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[The ontogenesis of the manubrium sterni in Tupaia belangeri].

The morphogenesis of the manubrium sterni was studied in a series of dated embryos of Tupaia belangeri. In addition to the sternal bands, the "paired suprasternal Anlage" takes part in the shaping of the manubrium sterni as reported by Klima (1968) for other mammals. It forms skeletal elements that mediate between the clavicle and the manubrium: the sternocalvicular ligament and the paired prominence on the dorsal surface of the manubrium, which underlies the clavicles. The paired prominence corresponds to the praeclavium present in some therians. Very probably, the discus articularis of the sternoclavicular articulation of some primates can be attributed to the suprasternal Anlage. There was, however, no indication that the ossa suprasternalia of primates develop from the suprasternal Anlagen: In Tupaia these Anlagen do not form the cranial part of the manubrium. Klima's "unpaired Anlage" develops differently in Tupaia than in other therians. It consists of connective tissue and is not integrated into the manubrium. It presents an insertion surface for the M. pectoralis major, which shifts its origin onto the manubrium, after the sternal bands have fused. The homology of the "unpaired Anlage" and the "pars chondralis interclaviculae" is doubtful.

Animals

Effect of resection of the sternum and manubrium in conjunction with muscle transposition on pulmonary function.

We recorded the changes in pulmonary function that occurred after removal of the sternum and manubrium and repair by pectoralis major muscle transposition in six patients. Of these patients, three had osteomyelitis of the manubrium and sternum, two had osteosarcoma of the sternum, and one had osteomyelitis and radionecrosis of the manubrium and sternum. Body plethysmography and the rebreathing, hypercapnic ventilatory response test with inductive plethysmographic recordings of chest-wall motion were performed preoperatively and postoperatively. Preoperatively, four of the six patients had evidence of mild to moderate chest-wall restriction. Pulmonary function was normal in the other two patients. Postoperatively, total lung capacity was unchanged but the vital capacity decreased 11.5% in the overall group. Static compliance, retractive force, and the steady-state diffusing capacity for carbon monoxide decreased modestly but significantly postoperatively. The expiratory flow rates and maximal voluntary ventilation remained unchanged. Preoperatively, the slope of the hypercapnic ventilatory response was less than that predicted. Postoperatively, the slope did not change. In three patients, however, increased dependence on the abdomen for breathing suggested a dynamic restriction of rib-cage motion. On the basis of our findings, we conclude that surgical removal of the sternum and manubrium in conjunction with muscle flap repair is a well-tolerated procedure. Any postoperative changes in pulmonary function are minor.

Adolescent

On the degree of rigidity of the manubrium in a finite-element model of the cat eardrum.

It has always been assumed that the manubrium is in effect perfectly rigid. In this paper, a more realistic model of the manubrium is incorporated into an existing finite-element model of the cat eardrum. The manubrial thickness is based on a three-dimensional reconstruction from serial histological sections. After a review of the literature, a value of 2 x 10(11) dyn cm-2 is adopted for the Young's modulus of the bone. The mode of vibration of the model is investigated for different manubrial-thickness values and it is found that a significant degree of manubrial bending occurs in the model for realistic values of manubrial thickness. As a result of the bending, the frequency response at the umbo at high frequencies displays much higher amplitudes and larger phase lags than when the manubrium is rigid. The bending will also affect the displacements transmitted to the ossicular load, and introduce significant errors into estimates of such displacements based on measurements of umbo displacement even at frequencies as low as a few kHz. Recent measurements of manubrium vibrations in the cat ear provide experimental evidence of bending.

Animals

Sclerotic changes of the manubrium sterni.

Six females with nearly identical sclerotic and hyperostotic changes of the manubrium sterni are reported. Malignancies, bacterial inflammatory processes, and Paget disease, which were first suspected, could be excluded. The youngest patients also had sclerotic changes of other bones, including the lumbar spine, the pubic bone, and the clavicle, and may be classified as having "chronic recurrent multifocal osteomyelitis" (CRMO). The two oldest patients had ossification of the costoclavicular ligament(s) and may be classified as having "inter-sterno-costo-clavicular ossification" (ISCCO). One had only hyperostotic and sclerotic changes as seen in "sterno-costo-clavicular hyperostosis" (SCCH). The pathogenesis of these uncommon diseases is unknown, but they are all frequently associated with pustulosis palmo-plantaris and have similar clinical courses and laboratory abnormalities. None of the present patients had HLA-B27. The similarity of the radiological abnormalities of the manubrium sterni suggests that the diseases themselves may be similar, but with different courses depending on age, CRMO being present in children and young adults and ISCCO or SCCH in older adults.

Adult

Clinical use of the olecranon-manubrium percussion sign in shoulder trauma.

