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At least 19 recordsLinked to original sources
PubMed1977

Altered schistosome granuloma formation in nude mice.

Schistosome egg-induced lesions in congenitally athymic mice differed from those found in normal heterozygous controls. Heterozygote liver granulomas were chareacterized by poorly phagocytic epithelioid macrophages, and were rich in eosinophils and fibroblasts, with peripheral lymphocytes and plasma cells. Hepatic lesions in nude mice were much smaller and lacked epithelioid macrophages, with lesions about mature eggs, typically consisting of monocytes and macrophages filled with pigment, occasional neutrophils, and rarely one or more eosinophils or giant cells. While heterozygote granulomas damaged liver cells mainly by encroachment or by their vascular effects, in the nudes hepatocytes bordering the lesions showed microvesicular cytoplasmic damage and either hydropic degeneration or focal acidophilic necrosis of individual liver cells. In heterozygotes, immunofluorescent-stainable schistosome egg antigen (SEA) was concentrated in the granuloma center. In nude mice, SEA, was distributed throughout the infiltrates and in and around hepatocytes adjacent to egg lesions corresponding to the observed pattern of hepatocyte necrosis. We conclude that, in contrast to heterozygotes, nude mice lack hypersensitivity granulomas and fail to sequester toxic egg products, this resulting in zonal hepatocellular damage. Alternative explanations include the possibility of a latent hepatitis virus being activated by the schistosome infection; however, several cogent arguments are presented against that alternative.

Animals↗
PubMed1978

Ascariasis.

Explore the source record for details and available documents.

Ascariasis↗
PubMed1976

[The effect of dehelminthizations performed during the year on the seasonal dynamics of natural nematode infections in sheep].

In four sheep flocks of two age categories dynamics of natural infections by pulmonary and gastrointestinal nematodes was studied; sheep were kept on a farm in Western Bohemia. Dehelminthizations were performed in different intervals during the grazing period on the basis of the results of quantitative coprologic examinations. Total effectiveness of 80--100% intenseffectiveness (IE) was obtained as a result of single peroral or intraruminal dehelminthization with the following preparations: pyrantel hydrochloricum (Spofa), helmatac (SKF) and nilverm (ICI); the effectiveness concerned gastrointestinal nematodes of the genus Haemonchus, Cooperia, Ostertagia, Trichostrongylus, Bunostomum, Chabertia, Nematodirus, Strongyloides, Oesophagostomum and Trichocephalus. The effectiveness of nilverm on lungworms of D. filaria and P. kochi reached 100%; the preparation was less effective and ineffective on M. capillaris. Dehelminthization practices during three years were more successful as to lowering of incidence of lungworm infections of D. filaria and P. kochi than in gastrointestinal nematodes. If sping dehelminthizations had been postponed till the second half of May or June, the climax of the elimination of ova from summer re-infection was put off till November, with an initial significant increase in September. The third dehelminthization, applied in August, did not result in the increased elimination of ova in autumn, while there was no usual autumnal climax following September dehelminthization. Effective dehelminthization performed at the end of November in all three years maintained low levels of infections during winter housing and significantly influenced the health conditions of ewes before lambing. Dynamics of the elimination of ova after dehelminthization was affected by nematodes with the migration phase in organs and tissues -- S. papillosus, Oesophagostomum sp. and Ostertagia sp.; the same effect was observed, during pasture, in nematodes with relatively short exogenous development of the genus Haemonchus, Ostertagia, Trichostrongylus and Nematodirus. In spite of these dehelminthization practices, the elimination of ova and larvae corresponded to the course of temperatures and rainfall in spring and autumn climaxes every year.

Animals↗
PubMed1979

Histopathology of hepatic and pulmonary granulomata experimentally induced with eggs of Schistosoma mansoni.

Hepatic granulomata were experimentally induced in previously unexposed white mice, albino rats and golden hamsters by injecting viable exogenous eggs of Schistosoma mansoni via the mesenterico-portal system. Histopathologic studies of livers of these animals showed that the lesions were similar to those in infections resulting form exposure to cercariae as occurs naturally in Mansonian schistosomiasis. Comparable observations made of the lungs of animals that had received egg injections via their tail veins, showed striking differences with respect to timing of the occurrence of various histopathologic stages, mean size of granulomata, cellular composition and pathologic manifestations.

Animals↗
PubMed1975

[Effect of fenbendazole (Panacur) in sheep naturally invaded by gastrointestinal and lung nemtaodes].

The paper presents the results of the clinical tests of fenbendazole (Panacur, produced by Hoechst, F. R. G.), a new antihelminthic preparation. The tests were performed in sheep naturally invaded by gastrointestinal and lung nematodes. Helminthological dissection performed 7 days after the application of 5 mg of fenbendazole per 1 kg of sheep weight proved 100% effectiveness on lungworms (Dictyocaulus filaria) and on the following gastrointestinal helminths: Ostertagia ostertagi, Haemonchus contortus, Bunostomum trigonocephalum, Strongyloides papilosus, Chabertia ovina, Oesophagostomum venulosum, Trichostrongylus spp., and Nematodirus filicollis. The effect on the Trichocephalus ovis species was low and statistically insignificant (37.8%). The tolerance to the chemical was good even in sheep in a very bad condition.

Animals↗
PubMed1979

Pulmonary function studies in acute pulmonary histoplasmosis.

We performed follow-up pulmonary function studies on three patients with acute pulmonary histoplasmosis over a period of several months, and found that the disease is benign and usually responds well to treatment or is self-limiting. There are four major changes in lung function, namely a restrictive defect, an impairment of diffusing capacity, stiff lung, and obstruction in small airways. These changes usually lead to disturbance of ventilation-perfusion ratios and impaired gas transport across alveolar capillary membranes, resulting in arterial hypoxemia. There is also hypocapnia from alveolar hyperventilation commonly found in restrictive and stiff lung syndrome.

Adult↗
PubMed1975

[Acute non-tuberculous military lung].

The authors report the case of a young woman with acute miliary appearance of the lung with asphyxia, from which she rapidly recovered. No cause was demonstrated; this illustrates the difficulty in diagnosis of this disease. Contact with a bird, led the authors to consider exogenous, allergic granulomatosis, but immunological examinations did not confirm this. Apart from tuberculosis, almost 50 different pathogenic organisms may cause acute respiratory failure associated with a miliary or reticulo-nodular appearance of the lung. The main methods of diagnosis are discussed in relation to the most commonly observed causes in France.

Acute Disease↗
PubMed1977

Human serum monoamine oxidase.

A study on serum monoamine oxidase (MAO) levels in fibrotic disease processes led us to investigate patients with moderate to severe burns. Strikingly low serum MAO activity was found in patients with relatively recent, severe injuries. So far, we have no explanation to offer for the phenomena observed.

Burns↗
PubMed1978

Clinical pulmonary perfusion imaging in the dog.

Scintigraphic pulmonary perfusion imaging in the dog has been described for the clinically normal animal. The usefulness of this technique in the patient with pulmonary dysfunction was assessed by review of 76 consecutive clinical cases completed in a 6-month period. This review indicated that 3 basic patterns of perfusion defects are commonly seen in the dog. These were associated with (1) diffuse parenchymal metastatic disease, (2) mediastinal metastatic disease, and (3) heartworm disease. The technique has proved reliable as an aid in the staging of neoplastic disease and of some potential value in heartworm disease and is now performed on a routine basis at this institution for purposes of clinical diagnosis.

Animals↗