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At least 19 recordsLinked to original sources

[A contribution to the pseudo-LE-syndrome. Investigations of the cardiovascular system, abdominal organs, lymphatic system and drug histories (author's transl)].

13 of 30 patients suffering from pseudo-LE-syndrome showed a usually reversible enlargement of the heart during the acute stage of the disease. In two patients carditis occurring in pseudo-LE-syndrome lead to congestive heart failure and an additional patient died in the acute stage of carditis. As opposed to Systemic Lupus Erythematosus hypertension did not occur in a higher frequency than normal. In five cases cardiac catheter examinations showed slight elevation of the end-diastolic pressure in the right ventricle, in two cases an abnormal high mean pressure in the right atrium and a systolic gradient at the pulmonic valve was found. -Scintigrams showed definite enlargement of the spleen and to a lesser degree enlargement of the liver was seen. Laparascopy showed multiple concretions after peritonitis. Lymphographic changes in the retroperitoneal lymph nodes and lymphatic ducts were not observed in contrast to rheumatic diseases. Drug histories in most cases discovered intake of Venopyronum dragees prior to onset of the disease. But recurrent attacks of the disease also occurred without further intake of the drug.

Adult

[Current methods for investigation of the lymphatic system (author's transl)].

Investigation of the lymphatic system attracts an ever increasing interest not only of scientists working in the theoretical field but also of clinicians. Therefore it is no wonder that numerous methods for the study of the lymphatic system have been proposed. The present article surveys a great number of these methods, and particular emphasis is given to the work that has been and is being carried out in the Soviet Union. It is shown that a detailed knowledge of the lymphatic system is essential if a holistic view of the structure and function of a particular organ is to be obtained.

Animals

Diagnostic evaluation of the pelvic and abdominal lymphatic system.

Evaluation of the pelvic and abdominal lymphatic systems is the subject of renewed interest by radiologists, radiotherapists, surgeons and medical oncologists. The primary reason for this interest has been the rapid advance of diagnostic imaging technology, particulary in ultrasonography and computerized tomography (CT). Another reason is the realization that with some neoplasms, particularly gynecologic neoplasms, there has been little progress in long-term survival in spite of aggressive local management. A possible explanation for this is "understaging" of neoplasms by previous radiologic procedures. Although lymphangiography has a proved and well-defined place in the diagnostic regimen, it remains tedious, time-consuming and invasive. Gray-scale ultrasound and CT have been widely used for several years and their role, limitations and relationship to lymphangiography have become established. The purpose of this monograph is to provide a short review of the lymphatic system and lymphangiogram, with particular attention to the recent radiologic literature. The role and limitations of the various diagnostic modalities are discussed and the lymphatic drainage and common pelvic neoplasms (as approached in the recent literature) are reviewed. No attempt has been made to define the lymphatic drainage of abdominal visceral organs.

Female

[Cytokinetics of lymph nodes in lymph nodes in lymphatic system diseases (author's transl)].

Untreated malignant lymphatic system diseases are characterized by a preponderance of cell new formation (proliferation) against the destruction of lymphatic cells. If the lymph nodes are enlarged during these diseases, then cell new formation occurs largely or mostly in these lymph nodes. The proliferating cells of the lymph node are bigger than small lyphocytes and have, in general, a mean diameter of the nucleus of 10 mu and more. In normal lymph nodes they belong morphologically to the big lymphocytes, immunoblasts and plasmoblasts. In pathological lymph nodes they have to be looked for among the bigger cells of the disease-specific cell population. Whereas in healthy lymph nodes and in chronic lymphatic leukemia only about 1% of lymph node cells was found to proliferate, they amount on the average to 5% in lymphomas of lymphogranulomatosis and mostly to 30--50% in the lympho-reticulosarcoma (lymphoblast and immunoblast sarcoma, corresponding to large-cell, poorly differentiated lymphomas). The proliferating cells often appear as foci in the lymphomas. The generation times of the proliferating cells both in normal and pathological lymph nodes are about 24 hrs. or slightly longer. In lymphatic proliferation, apart from plasma cells big and smallymphocytes are produced in the normal lymph node; in CLL, big and small lymphocytes, in lymphogranulomatosis, big and small lymphocytes and Hodgkin-cells, and in poorly differentiated lymphomas, the corresponding lymphoma cells are produced. The clinicist is at the beginning of drawing conclusions from prevalent kinetic disturbances.

