PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “Markey Report”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 19 recordsLinked to original sources

A limited bibliography of the Federal Government-funded human radiation experiments.

From the early 1940's thousands of U.S. citizens have been the subjects of federally supported scientific experiments that involved the administration of ionizing radiation or radioactive substances. Recently, many questions have been raised regarding the nature, scientific value, and ethics of these experiments. Although the results of many of the early human experiments involving radiation have been crucial to the establishment of nuclear medicine, radiation therapy, and radiological protection standards, the underlying ethical basis for a small number of these studies is being questioned. A thorough analysis of these studies and their ethical basis is beyond the scope of this article. Rather, in order to quickly provide the health physics community with some of the available resources in the open literature, a list of bibliographic citations of the 47 studies primarily funded by the Atomic Energy Commission (AEC) and other predecessors of the Department of Energy is presented and briefly summarized. A classification scheme for the human radiation experiments is also developed.

Bioethics↗

Effect of frequency of horizontal linear oscillation on motion sickness and somatogravic illusion.

BACKGROUND: Low frequency linear (translational) oscillation is an important stimulus in provoking motion sickness in a variety of modes of transport. HYPOTHESIS: Lower frequencies of horizontal linear oscillation would be more nauseogenic. The somatogravic illusion (SGI) would be affected by frequency. METHODS: Subjects (n = 12) were exposed to horizontal sinusoidal motion (3.6 m.s-2 peak) at three different frequencies (0.205 Hz, 0.350 Hz, 0.500 Hz) at one week intervals, with order randomized between subjects. Subjects were seated in the upright position, with motion through the X head body axis. RESULTS: The mean (+/- S.D.) motion exposure time required to produce moderate nausea decreased significantly (p < 0.01) towards the lower frequency: 24.4 +/- 19.3 min. at 0.500 Hz, 12.0 +/- 9.5 min. at 0.350 Hz, 7.8 +/- 6.2 min. at 0.205 Hz. The linear fit of time (t) to nausea with frequency was -7.4 dB/octave. This was equivalent to a -3.7 dB/octave decrease of nauseogenic potential with increasing frequency, if t1/2 were to be used as in the standard "motion dose" models. The SGI was reported by 5/12 subjects (mean illusory tilting angles 16.2 degrees forward, 14.3 degrees back) but there was no relationship between SGI and motion frequency or motion sickness. CONCLUSIONS: Horizontal motion with subjects seated upright was more nauseogenic than would be predicted by mathematical models based on vertical oscillation, and the relationship of frequency to nauseogenicity for horizontal motion was significantly less steep than that previously reported for vertical motion.

Adult↗

Stable E rosette-forming lymphocytes in the peripheral blood in non-Hodgkin's lymphoma.

The peripheral blood of 49 patients with non-Hodgkin's lymphoma and the same number of normal controls was examined for the presence of lymphocytes forming rosettes with sheep erythrocytes at 37 degrees C (stable E rosettes). Nineteen lymphoma patients but only five normal controls showed increased absolute levels. (P less than 0.01). There was no correlation between the occurrence of increased Stable E Rosette levels and the histological type of lymphoma but there appears to be a positive relationship with the presence of clinical stage III-IV disease at presentation (P = 0.011). It is suggested that stable E rosettes represent an immunological response to residual lymphoma in our patients. A longitudinal study in one patient is reported in detail to demonstrate the occurrence of fluctuations in stable E rosette levels coinciding with clinical changes.

Aged↗

Bone marrow necrosis.

Bone marrow necrosis is most frequently diagnosed at postmortem examination. Antemortem diagnosis is still uncommon. In a recent review of world literature, we have found 133 cases of bone marrow necrosis diagnosed during life. It has been observed during the course of a wide variety of diseases, most commonly in association with acute and chronic leukemia, carcinoma, malignant lymphoma, infections, and sickle cell disease. We report two intravitally diagnosed cases of bone marrow necrosis occurring in two patients with high-grade B-cell lymphoproliferative disease. These cases are unusual in that both patients had a triad of bone marrow necrosis, high-grade B-cell lymphoproliferative disease, and hypercalcemia. Despite chemotherapy, both cases ultimately proved fatal, with progressive involvement of the central nervous system.

Adolescent↗

Hand and forearm infections caused by Aeromonas hydrophila.

This is a report of two cases of hand and forearm infections caused by Aeromonas hydrophila. This organism is resistant to penicillin and most cephalosporins and is found in most freshwater environments. It is recommended that broad-spectrum coverage such as a combination of cephalosporin and aminoglycoside antibiotic be used.

Adolescent↗

Fatal carbon monoxide poisoning after the detonation of explosives in an underground mine: a case report.

An unusual death caused by carbon monoxide poisoning after the detonation of explosives in an underground mine was investigated by the Office of the Medical Investigator of the State of New Mexico. The 50-year-old miner had 18 years of mining experience but no documented safety training. He collapsed approximately 20 minutes after entering the mine and working at the bottom of the single vertical shaft. The tight confines of the mine shaft hindered rescue personnel from reaching him, and the body was not recovered until 2 days later. The autopsy showed severe coronary artery atherosclerosis with remote and resolving myocardial microinfarcts, as well as the characteristic pink lividity of carbon monoxide poisoning, which was confirmed by laboratory analysis. Detailed investigation of the scene revealed no sources of carbon monoxide other than the explosives. The case represents an uncommon cause of death in mining that may have been avoided through the use of proper safety procedures, and illustrates the importance of recognizing the many sources of carbon monoxide.

Carbon Monoxide Poisoning↗

Successful long-term stenting of an atypical descending aortic coarctation.

Stenotic lesions of the descending aorta are rare causes of coarctation of the aorta. The majority of cases of atypical coarctation are thought to be caused by Takayasu's arteritis. This report describes an atypical coarctation of the descending aorta treated with angioplasty and stent placement. Patency of the stent and control of the hypertension at 2 and a half years suggest that endovascular treatment of atypical coarctation may be successful with the use of mechanical stents and may be an alternative to surgical correction.

Adult↗

DBParser: web-based software for shotgun proteomic data analyses.

We describe a web-based program called 'DBParser' for rapidly culling, merging, and comparing sequence search engine results from multiple LC-MS/MS peptide analyses. DBParser employs the principle of parsimony to consolidate redundant protein assignments and derive the most concise set of proteins consistent with all of the assigned peptide sequences observed in an experiment or series of experiments. The resulting reports summarize peptide and protein identifications from multidimensional experiments that may contain a single data set or combine data from a group of data sets, all related to a single analytical sample. Additionally, the results of multiple experiments, each of which may contain several data sets, can be compared in reports that identify features that are common or different. DBParser actively links to the primary mass spectral data and to public online databases such as NCBI, GO, and Swiss-Prot in order to structure contextually specific reports for biologists and biochemists.

Amino Acid Sequence↗

Idiopathic pure red cell aplasia: first report on CD8 positive lymphocytosis in bone marrow biopsy sections.

There is no information in the literature regarding the lymphocyte content or type in bone marrow biopsies from patients with "idiopathic" pure red cell aplasia (PRCA). This report describes the bone marrow biopsy sections of a patient with PRCA. A diffuse CD3 positive (CD8 positive, granzyme B negative) lymphocytosis of approximately 1500/mm3 was revealed by immunohistochemical staining. The extent of the T cell increase was not evident from morphological examination of the bone marrow aspirate or biopsy, from flow cytometric analysis of the aspirate, or from the peripheral blood lymphocyte count. Therefore, immunohistochemical analysis should be performed routinely in this rare disease and the data acquired may help to inform the choice of treatment.

Adult↗