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At least 19 recordsLinked to original sources
PubMed1964

SEROLOGY OF THE MIMA-HERELLEA GROUP AND THE GENUS MORAXELLA.

Mitchell, Paul D. (West Virginia University Medical Center, Morgantown), and Robert G. Burrell. Serology of the Mima-Herellea group and the genus Moraxella. J. Bacteriol. 87:900-909. 1964.-The identity of organisms which have been assigned to the Mima-Herellea group of the tribe Mimeae and their taxonomic position are uncertain. In considering the possible relationship of the Mima-Herellea group to the genus Moraxella, the approach used was the isolation and identification of representative antigenic constituents of strains designated Mima polymorpha, M. polymorpha var. oxidans, Herellea vaginicola, Moraxella lwoffi, M. liquefaciens, M. non-liquefaciens, and Bacterium anitratum. Cell-free extracts of sonically disrupted cells were used in these studies, and the precipitinogens derived by this method were considered to be of capsular and somatic origin. Identity among the strains was established by immunodiffusion, with immune sera and antigenic extracts. Heterologous and homologous reactions were performed with adsorbed and unadsorbed sera to verify the cases of identity. In every instance of homologous reaction, at least five distinct antigen-antibody systems were discernible within the Mima-Herellea group. However, as evidenced by heterologous studies, the demonstrable antigenic composition varied among the species and, in some instances, among the strains. M. polymorpha var. oxidans appeared to be serologically distinct from H. vaginicola and M. polymorpha, whereas strains of the latter two organisms were theorized to be closely related serologically. Serological cross-reactions in heterologous studies and reciprocal adsorption tests revealed the existence of a serological relationship between members of the Mima-Herellea group and the genus Moraxella. A tentative scheme of identity is postulated on the basis of these crossreactions and cultural and biochemical reactions among the designated strains of Herellea, Mima, Moraxella, and Bacterium.

Acinetobacter↗
PubMed2002

MIMA-9, a valuable antibody for screening for rare donors.

Since monoclonal antibodies (Mabs) are potentially available in an unlimited volume, they can be used to screen numerous donor blood samples to identify antigen-negative donors. We have used a Mab (MIMA-9) with characteristics that allow for the simultaneous screening of RBCs of any ABO group for high-incidence antigen-negativity in the Kell and Gerbich blood group systems. MIMA-9, a murine IgG2a antibody, previously shown to facilitate the identification of K+k-, Kp(a+b-), K0, McLeod, or Ge:-3 red blood cells (RBCs), was used in MTS gel cards containing anti-mouse IgG as the second antibody to test 1134 K- donors. Among the 1134 donors tested, we found one Kp(a+b-) and one Ge:-2,-3,4 donor. If random donor samples had been used instead of preselecting for K-, we would have expected to identify two K+k- donors. One reagent (MIMA-9) can be used to simultaneously screen for K+k-, Kp(a+b-), K0, McLeod, and Ge:-3 RBCs and thereby conserve rare antisera. Inclusion of anti-mouse IgG in gel cards allowed for rapid screening. MIMA-9 is also a useful reagent to type RBCs with a positive direct antiglobulin test. This antibody is available to donor screening laboratories at no cost for this specific use.

Journal Article↗
PubMed1963

Mima polymorpha infection.

Two cases of human infection by Mima polymorpha are described. From these cases, and from the literature, it is concluded that this species is heterogeneous with respect to its biochemical properties. From comparative studies it is concluded that the genus Mima is unrelated to the genus Moraxella or to Bacterium anitratum.

Acinetobacter↗
PubMed1966

Carbohydrate catabolism of Mima polymorpha. I. Supplemental energy from glucose added to a growth medium.