Cell Division

Prenatal diagnosis of fetal lymphatic system abnormalities by ultrasound.

Antenatal ultrasound diagnoses of gross lymphatic system abnormalities were made in three fetuses. Although the diagnosis was made in only 1 fetus at a stage early enough in pregnancy to allow selective termination, knowledge of the abnormality in the remaining 2 fetuses proved to be valuable for subsequent management of those pregnancies. It is stressed that the extent of the abnormality must be carefully assessed because of the possibility of corrective surgery should the lesion be small and that the parents must be given detailed counseling before any definitive measures are taken.

Abortion, Therapeutic

[Behavior of the local lymphatic system after aorta-iliaco-femoro-popliteal reconstruction].

As a result of the observation of oedemas of the lower extremities and lymphorrhoea in the immediate postoperative course of surgical reconstruction of the aorto-iliaco-femoro-popliteal arterial axis (and on the basis of similar cases in the literature), the participation of the lower extremity return circulation in this facet of vascular surgery has been documented. The venous system was never impaired whereas the local lymphatic system was always damaged by surgical aggression on the arterial vessels. However, the extensive anatomical lesions shown up by lymphography are not reflected in evident clinical signs; whenever oedema or lymphorrhoea of the surgical wounds are observed, these symptoms are always of slight importance and easily and quickly resolved. At long-term follow-up, no clinical evidence of impairment ot the venous and lymphatic venous return circulation was ever encountered. For prophylactic purposes the lymphatic structure encountered during the operation should be carefully ligated to counteract another dangerous complication: infection.

Aorta

[Attempt at treating multiple sclerosis by means of ultrasound stimulation of the lymphatic system].

The authors tried to apply ultrasound stimulation of the lymphatic system in patients with multiple sclerosis. This trial was undertaken in view of reports of German authors on favourable results of this therapeutic method. The treated group included 24 patients aged 20--54 years with steady or slowly progressive course of this disease in whom spastic paraparesis predominated in the clinical picture. Before starting and after the completion of this treatment each patient was examined and graded according to a 65-point scoring system taking into account the most important clinical parameters. After 4--6 months in 15 patients the course of treatment was repeated. One course of treatment included 24 procedures performed once daily. The procedure and technical data are described. The results obtained were as follows: 80% of patients reported subjective improvement, the objective status was improved by a mean value of 19% after the first course of treatment and 5% after the second treatment in relation to the initial state. Apart from some somnolence in the initial period of the course, no other side effects were observed. This report is regarded by the authors as a preliminary communication since for a better evaluation of this method the courses of treatment should be repeated several times and in a greater number of patients.

Adult

Morphology of the intrarenal lymphatic system. Capsular and hilar communications.

Recent functional evidence has indicated that ureteric obstruction for three or more days in dogs causes a diversion of renal lymph from the hilar to the capsular system. The present study was concerned with the structural correlate of this functional evidence, having special reference to communications between the two systems. Within three days of ureteric occlusion the capsular lymphatic system became dilated. On histological examination two types of tributaries were found. One (termed a perforating lymphatic) served as a primary pathway for superficial cortical lymph from the subcapsular plexus, and penetrated the capsule either alone or in company with a small vein. The other (termed a communicating lymphatic) was closely associated with the occasional penetrating interlobular blood vessel which traversed the capsule to ramify in the perirenal tissue. Approximately 60% of the penetrating arteries in eight dog kidneys had associated communicating lymphatics. On the renal surface the perforating and communicating lymphatics formed the primary collecting vessels of the capsular system. Within the renal substance the communicating lymphatics were directly continuous with lymphatics which surrounded the interlobular blood vessels and which have been shown to drain into the hilar network. Thus the communicating lymphatics formed direct connections between the hilar and capsular systems. It was concluded that these communications, although dilated by hydronephrosis, existed under control conditions. Functionally they are probably of importance only under special circumstances when intrarenal lymph may be diverted from one to the other system.