We conducted a study to assess the efficacy of the use of osteophony in the evaluation of shoulder trauma. Evaluation of the shoulder includes the physical examination and often a radiographic series. We studied the usefulness of the olecranon-manubrium percussion (OMP) test, a physical diagnostic procedure performed in shoulder trauma. The bell of the stethoscope is placed over the manubrium, both elbows are flexed at 90 degrees, and the olecranon is percussed. In the normal examination with no disruption of bony conduction, both sides should produce a crisp equal sound. In the event of a dislocation or fracture with disruption of bony conduction, the affected side should be duller in pitch and intensity. We evaluated the utilization of the OMP test to assess its accuracy when used as a screening test for radiographs in conjunction with the physical examination and radiographic examination. Ninety-six patients were prospectively evaluated by the OMP test and also received radiographs. In those patients who had radiographic abnormalities, 40 of 47 (85.1%) had an abnormal OMP sign. In those patients without radiographic abnormalities, none had an abnormal OMP sign. In assessing anterior shoulder dislocations, 11 of 13 (84.6%) had an abnormal OMP sign (P less than .02). After relocation, 100% had a normal OMP sign. Of those with clavicular fractures, nine of nine (100%) had abnormal OMP signs (P less than .005). Of those with a fracture of the humerus, 16 of 20 (80%) revealed an abnormal OMP test (P less than .01). The test was not significant in assessing acromio-clavicular joint abnormalities.(ABSTRACT TRUNCATED AT 250 WORDS)

Emergencies

[Reconstruction of the thoracic wall in neoplasms of the manubrium of sternum].

The case of a voluminous neoplasia originating at the manubrium sterni is described. Given the rapid growth of the mass and its dimensions, the mass was removed surgically together with the manubrium sterni and the sternal extremity of the clavicle and of the first two ribs. The defect in the anterior wall of the thorax was filled by a net of prolene partially covered with the mobilised pectoral muscles. Functional and aesthetic results were very good. Assisted respiration was not necessary in the immediate postoperative period and the net remained stable and firmly in place during respiration. One month after the operation, respiratory function tests were on a par with those done prior to the operation. The positioning of prolene nets for the reconstruction of the thoracic wall is an extremely effective technique which makes it possible to preserve satisfactory respiratory mechanics even after the removal of extensive portions of the thoracic wall.

Female

Resection of the manubrium.

Direct exposure of the superior mediastinum is essential when resecting subglottic tumours of the larynx, neoplasms of the cervical trachea or cervical oesophagus. This facilitates low resection of the trachea and clearance of the paratracheal nodes. This may best be carried out by removal of most of the manubrium sterni and both sternoclavicular joints and this operation has been performed in 22 patients with minimal morbidity or long term disability.

Esophageal Neoplasms

Radiology of postnatal skeletal development. II. The manubrium and sternum.

Thirty-six manubriosternal composites from skeletally immature cadavers were examined morphologically and radiographically. Sternebral ossification followed certain patterns. The manubrium (first sternebra) usually had one primary ossification center and one or two smaller centers. These usually were caudad to the major center (longitudinally bifid). The second sternebra invariably had only one ossification center. The third and fourth sternebrae had latitudinal (right-left) bifid ossification centers, undoubtedly a result of the original formation of the sternum from two longitudinal mesenchymal anlagen. Occasionally the fourth sternebra exhibited longitudinally bifid ossification. The usual pattern was ossification of four sternebrae, although a fifth was intermittently present. The xiphisternum (not a true sternebra) was infrequently ossified.

Adolescent

Sclerosis and hyperostosis of the manubrium sterni.

Seven females and one male with almost identical sclerotic and hyperostotic changes of the manubrium sterni are reported. The clinical course was prolonged and characterized by intermittent periods of exacerbation followed by improvement. Malignancies, bacterial inflammatory processes, and Paget disease, which were first suspected, could be excluded. Pustulosis-palmoplantaris was present in four patients and one had psoriasis vulgaris. None of the patients had sacroiliitis or peripheral joint changes, but the three youngest patients had sclerotic changes of other bones, including the lumbar spine, the pubic bone, and the clavicle. This may indicate that this is an adult disease analogous to "chronic recurrent multifocal osteomyelitis", a disease mainly present in children and adolescents.

Adult

Chondrosarcoma of the manubrium. Resection and reconstruction with pectoralis major muscle.

Chondrosarcomas of the sternum are best treated by resection with tumor-free margins. Reconstruction of the manubrium and superior aspect of the sternum is one of the most difficult challenges for the reconstructive surgeon. In the past, most of the structural stability following resection of this area has depended on the formation of dense fibrous tissue and scar. We presented a case of reconstruction of the bony defect with autogenous bone grafting in conjunction with transposition of the pectoralis major muscle for increased protection and stability of the chest wall as well as for nourishment for the bone graft.

Chondrosarcoma

Heterodyne interferometer measurements of the frequency response of the manubrium tip in cat.

A heterodyne interferometer proved to be a very accurate tool to measure amplitude and phase of the malleus response during acoustical stimulation. It was shown that to obtain equal accuracy in the acoustical pressure measurements, pressure response must be remeasured at short time intervals. At frequencies above 4 kHz various gross resonances are apparent on the frequency response curves. The resonances are, depending on the animal, more or less pronounced. As a result of the improved accuracy changes of the malleus vibration response with time could clearly be discriminated. These changes can be related to shifts in frequency of the position of these resonances. Comparison of experimental frequency response and lumped parameter model predictions from literature shows that these resonances are not present in the model responses.

Acoustics