Bell, Emily J. (University of Cincinnati, Cincinnati, Ohio), and Adrienne Marus. Carbohydrate catabolism of Mima polymorpha. I. Supplemental energy from glucose added to a growth medium. J. Bacteriol. 91:2223-2228. 1966.-Mima polymorpha, unable to grow in the presence of nonphosphorylated sugars as sole source of carbon and energy, grows rapidly and well in the presence of acetate, ethyl alcohol, short-chained fatty acids, and permeable intermediates of the tricarboxylic acid cycle. Chemical evidence indicates, however, a limited uptake of glucose. Further, glucose, although incapable of supporting growth as the sole source of carbon and energy, does increase both the rate of growth and the total cell crop when added as an ancillary nutrient to cells growing in a mineral salts medium which contains 0.03 m acetate as the carbon and energy source. A yield of energy from an abortive catabolism of glucose is hypothesized. In addition to the enhancement of growth rate and total cell crop, this hypothesis is supported by the facts that: (i) transport systems for the slightly permeable phosphorylated hexoses appear to be induced when glucose is incorporated into a medium capable of supporting growth and (ii) the rate of induction and the total activity of an inducible enzyme, isocitrate lyase E.C. 4.1.3.1., are markedly increased in the presence of supplemental glucose.

Acetates↗
PubMed1966

Carbohydrate catabolism of Mima polymorpha. II. Abortive catabolism of glucose.

Marus, Adrienne (University of Cincinnati, Cincinnati, Ohio), and Emily J. Bell. Carbohydrate catabolism of Mima polymorpha. II. Abortive catabolism of glucose. J. Bacteriol. 91:2229-2236. 1966.-Mima polymorpha, unable to grow in the presence of glucose as a sole carbon and energy source, is able to obtain supplemental, utilizable energy from the partial catabolism of this substrate. Various enzymes of hexose catabolism have been assayed in this organism and in M. polymorpha M, a mutant obtained by ultraviolet irradiation. The parent strain contains a functional glucose dehydrogenase, glucose-6-phosphate dehydrogenase, diphosphofructoaldolase, and a 2-keto-3-deoxy-6-phosphogluconate aldolase, but is lacking in glucokinase, gluconokinase, 2-ketogluconokinase, and 6-phosphogluconate dehydrogenase. The enzymes present indicate partially functioning hexose diphosphate and Entner-Doudoroff pathways. The absence of kinases explains the inability of the strain to grow on glucose and an absence of 6-phosphogluconate dehydrogenase would indicate the absence of the complete pentose pathway. The mutant strain, M. polymorpha M, possesses, in addition to those enzymes produced by the wild type, both gluconokinase and 6-phosphogluconate dehydrogenase. The presence of the former explains the mutant's ability to grow on glucose, and the presence of the latter indicates a more complete pentose shunt. The supplemental energy obtained from partial glucose catabolism (to gluconic acid) may be obtained from a cytochrome-linked reaction of the glucose dehydrogenase.

Acinetobacter↗
PubMed1964

FURTHER OBSERVATIONS ON MIMA POLYMORPHA AND ACHROMOBACTER (BACTERIUM) ANITRATUM.

Further investigations on the morphology, biochemical reactions, and serological relationships of strains of Mima polymorpha and Achromobacter (Bacterium) anitratum are reported. The results seem to indicate such a close relationship that it may yet be necessary to reconsider the nomenclature of these organisms.

Achromobacter↗
PubMed1965

BACTERIUM ANITRATUM AND MIMA POLYMORPHA INFECTION IN UGANDA.

Eleven cases of infection with Bacterium anitratum and one with Mima polymorpha are described. Microscopically the organisms showed Gram-negative or Gram-variable diplococci with a tendency to form filaments. There appear to be a number of biochemical variants of B. anitratum. Serological cross-reactions with the genus Klebsiella was found. The antibiotic patterns are given and particular attention is drawn to the resistance of the organisms to chloramphenicol.

Abscess↗
PubMed1975

Corneal perforation and iris prolapse due to Mima polymorpha.

An 11-year-old girl had hyperacute conjunctivitis but was lost to follow-up until nine days later when she returned with a corneal perforation and iris prolapse. A smear at that time showed Gram-negative intracellular diplococci, but subsequent bacteriological study revealed the causative organism to be Mima polymorpha. This apparently is the first documented case of corneal perforation due to Mimeae, and emphasizes that Mimeae can be completely indistinguishable, clinically and on smear, from infection caused by Neisseria. Only a high index of suspicion and the proper bacterial cultures can prevent a possible tragic misdiagnosis.

Acinetobacter Infections↗
PubMed2003

Energy budgets in Charney-Hasegawa-Mima and surface quasigeostrophic turbulence.

