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At least 19 recordsLinked to original sources

The prevalence of psoriasis in the Mongoloid race.

Statistics for psoriatic patients from the skin clinics of the Hong Kong Government and those from Sendai, Japan, are compared with statistics from five major cities in mainland China. These statistics were compiled since 1949, following the establishment of the People's Republic of China. Additional statistics from seven other surveys among the general population conducted in recent years (1974 to 1981), for a total of 670,000 persons examined, all showed a remarkably constant and uniformly low prevalence of psoriasis at around 0.3% in five of seven surveys. The overall statistics present the evidence of the prevalence of psoriasis to be well under 1% in the Mongoloid races of the Far East.

Adolescent↗

[A dental anthropological study of Chinese in Taiwan. I). Craniofacial morphology].

The cephalometric films were collected from 30 boys and 30 girls of 12 years of age, and from 36 males and 34 females of 18 years of age; all of whom were Chinese in Taiwan, all possessed acceptable occlusion to survey the craniofacial morphology and characteristics associated with dental anthropology. Data were analysed by the computer program at the Department of Orthodontics of Japan Tokyo Medical and Dental University. Data were compared with Japanese, North American Caucasians, Central and South American Indians from papers. It was concluded that: 1) Chinese in Taiwan were similar to Japanese, Central and South American Indians, in that; all possessed a shorter frontal cranial base and depth of face, and were completely different from North American Caucasians. The direction of growth showed counter-clockwise rotation in the four Mongoloid races; however, Caucasians showed straight--down growth. The four Mongoloid races had more frontal position of A,B point and more labial inclination of anterior tooth axis than Caucasians. 2) Chinese in Taiwan were similar to Japanese, but were different from Central and South American Indians, in having a flatter infraorbital outline, longer facial height, flattened mandibular plane angle and a more frontal position of chin. 3) Chinese in Taiwan were characteristically different from Japanese by having a smaller interincisal angle, lower frontal facial height, mandibular angle and mandibular plane angle. In summary, the results indicated that Chinese in Taiwan are characterized by having a wide but short face pattern, a retroposition of the mandible ramus, a more upright mandible angle and a prominent labial inclination of anterior tooth axis.

Adolescent↗

[Peculiarities of hypoacusis in citizens of the East Siberia].

Hearing disorders are characterized for citizens of the East Siberia belonging to Europeoid or Mongoloid race. Interpopulation features of hypoacusis of various genesis and effects of natural-geographic and ethnic factors on hypoacusis manifestations in native Mongoloid and migrant Europeoid Siberian population are shown.

Adolescent↗

Malignant lymphoepithelial lesions of the salivary glands with anaplastic carcinomatous change. Report of nine cases and review of literature.

Nine cases of malignant lymphoepithelial lesion with anaplastic carcinomatous change (MLEACC) of the salivary glands are presented. In addition to the cases previously reported in the literature, the total number of cases of MLELACC now amounts to 58, among which 39 cases were of the Mongoloid race with 30 Eskimos and 9 Chinese. Histologic findings are in accordance with Hilderman's original description, i.e., well demarcated cancer cell islands with the presence of occasional lumens found lying in a background of lymphoid stroma, and with lymphoid follicle formation and the presence of remnants of salivary ducts or even glands. Epimyoepithelial islands were found in some cases. Based on the above definitive histologic features and a better prognosis, this tumor is different from anaplastic carcinomas at other sites. These patients have a prolonged survival if there is early radical excision with or without irradiation immediately the diagnosis is made; or if there is early local excision whenever there is a tumor of the salivary gland and there is local excision of a recurrent tumor mass and excision of metastatic lymph nodes and distant metastatic nodules.

Adult↗

GAPO syndrome: report on the first case in Japan.

We studied a 3.5-year-old Japanese boy with growth retardation, alopecia, pseudoanodontia, and bilateral papilledema. He was born of nonconsanguineous parents, but his paternal grandparents were related. From his characteristic physical manifestations, we diagnosed him as the first known case of GAPO syndrome in Japan and perhaps in the Mongoloid race. Our case had prominent dilatation of scalp veins and an audible intracranial bruit. Cranial angiography documented a narrowing of the sigmoid sinuses, with no flow to either jugular vein. We discuss here the relationships between optic atrophy and intracranial vascular changes in this syndrome.

Abnormalities, Multiple↗

Compact bone changes in cold-exposed rats.

Rats exposed to cold stress show a reduction of relative cortical thickness in their long bones. The reaction resembles reduction of cortical thickness observed in Asiatic humans of the Mongoloid race, in whom many morphological features have been postulated to be cold-adaptive. However, until it can be established that the physiological processes underlying the experimental and phylogenetic condition are similar, no extrapolation can be attempted from the one to the other.

Acclimatization↗

[Genetically-induced variability of alcohol metabolism and its effect on drinking behavior and predisposition to alcoholism].

