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At least 19 recordsLinked to original sources
PubMed1976

[Epidemiologic analysis morbidity with meningococcal infections in the USSR].

The authors present the analysis of the incidence of epidemic cerebrospinal meningitis in the USSR from 1937 to 1974, and of meningococcus infection from 1965 to 1974. A rise of the meningococcus infection incidence from 1969 to 1974 was recorded 28 years after the elevation of 1940-1942 and was 1.5 times below this latter rise. The rise in 1969-1974 was characterized by marked signs peculiar to the infection with the droplet transmission mechanism; among those who contracted the disease prevalence was seen among children aged under 14 years (63-72%). A marked affection of juveniles was noted. Three types of the dynamic of the meningococcus infection incidence in the republics located in different climatic-geographical zones of the USSR were noted: slow, gradual increase of the level, interrupted and explosive. Such character was determined in the dynamics of the seasonal elevations of morbidity. Antiepidemic measures including a complex of nonspecific measures could not be assessed as sufficiently effective. This finds reflection in the natural course of the epidemic process of the meningococcus infection which remains uncontrolled. From the patients with generalized form of the disease meningococci of group A were isolated in 80-100% of cases, from the number of those typed. The group-specific reference of the nasopharyngeal strains depended on the epidemic situation: strains of serological group A prevailed at the period of the morbidity elevation, and other serological groups (particularly of C and B) increased at its decline.

Adolescent↗
PubMed1978

[Incidence of meningococcal infection in the RSFSR].

The authors present characteristics of meningococcus infection epidemic process in case of sporadic cases and under epidemic conditions (1965--1976). A scheme of epidemiological analysis suggested by the authors permitted to differentiate and to record the incidence of various clinical forms of meningococcus infection, to present data on the age, seasonal characteristics, focality, etc. Comparison of intensive morbidity indices for 10 years, both at the individual administration territories and in the Republic as a whole demonstrated morbidity level of 1.5--2.0 to be one of prognostic signs of the beginning epidemic. The main features differentiating the sporadic and epidemic morbidity periods were revealed. The presence of group diseases, a greater percentage of children among those who fell ill, and marked signs of seasonality and territorial difference characterized the period of rise caused by meningococcus of serological group A.

Adolescent↗
PubMed1978

[Dynamics of humoral immunity indices in patients with the generalized form of meningococcal infection].

A possibility of using the passive hemagglutination test with meningococcus diagnostic agents of groups A and C for observing the changes in the infectious process was demonstrated. Sera of patients with generalized form of meningococcus infection showed an increase (by the 2nd--3rd week) and a rapid reduction (by the 4th week) of the specific antibodies titres to the levels seen during the first days of the disease. At the remote periods after the disease--in 2 to 5 years--hemagglutinins were revealed in the same titres as in healthy persons (1:10--1:13). Study of physico-chemical nature of antibodies demonstrated that at the early stages of meningococcus infection there formed antibodies referred chiefly to macroglobulins, and at the remote periods (after 3 months)--to microglobulins.

Adolescent↗
PubMed1978

[Detection of the etiologic structure of generalized and localized forms of meningococcal infection using the passive hemagglutination test].

Preparations of formalin-treated erythrocytes sensitized with meningococcus polysaccharides of serological groups A, C, X, Y, and Z were used for the purpose of examination of patients with meningococcus infection; these preparations were highly specific in the tests of precipitation, hemagglutination and hemagglutination inhibition. Indirect hemagglutination test with the sera of 99 patients suffering from generalized forms of meningococcus infection was conducted with the mentioned preparations in Moscow and Novosibirsk in 1974--1975 when a stable morbidity decline was noted in these towns after an epidemic rise. The diagnostic value of this test was confirmed: it permitted to diagnose meningococcus etiology beginning from the 5th day of the disease and to decipher it from the aspect of individual serological groups. As shown, the incidence of cases caused by serological group A, reaching 87% at the height of the epidemic rise, fell to 49.5% at the stage of decline. Cases caused by group Y which was not encountered formerly were revealed in 16.2% of the patients. Among 127 patients with miningitis of nonmeningococcus etiology meningococcus antibodies to groups A and Y were revealed with the same frequency (in titres of not over 1 : 20--1 : 80), but the leading role of serological group A in the etiology of the manifest forms permitted to draw a conclusion on the presence of a higher invasiveness in the strains of group A.