We study energy transfer in unbounded Charney-Hasegawa-Mima and surface quasigeostrophic turbulence. The possible inverse-cascading quantities in these systems are, respectively, I identical with integral ( infinity )(0)k(-2)E(k) dk and J identical with integral ( infinity )(0)k(-1)E(k) dk, where E(k) is the kinetic energy spectrum. The supposed direct-cascading quantities for both surface quasigeostrophic and Navier-Stokes turbulence are shown to be bounded. We derive a constraint on E(k) for the surface quasigeostrophic system.

Journal Article↗
PubMed1976

In vitro and in vivo activities of minocycline and other antibiotics against Acinetobacter (Herellea-Mima).

Minocycline was the most active of six antibiotics tested against 65 clinical isolates of Acinetobacter calcoaceticus (syn.: Herellea, Mima) received from six medical centers. In the Bauer-Kirby disk susceptibility test, all isolates were rated susceptible to minocycline, gentamicin, and polymyxin; 25% were resistant to tetracycline. In agar dilution tests, minocycline was two to four times more potent than gentamicin or polymyxin and eight times more potent than tetracycline. Ampicillin and cephalexin were relatively ineffective. Against lethal infections produced by five strains of A. calcoaceticus in mice, minocycline was, in general, more active than gentamicin or polymyxin on a dosage basis and significantly more active on a blood-level basis. Minocycline was significantly more potent than tetracycline on both dosage and blood-level bases against tetracycline-sensitive and -resistant strains. In the last decade there has been an increase in the reported incidence of acinetobacters in a variety of infections. The cultures are susceptible to few antibiotics. Our data show that minocycline could offer an effective alternative to the more toxic drugs for the treatment of these infections. Susceptibility should be determined with minocycline disks.

Acinetobacter↗
PubMed1969

Identification of the Mima-Herellea group of organisms and selected members of the genus Neisseria.

To determine a rapid and reliable protocol for the differentiation of Mima polymorpha, M. polymorpha var. oxidans, Herellea, Bacterium antitratum, Neisseria gonorrheae, and other related members of the genus Neisseria, reference cultures were examined on a variety of microbiological media. The media were selected because of the typical morphological and biochemical characteristics exhibited by the test organisms and were those media which would be readily available in a microbiology facility. After compiling data obtained from 21,714 observations, an inclusive protocol is presented which has proven to be quite adequate for the identification of these particular gram-negative bacteria.

Acinetobacter↗
PubMed1972

Uptake and killing of Mima polymorpha and Herellea vaginicola by the reticuloendothelial system of neonatally thymectomized nonwasted mice.

Phagocytosis and killing of Mima polymorpha and Herellea vaginicola by the liver, lungs, spleen, and kidneys from neonatally thymectomized nonwasted mice and their sham-thymectomized litter mates were compared. The removal of M. polymorpha from blood by these organs, measured 2 and 4 hr after intravenous injection of bacteria, was not affected by thymectomy. Because significantly fewer viable organisms persisted in the liver, spleen, and kidneys, it is concluded that bacterial killing increased after thymectomy. Phagocytosis of M. polymorpha by peritoneal macrophages increased in thymectomized mice. Removal of H. vaginicola from the blood by the lungs was greater after thymectomy. Thymectomy did not affect the killing of H. vaginicola by the liver, spleen, lungs, or kidneys. Killing of H. vaginicola by the kidney was less than that by other organs, although this was not affected by thymectomy. Chronic reticuloendothelial stimulation associated with infection was not an adequate explanation for these findings because no wasting syndrome was encountered.

Acinetobacter↗
PubMed1978

Corneal perforation due to Helminthosporium and Mima polymorpha.

This apparently is the first reported case of corneal perforation due to a mixed infection of Helminthosporium species and Mima polymorpha. These 2 organisms separately rarely cause ocular infection and when present together could produce serious damage to the eye. In long-standing diseases of the cornea, mixed infection should be suspected when the infection fails to respond to conventional medical therapy. Thorough laboratory evaluation should be done. Selection of appropriate antibiotics should be based on clinical impression, initial Gram stain findings and final cultural results.

Acinetobacter Infections↗