Alcoholism is one of the most challenging current health problems in the Western countries with far-reaching medical, social, and economic consequences. There are a series of factors that interact in predisposing or protecting an individual against alcoholism and alcohol-related disorders. This article surveys the state of our knowledge concerning the biochemical and genetic variations in alcohol metabolism and their implications in alcohol sensitivity, alcohol drinking habits, and alcoholism in different racial/ethnic groups. The major pathway for the degradation of ethanol is its oxidation to hydrogen and acetaldehyde--to which many of the toxic effects of ethanol can be attributed. Variations in alcohol and acetaldehyde metabolism via genetically determined polymorphisms in alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) seem to play an important role in individual and racial differences in acute and chronic reactions to alcohol, alcohol drinking habits, as well as vulnerability to organ damage after chronic alcohol abuse. Alcohol sensitivity and associated discomfort symptoms accompanying alcohol ingestion may be determinental for the significantly low incidence of alcoholism among the Japanese, Chinese and other Orientals of Mongoloid origin. An abnormal ALDH isozyme has been found to be widely prevalent among individuals of the Mongoloid race and is mainly responsible for the acute sensitivity to alcohol commonly observed in this race. Persons sensitive to alcohol by virtue of their genetically controlled ALDH isozyme deficiency may be discouraged from drinking large amounts of alcohol in their daily life due to the initial adverse reaction experienced after drinking alcohol. Indeed, a significantly low incidence of the mitochondrial ALDH isozyme deficiency has been observed in alcoholics as compared to psychiatric patients, drug dependents and healthy controls in Japan. How far any variation in ADH and/or ALDH activity among individuals of Caucasian origin will have similar effects has yet to be studied.

Alcohol Dehydrogenase↗

Systemic lupus erythematosus in North Indian Asians. A prospective analysis of clinical and immunological features.

One hundred and one patients with systemic lupus erythematosus (SLE) from North Indian stock are presented. The clinical manifestations, laboratory parameters, causes of death, and survival are compared and contrasted with the other major reported series. SLE of North Indian Asians has several features comparable to those reported from the West, but other features are more similar to the SLE seen in Mongoloid races.

Antibodies, Antinuclear↗

Human aldehyde dehydrogenases: their role in alcoholism.

This article surveys the state of our knowledge concerning the biochemical and genetic variations in aldehyde dehydrogenases (ALDHs) in humans and their role in alcohol sensitivity, alcohol drinking habits, and alcoholism. Variations in acetaldehyde metabolism via genetically determined polymorphisms in ALDH enzymes seem to play an important role in individual and racial differences in acute and chronic effects of alcohol drinking as well as towards vulnerability to organ damage after chronic alcohol abuse. Alcohol sensitivity and associated discomfort symptoms accompanying alcohol ingestion may be determinantal for the significantly low incidence of alcoholism among Japanese, Chinese and other Orientals of Mongoloid origin. An abnormal ALDH isozyme has been found to be widely prevalent among individuals of Mongoloid race, and is mainly responsible for the acute sensitivity to alcohol commonly observed in this race. Persons sensitive to alcohol by virtue of their genetically controlled ALDH isozyme deficiency may be discouraged from drinking large amounts of alcohol in their daily life due to the initial adverse reaction experienced after drinking alcohol, and thus are protected against alcoholism.

Alcohol Drinking↗

Genetic polymorphism revealed by 13 tetrameric and 2 pentameric STR loci in four Mongoloid tribal population.

The short tandem repeat allelic profiles at to 15 autosomal polymorphic loci were analyzed in four tribal populations of Mizoram (India). The analysis was performed on 354 unrelated healthy individuals belonging to Mongoloid races. All the samples were subjected to sex test (Amelogenin marker) besides the STR typing and in all instances; it has shown no deviation from expectation. The allele frequencies for all the analyzed loci in the studied populations are within expected range in comparison to the populations from same racial background. No significant deviation from the Hardy-Weinberg Equilibrium was observed for all the populations. In no cases the observed heterozygosity is less than that of expected values and it varied from 0.978 (Penta E) to as low as 0.425 (THO1). The discriminatory power and exclusion probability values for all the analyzed markers are significantly high and thus reveal high forensic significance. There is no evidence for association of alleles among the 15 studied loci. This allele frequency data will be useful for human identity testing in Mizo population.

Asian People↗

Twinning rates in Fiji.

The incidence of twins in Fiji has been investigated using birth registrations for the years 1976-81. The twinning rate for the indigenous Fijians is found to be 9.4 per 1000 live maternities, (based on 407 sets of twins), and for Indians, descendants of immigrants who began to arrive in Fiji in 1879, 6.2 per 1000 (based on 350 twins). After standardizing for maternal age, the difference between the two ethnic groups decreases slightly, but the Fijian rate remains almost 40% above that of the Indians. This difference is consistent over the 6 years of the study, is found for mothers of all age groups under 40 and at all levels of parity. An analysis of hospital records in Fiji produces higher twinning rates for both Fijians and Indians, but a similar difference is found between the two ethnic groups. Although the twinning rate for Fijians is lower than that reported for other Melanesian people, it is well above reliable rates found for Mongoloid races from whom the Fijian is descended. The sparse information on twinning rates among Polynesians suggests rates not dissimilar from Melanesians, so that no support for the hypothesis of low twinning rates in the Pacific is evident. The twinning rate for Indians in Fiji is lower than rates reported from the Indian subcontinent.