Hemagglutination Tests↗
PubMed1975

[Results of a controlled epidemiological trial of the application of placental gamma globulin in foci of meningococcal infection].

Controlled epidemiological trial was applied to the study of the use of placental gamma-globulin for prophylaxis of generalized forms of meningococcus infection in the foci (creches and kindergartens). A group of the vaccinated children (16 140) and control group (16 080) were the same age and sex. Gamma-globulin was administered in a dose of 3 ml to every other child attending creches and kindergartens not later than the 10th day after the patient's isolation. It was shown that the efficacy coefficient of gamma-globulin in the foci of meningococcus infection constituted 68% (the efficacy index was 3.2) for one month after the administration.

Child↗
PubMed1976

[Role of meningococcal carrier state in formation of the immunologic structure of a collective with regard to that agent].

The authors present the results of the immuno-epidemiological studies of two collective bodies -- over 2000 persons in all -- equal by age composition and physical load, who were under the same sanitary-hygienic conditions. Observations were carried out from the time of formation of these collective bodies in November and were continued for a period of 6 months; they differed by the epidemic situation in respect to the meningococcus infection, i.e. cases of this disease and carriers were present in the first, and carriers only in the second group. The collective bodies were subjected to complete bacteriological examination (at the time of formation and in 3 and 6 months); blood was studied for the presence of antibodies to the complex meningococcus antigens of groups A, B and C (in the passive hemagglutination test.) There proved to be a marked increase in the percentage of positive tests with the A- and C-antibodies in both collective bodies and an increase in the number of positive tests with B-antibodies only in the collective body with no meningococcus cases. Since in the first collective body the percentage of generalized meningococcus infection cases was insignificant (about 0.85%) and there were no cases in the second collective body, a conclusion could be drawn that changes in the immunological indices among persons in these groups were caused by carrier state. Thus, the effect of meningococcus carrier state on the formation of immunological indices of collective bodies was revealed.

Adolescent↗
PubMed1976

[Use of the passive hemagglutination test for diagnosis of meningococcal infection].

A considerable percentage of patients with meningococcus infection displayed an increase in the actibody titres to meningococcus, group A, detectable in the passive hemagglutination test (PHAT). An increase in the antibody titre was mose frequent in the patients with clinical manifestations of meningococciemia and meningitis. The PHAT can be used as an auxiliary method of diagnosis permitting to establish the meningococcus etiology of the disease in a number of cases.

Hemagglutination Tests↗
PubMed1984

Mechanism of impaired iron release by the reticuloendothelial system during the hypoferremic phase of experimental Neisseria meningitidis infection in mice.

Hypoferremia, the reduction of plasma transferrin iron levels during infection, has been shown to control Neisseria meningitidis infection in mice. The exact nature of the mechanism that regulates this response has been obscure. We have previously shown that hypoferremia does not result from an accelerated removal of iron from the plasma transferrin pool. In this study, we have examined the processing of iron by the reticuloendothelial system during infection. Normal and hypoferremic meningococcus-infected mice were injected with 59Fe-labeled erythrocytes. Kinetics of uptake and redistribution of the label indicated that during the hypoferremic phase of the infection, reticuloendothelial system-processed iron was not returned to the plasma transferrin pool. Fractionation of hepatic cellular compartments showed that this impaired release of iron resulted from a preferential incorporation of heme-derived iron into the intracellular ferritin pool during the hypoferremic phase of the infection. These findings indicate that this withholding of iron within the intracellular pool leads to hypoferremia and therefore denies the extracellular pathogen its essential iron.

Animals↗