups were observed for libido in the presence of an estrous female every 4 d for 28 d. Mean libido score for T boars increased gradually until all boars displayed maximum libido on Day 20, but libido returned to low levels on Day 28. In contrast, C boars remained sexually inactive throughout the study. The results of this study indicate that active immunization of sexually mature boars eliminates sexual behavior and that sexual behavior can be restored quickly by administering testosterone propionate.

Journal Article↗

PubMed1989

Breeding soundness, libido and performance of beef bulls mated to estrus synchronized females.

Ninety-three beef bulls and 2316 females were used to determine the relationships between breeding assessments of bulls and subsequent mating performance. Each bull was given a breeding soundness examination (BSE) and two 10-min libido/serving capacity (L/SC) tests. Breeding potential of each bull was classified as satisfactory (BSE score = 60 to 100) or questionable (BSE score = 30 to 59); libido was classified as either high (mean score = 9.0 to 10) or medium (mean score = 6.0 to 8.5). Bulls were then joined, single-sire, with groups of females which had received one of two treatments to synchronize estrus. Bull-to-female ratios ranged from 1:7 to 1:51. Continuous observations were conducted on the mating activity of each group. One bull was removed from the experiment due to a severe breeding problem. Bulls of satisfactory breeding potential (n = 80) did not differ (P > 0.10) from bulls of questionable breeding potential (n = 12) in measurements of mating activity. However, by the end of the synchronized breeding period, bulls classified as satisfactory breeders achieved approximately a 9% higher (P < 0.10) pregnancy rate than did bulls of questionable breeding status (45.6 +/- 2.1% vx 36.5 +/- 5.3%). Bulls with a high libido (n = 69) serviced more (P < 0.01) estrous females (81.3 +/- 3.1% vs 63.5 +/- 4.2%) than bulls with a medium libido (n = 23). However, pregnancy rates achieved by bulls of either libido classification did not differ significantly. Individual components of the BSE as well as mean libido score were poorly correlated with pregnancy rates (r = -0.22 to 0.18). It was concluded that classification of bulls by mean libido score can aid in identifying groups of bulls that service more estrus synchronized females, whereas classification by BSE score aids in identifying groups of bulls that impregnate more females.

Journal Article↗

PubMed2004

Genetic parameters of libido in Brazilian Nellore bulls.

Genetic, environmental and phenotypic correlations between libido, testicular measurements, body weight and semen traits were estimated by multiple-trait-restricted maximum likelihood (MTDFREML) under animal models. Reproductive records, collected from 1992 to 1997, of 288 Nellore bulls were used. Estimates of heritability for libido unadjusted, adjusted for scrotal circumference and adjusted for body weight, were 0.34 +/- 0.10, 0.31 +/- 0.10, and 0.19 +/- 0.11, respectively. Genetic correlations between libido and body weight, scrotal circumference, testis length, testis width, testis volume and testis consistency were, respectively, 0.69, -0.43, -0.31, -0.16, 0.10, 0.87, and between libido and semen volume, sperm motility, vigor, gross motility, major, minor and total defects were, respectively, 0.71, 0.51, 0.12, 0.16, 0.31, 0.26 and 0.43. Results suggested that selection for libido would be effective and that it would lead to desirable correlated response for scrotal circumference, physical and morphological semen traits and undesirable correlated response in body weight.

Animals↗

PubMed2000

Libido: the biologic scenario.

Libido is a comprehensive and yet elusive word that indicates basic human mental states--and their biological counterparts--involved in the beginning of sexual behavior. It has three main roots: biological, motivational-affective and cognitive. All these dimensions may be variably affected in the post menopause, contributing to a progressive decrease of sexual drive that parallels the process of aging. Loss of estrogens and, specifically, of androgens deprives female libido of major biological fuel. The effect of this loss is pervading, affecting the central nervous system, the sensory organs that are the major windows to environmental sexual stimuli and the quality of sexual response, central, peripheral non-genital and genital. Prolactin increase may further inhibit libido. Arousal disorders, dyspareunia, orgasmic difficulties, dissatisfaction, both physical and emotional, may contribute to a secondary loss of libido. Depression, anxiety and chronic stress, may interfere with central and peripheral pathways of the sexual response, reducing the quality of sexual function mostly in its motivational root. Relational conflicts and/or marital delusions and partner-specific problems, erectile deficit first, may contribute to the fading of sexual drive in the post-menopausal years. Well tailored HRT, including androgens in selected cases, may reduce the biological causes of loss of libido. A comprehensive treatment requires a balanced evaluation between biological and psychodynamic factors.

Androgens↗

PubMed1990

Libido, hormone concentrations in blood plasma and semen characteristics in Holstein bulls.