Animals

[Effect of vibration on the functioning of the lymphatic system in the small intestine in rat].

The production rate and flow of the lymph in mesenteric lymph vessels under normal conditions and after horizontal vibration of 5 Hz frequency and 20 mm amplitude were measured by means of intravital, intravenous injection of trypan blue water solution. The investigations were carried out on 66 Wistar rats of both sexes. It was found, that 3 and 7-hour vibration and everyday 7-hour vibration applied during a week result in the acceleration of lymph flow, whereas 3- and 4-week vibrations result in reduction of production and flow of the lymph. In all cases the lymph flow speed becomes normal after one day break. The results obtained show that low frequency vibration causes reversible functional changes in small intestine lymphatic system. These changes more probably result from hemodynamic disturbances. The applied vibration parameters did not cause any perceptible morphological changes in the lymphatic system.

Animals

The terminal pathway of the lymphatic system of the human heart.

Aantomical dissections in 9 human cadavers revealed the terminal pathway of the lymphatic system of the left ventricle to be constituted mainly by channels emptying into the right angulus venosus (junction of the internal jugular and subclavian veins) at the base of the right side of the neck. This observation has clinical implications because it has been shown that a sampling of cardiac lymph provides the best method for analyzing myocardial metabolic abnormalities and that drainage of cardiac lymph alleviates the myocardial changes produced by ischemic injury.

Adult

Distribution and fine structure of the lymphatic system in the human testis.

The distribution of lymph vessels in the human testis was investigated using ink injection methods, and light and electron microscopy. Lymph capillaries occur in the septula testis but are absent in the intertubular tissue. They consist of endothelial cells provided with an incomplete basal lamina and anchoring filaments of the adjacent connective tissue. Frequently, the endothelial cells are separated by gaps measuring up to 2 micron. The lymph capillaries of the septula testis are connected to lymph vessels in the rete testis and tunica albuginea. These vessels have occasional smooth muscle cells and valves. At the posterior margin of the testis, the network of lymph vessels merges into collecting ducts, which together with vessels derived from the rete testis are drained by the lymphatic system in the spermatic cord.

Endothelium

Distribution and density of the canine renal cortical lymphatic system.

The pattern, distribution, and extent of the lymphatic circulation in the canine renal cortex was studied with light and electron microscopy, in two groups of animals, one with and one without ipsilateral ureteric obstruction for 3 days. Recognition of lymphatics in tissue sections was facilitated by mild dilatation, induced in both groups by ligation of the renal collecting vessels for 4 to 6 hours, and by retrograde injection of tracer in a third group. Of 77 lymphatics present in 180 blocks from six kidneys, approximately one third were intralobular, the remainder being primarily associated with interlobular blood vessels. The cross-sectional area of interlobular lymphatics was almost twice that of intralobular lymphatics. The relationships of these lymphatics were analyzed quantitatively. Intralobular lymphatics had primary relationships with terminal arteries, arterioles, renal corpuscles, and tubular elements. Both inter- and intralobular lymphatics had secondary relationships with a small proportion of all components of the cortical parenchyma including juxtaglomerular complexes. The most common association was between lymphatics and elements of the vascular tree. Morphometric analysis was used to obtain volume density data on the composition of the renal cortex. The volume density of lymphatics was 0.0026 in ureter-obstructed kidneys and 0.0017 in nonobstructed kidneys. The cross-sectional surface area of lymphatics in ureter-obstructed kidneys was significantly larger than those in nonobstructed kidneys. The volume density of other cortical components was found to be in good agreement with published data. From the volume density data, it was concluded that the volume of lymph in the renal cortex, under conditions of mild lymphatic dilatation, was about 1% that of the volume of blood in the cortical peritubular capillaries.

Animals