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At least 19 recordsLinked to original sources
PubMed1994

[Pathogenesis of congenital hydrocephalus: role of transplacental myxovirus infection].

Several pediatric cases of hydrocephalus after mumps virus infection, have been reported. These cases are thought to be caused by ependymitis due to mumps virus infection. Clinical cases of congenital hydrocephalus possibly caused by intrauterine mumps virus infection are also accumulating. However, it has not yet been made clear whether mumps virus can pass through the human placenta and cause hydrocephalus. Our experimental studies demonstrated that mumps and parainfluenza virus type 3 could induce hydrocephalus by destructive ependymal infection in suckling hamsters, when they were inoculated intracerebrally or intraperitoneally. However, the transplacental infection of these viruses was extremely rare. These results show that myxoviruses such as mumps and parainfluenza virus may have a strong affinity to ependymal cells, and then they cause resultant ependymal destruction. Therefore, when the placenta is impaired so severely that these viruses are able to pass through the placental barrier, maternal infection would cause the hydrocephalus to the infant.

Animals↗
PubMed1969

Effect of myxovirus infection on synthesis of cellular ribonucleic acid.

Ribonucleic acid (RNA) synthesis of chick embryo fibroblasts was inhibited by two members of the myxovirus group, Newcastle disease virus (NDV) and fowl plague virus. It was also found that cellular deoxyribonucleic acid-dependent RNA polymerase was inhibited by a cytoplasmic factor induced by NDV infection.

Animals↗
PubMedDate not supplied

[Abortive myxovirus infection of Ehrlich ascites carcinoma cells. Analysis of virus-specific structures in the ascitic fluid].

In the course of classical fowl plague virus reproduction in Ehrlich ascites carcinoma cells both hemagglutinins and S-antigen accumulate and titers of the infectious activity increase. However virus reproduction does not terminate in formation of virus, and subviral structures are found in the liquid fraction of the infected cells. Analysis of these structures has shown them to have a sedimentation coefficient of 350-370S and buovant density 1.29 g/ml. The rapidly sedimenting structure has complement-fixing hemagglutinating activity but bow infectivity.

Amino Acids↗