Relationships among bull libido, serum hormone concentrations and semen characteristics were studied using 18 Holstein bulls that were 4 to 5 yr old. The hormones studied included testosterone, estradiol (E2), prolactin (PRL), LH and cortisol. Two ejaculates were collected three times per week from each bull during a 5-wk trial. During the last week of the trial, on a day semen was not collected, blood was collected from indwelling catheters every 15 min for 6 h to determine the hormonal profiles of each bull. On the following day, blood was sampled every 10 min before and after the time of semen collection. Libido factors were quantified, and semen volumes and sperm concentrations were recorded. The libido factors included reaction time to first service, latency time between the first and second semen collections, and duration of time the bull mounted the teaser prior to the first (TM1) and second (TM2) semen collection. Average reaction and latency times were correlated (r = .524; P = .026), as were TM1 and TM2 (r = .597; P = .015). Latency times were correlated with average TM2 (r = .669; P = .003). Average PRL concentrations were correlated with average latency times (r = .467; P = .05). Low libido bulls tended to have higher E2:testosterone ratios than did high libido bulls. Both PRL and cortisol concentrations increased at semen collection.

Animals↗

PubMed2002

Loss of libido in menopausal women. Management issues.

BACKGROUND: Due to a complex interplay of sociocultural factors, past experiences, relationships and hormones, a woman's experience at menopause and beyond is highly individual. A variety of external, often stressful, life events can be occurring at this time in a woman's life, all impacting on her individual symptom profile. Menopause is a natural event in a woman's life cycle and loss of libido may be one of a multitude of symptoms experienced around this time. In fact, the decline in sexual interest commonly precedes the onset of a natural menopause, even though many women do not report their loss of libido until the menopause, when symptoms may be exacerbated. OBJECTIVE: To review contributing factors and treatment options available for menopausal women experiencing loss of libido. DISCUSSION: With increasing awareness, knowledge and discussion about sexual health issues, there are an increasing number of women seeking advice and treatment for low libido. The introduction of the oral contraceptive pill in the '60s; the increasing use of HRT for menopausal symptoms; the availability of drugs such as sildenafil; the recent acknowledgement and definition of the 'female androgen insufficiency syndrome' are all factors which have contributed to the so-called 'sexual revolution' whereby women and their doctors--are able to feel more comfortable discussing their sexual concerns. Nevertheless, many women will not volunteer this information and it is advisable to specifically ask about libido and associated symptoms of mood and well being.

Female↗

PubMed2005

Breeding soundness and libido examination of Belgian Blue and Holstein Friesian artificial insemination bulls in Belgium and The Netherlands.

Data on breeding soundness and libido evaluations in Belgian Blue (BB) bulls are scarce. The present study compared results of breeding soundness and libido evaluations of young BB bulls to young Holstein Friesian (HF) bulls prior to acceptance into an AI program. Breed differences for breeding soundness exist between BB and HF bulls, as 93.7% of the young BB bulls failed the breeding soundness examination (BSE) compared to 59.3% of the HF bulls (P=0.0005). Within the BB breed, differences were present between bulls of different ages, and bull selection for better fertility with increasing age apparently influenced the results. The number of reasons for which bulls failed the test differed between the age groups in the BB breed, whereas a tendency for more failure reasons in the BB breed was noticed in the breed comparison. The most important reasons for failure were sperm morphology and scrotal circumference (SC), but far more BB bulls failed for these traits compared to the HF breed (82.8% versus 56.0% and 43.8% versus 17.6% in the BB and the HF breed for sperm morphology (P=0.0005) and SC (P<0.0001), respectively). The high proportion of BB bulls with a substandard SC and poor sperm morphology might suggest an increased prevalence of testicular hypoplasia or degeneration within this breed. Concerning libido, the reaction time did not differ either between breeds or between age groups within the BB breed, whereas mounting enthusiasm, although not different between the two breeds, did decline with increasing age, probably due to the greater mating experience of the older bulls. All in all, libido did not seem to be different between the breeds.

Age Factors↗

PubMed2001

Disinhibition of libido: an adverse effect of SSRI?

BACKGROUND: The article focuses on adverse drug reactions (ADR) to selective serotonin reuptake inhibitors (SSRI) concerning libido and sexual behaviour: cases of disinhibition of libido observed at the Psychiatric Hospital of Kilchberg near Zurich are described. METHOD: Within the scope of a drug safety program, the physicians of the hospital are regularly asked about severe and unexpected events under drug treatment. RESULTS: During remission of depression, five outpatients noticed an increase of libido experienced as strange to them, i.e. preoccupation with sexual thoughts, first appearance of promiscuity, of unsafe sexual intercourse, and of excessive pursuit of pornography, respectively, during administration, change in dose or discontinuation of SSRI. DISCUSSION: The case studies suggest that SSRI treatment might be associated with increase and disinhibition of libido. The phenomena are discussed as a "selective switch" into partly manic symptomatology or an induction of mixed states with prevailing sexual symptoms.

Adult↗