Adult↗

Polymorphism of aldehyde dehydrogenase and alcohol sensitivity.

The metabolism of acetaldehyde has received considerable attention in the past years owing to its acute and chronic toxic effects in humans. Aldehyde dehydrogenase (ALDH) catalyzes the oxidation of acetaldehyde in liver and other organs. Two major isozymes of hepatic ALDH (ALDH I or E2 and ALDH II or E1), which differ in their structural and functional properties, have been characterized in humans. The ALDH I with a low Km for acetaldehyde is predominantly of mitochondrial origin and ALDH II which has a relatively higher Km is of cytosolic origin. An inherited deficiency of ALDH I isozyme has been found among Japanese and Chinese which is primarily responsible for producing acute alcohol sensitivity symptoms (flushing response) after drinking mild doses of alcohol. Biochemical, immunochemical and molecular genetics data indicate a structural mutation in the ALDH I isozyme gene responsible for the loss in catalytic activity. Population genetic studies indicate a wide prevalence of this ALDH polymorphism among individuals of Mongoloid race. Flushing response to alcohol shows familial resemblances and preliminary family data from Japan, China and Korea hint to an autosomal codominant inheritance for ALDH I isozyme deficiency. The ALDH polymorphism is apparently responsible for the low incidence of alcoholism in Japanese, Chinese and Koreans. Alcohol-induced sensitivity due to ALDH isozyme deficiency may act as an inhibitory factor against excessive alcohol drinking thereby imparting a protection against alcoholism.

Alcohol Drinking↗

[Genetic and environmental characteristics in dento-craniofacial morphology--using materials from survey on Latin American Indians].

Most previous researches of hereditary characteristics of the craniofacial skeleton have used the twin-study method. In this study, dental anthropological materials were used to clarify genetic and environmental characteristics of the dento-craniofacial morphology. The sample consisted of four groups including Mexican Indians (N = 71), Peruvian Indians (N = 41) and their ancient ancestors: skulls of Mexican Indians (N = 33) and Peruvian Indians (N = 34). These groups shared the common origin of the Mongoloid race. Morphological similarity and difference among these groups were examined by principal component analysis and Student t-test using the dento-craniofacial data based on roentgenographic cephalograms and dental casts. The morphological similarity means the genetic characteristics which maintained during time differences between ancient and present times and throughout regional differences between Mexico and Peru. The morphological difference means the environmental characteristics which produced during the time differences and throughout the regional differences. Results were as follows: (1) The genetic morphological characteristics were found predominantly in the anterior cranial base, the dental arch form and to a certain extent in the basal portion of the mandible and the vertical dimension of the naso-maxillary complex. (2) The environmental characteristics were found predominantly in the muscular portion of the mandible, the alveolar portions of the maxilla and the mandible, the length of the dental arch and to a certain extent in the antero-posterior dimension of the maxilla.

Adult↗

Genetic polymorphism of CYP1A1 and CYP2D6 in the Tundra Nentsi population of Siberia.

The purpose of this study was to establish the frequencies of CYP1A1 and CYP2D6 polymorphic genotypes in the Tundra Nentsi population, which is a small indigenous northern people living in Siberia and belonging to the Northern Mongoloid race. The frequencies of Ile/Ile, Ile/Val, and Val/Val genotypes in the Tundra Nentsi population, as determined by means of the allele-specific PCR, were 50.8%, 39.2%, and 10%, respectively. Thus, the Val allele frequency in Tundra Nentsi appeared to be as high (29.5%) as in the Japanese population (25%) reported elsewhere. Those frequencies in the reference group of Siberian Caucasians were in good agreement with the data reported elsewhere for other Caucasians, although the Val allele frequency observed in Siberia inhabitants (5.7%) was somewhat higher than those frequencies obtained for other Caucasian populations. By means of PCR followed by specific-site digestion with MvaI endonuclease, we analysed the frequencies of CYP2D6B allele in the Tundra Nentsi population. The frequencies of 2D6wt/2D6wt and 2D6wt/B in the group of 120 Nentsi were 84.2% and 15.8%, respectively, with no subject possessing the 2D6B/2D6B genotype. The group of Siberian Caucasians represented those frequencies as 67.7%, 27.1%, and 5.2%, respectively. In total, the frequency of CYP2D6B allele in the Tundra Nentsi population was half that in Caucasians (8.3% vs. 19%). Taken together, our data indicate that the frequencies of CYP2D6B and Val allele of CYP1A1 in Tundra Nentsi population are different from those obtained for Caucasians. We also found similarities in the CYP1A1 mutation frequencies in the Tundra Nentsi and Japanese populations.

Adult↗