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Mainstreaming of clinical genetic testing: A conceptual framework.

PURPOSE: Demand for genetic testing is increasing across medicine, whereas the genetics workforce remains stable. In response, mainstreaming models are being introduced, in which nongeneticist clinicians are increasingly involved in the genetic testing pathway. Because a standardized approach would facilitate evaluation and optimal patient care, a unified framework is warranted. METHODS: Through a focus group with clinical genetics experts, a conceptual framework for the mainstreaming of clinical genetic testing is proposed. Through a consensus process, experts elucidated the steps in the diagnostic care pathway and defined a set of variables that influence which mainstreaming model is best suited to specific patient care scenarios. RESULTS: A total of 35 individuals representing 20 distinct clinical genetics services and all Canadian provinces participated in the development of the framework. The framework describes 4 generalizable mainstreaming models of care, each with varying levels of involvement of the clinical genetics service in the diagnostic care pathway. CONCLUSION: This framework will help guide clinical teams in the design and evaluation of mainstreaming efforts. It is critical that these programs are evaluated and shared in a standardized way so that we can implement strategies that allow optimal utilization of genetics resources and improve patient care.

Humans

The work of specialist nurses in the mainstreaming of germline genomic testing in cancer: an investigation.

BACKGROUND: Specialist nurses are increasingly working in the mainstreaming of germline genomic testing in cancer. AIMS: The study aimed to investigate the work of specialist nurses in the mainstreaming of germline genomic testing in cancer, with a focus on Lynch syndrome, and to consider the future of genomics in nursing. METHODS: Semi-structured interviews were conducted with a purposive sample of 12 specialist nurses and three genetic counsellors, and thematic analysis was carried out. FINDINGS: Prominent themes arising from the data were: the capability and capacity of specialty-based clinical nurse specialists, for whom genomics is an added part of their wider role, to deliver genomic testing; and whether these specialty-based nurses or specialist genomic nurses, who work only in genomics, are best placed to deliver genomic testing. CONCLUSION: When planning service provision in the mainstreaming of genetic testing, the capacity and capability of specialty-based clinical nurse specialists should be considered alongside the possible need for specialist genomic nurses.

Humans

Mainstreaming psychiatry: some personal commentary.

The psychiatric education establishment is depicted as zealously searching for a set of educational principles that will allow maximum bandwagonry, maximum fundability. "Medical mainstream" is the current catch phrase selected for discussion. The contention of the author is that--instead-sound bio-social principles, easily available from child psychiatry as a field, would provide a dynamic substructure that would not be voguish and evanescent. Far from pursuing the medical mainstream, psychiatry might be more secure as an academic discipline were it to adopt an evangelical, illuminating attitude toward other medical specialties. In short, the proposal is made that general psychiatry and its fellow medical specialities ought to be brought into the child psychiatry mainstream. What child psychiatry could give to medicine and to general psychiatry is considered under these headings: a developmental perspective, a behavioral science sophistication, a medical foundation and lifestyle ("Aesculapian authority"), a humanistic attitude, and a stance of patient advocacy.

Attitude of Health Personnel

Reentry: a study of the movement of young drug users toward mainstream society.

In the middle 1960s hundreds of thousands of young people dramatically left American mainstream society to join the hippie movement. Almost ten years after the height of the hippie phenomenon, there has been little longitudinal investigation of the predictions by social scientists that these young people would be lost from future mainstream involvement. In the late 1960s, through a study of young drug users in the Haight-Ashbury neighborhood of San Francisco, my colleagues and I began to assess the degree of movement taken by hippie drug users toward mainstream society. This research focused on the differential outcome of three groups of young drug users, approximately two and a half years after they were initially studied.

Adult

Beyond the mainstream: the special needs of the chronic child patient.

Born of civil rights legislation and promoted by a desire for simple, rapid means of modifying behavior, Public Law 90-142 represents an effort at normalizing behaviorally disturbed children through "mainstreaming." This paper argues that a simplistic insistence on equality through mainstreaming violates the rights and needs of some behaviorally disturbed children to be different.

Adolescent

Educational mainstreaming of physically handicapped children.

The therapeutic and educational needs of 31 children who, after attending a private pre-school for the physically handicapped, were mainstrained in public schools are described in this paper. Their adjustment was followed for one to three years. Information was gathered through questionnaires and interviews with parents, children, and classroom teachers on how successful and to what extent the children had been mainstreamed, as well as what physical, academic, and social problems were encountered. Patterns and trends of relative educational abilities and disabilities of children with spina bifida and cerebral palsy are discussed in view of the literature and the problems encountered by this population. Questions that teachers frequently asked of health professionals who are experienced in dealing with the effects of handicapping conditions as well as a procedure for providing this information are also discussed. Successful mainstreaming depends on cooperative work and mutual advocacy among health professionals, parents, and educational personnel.

Adaptation, Psychological

Day treatment as an aid to mainstreaming troubled children.

Problem children who are diverted from public school programming into a private psychoeducational day facility in a community mental health center are followed up in a 10-year study to determine the rate of return to regular classes. The evidence points to a successful reintegration into public schools for the great majority of students. A philosophy for mainstreaming which supports the need for proper preparation of children for public school reentry is basic to effective management.

Adolescent

A look at mainstreaming in light of children's attitudes toward the handicapped.

Mainstreaming is a legislative reality, yet there is still a question as to whether non-handicapped students are prepared for it. In the present study 131 grade school students were each asked to select from the Personal Attribute Inventory for Children 15 adjectives which best fit three groups of handicapped children as well as normal children. The groups were described in a hierarchical fashion: "normal children" were rated most favorably, then "physically handicapped children," "learning disabled children," and "emotionally disturbed children.".

Adolescent

Moving the treatment of alcoholism into the medical mainstream.

This demonstration program for the treatment of alcoholism is based on the premise that alcoholism is a disease and that the primary care physician should play the central role in the overall management of alcoholism. The context of the Health Maintenance Organization (HMO) encourages the physician to assume responsibility for the care of the alcoholic and serves as the appropriate setting for the coordination of all modalities required.

Alcoholism

Inversion of Fahraeus effect and effect of mainstream flow on capillary hematocrit.

The well known Fahraeus effect (1929) states that if whole blood is allowed to flow from a large reservoir into a small circular cylindrical tube, the hematocrit in the tube is smaller than that in the reservoir, and the smaller the tube, the smaller will be the tube hematocrit. This is interpreted as a feature of particulate flow. We find that this relationship is not monotonic in a model experiment in which gelatin particles (circular disks) are suspended in a silicone fluid to simulate blood. When the diameter of the underformed cell is equal to or greater than the tube diameter, the volume fraction of the cells in the tubes increases to a value equal to or greater than that in the reservoir. Thus the Fahraeus effect has a point of inversion. Additional experiments show that the hematocrit in the tube could be greatly influenced by the flow condition outside the entrance of the tube. If the tube is perpendicular to the main direction of flow in the reservoir (as is the case of Barbee and Cokelet's experiment, or in most arteriole-capillary junctions), the velocity gradient and the velocity of flow in the reservoir just outside the entrance to the tube affects the hematocrit in the tube.

Blood Flow Velocity

The psychiatrist: in the mainstream or on the banks of medicine?

The author discusses psychiatry's historical estrangement from general medicine, beginning with its isolation in mental hospitals, aggravated by a deterioration in medical school teaching of clinical psychiatry and by limited psychiatric training programs, and further alienated by much of psychosomatic theory and practice. He sees hope for reconciliation, however, in the recent progress of psychopharmacology and liaison psychiatry within the general hospital.

Education, Medical, Continuing