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Relationship of chronic ethmoidal sinusitis, maxillary sinusitis, and ostial permeability controlled by sinusomanometry: statistical study.

Three hundred sixty-seven successive patients suffering from chronic maxillary sinusitis (CMS) were thoroughly examined by means of maxillary sinusoscopy, a CT scan of the facial sinuses, and sinusomanometry (SMM). Ninety-eight cases of unilateral CMS, 269 cases of bilateral CMS, and 444 chronic ethmoidal sinusitis (CES) cases were evaluated. According to SMM, the maxillary ostia were divided into two groups: 1. maxillary ostium patency (MOP) group and 2. the maxillary ostium nonpatency (MONP) group. The unilateral and bilateral pathologies were separately analyzed so as to minimize the effects of general or systemic causes on the results. MONP is, in both bilateral and unilateral groups, significantly linked with the presence of ethmoidal sinusitis (P < 10(-6); P = .026), while the correlation between MOP and the ethmoid status does not appear to be significant in either group. Thus, there seems to be a close relationship between CES and maxillary ostial dyspermeability in cases of CMS.

Belgium

Maxillary sinus hypoplasia masquerading as chronic sinusitis.

Maxillary sinus hypoplasia is a common condition that may be misdiagnosed as chronic sinusitis. Although hypoplasia can usually be seen on conventional sinus films, computed tomography may be necessary, as in the cases described by the authors in this article.

Adult

[Clinical, radiographic and endoscopic evaluation of the maxillary sinus after maxillary osteotomy].

36 osteotomies performed between 1982 and 1988 involved opening the maxilla. Postoperative clinical, radiographic and endoscopic follow-up revealed that the majority of the patients had no or only minor pathological alterations of the maxillary sinuses. Sinuscopy showed only 2 maxillary sinuses to have more extensive mucosal alterations. Remarkably, it was particularly the osteosynthesis material protruding into the maxillary sinus that was surrounded by or overgrown with non-irritated mucosa.

Endoscopy

Cancers of the maxillary sinus.

Maxillary sinus cancers are rare as compared with cancers of other sites. Because the onset is insidious, they are at an advanced stage at diagnosis and therefore present a therapeutic challenge for local control. Traditionally, treatment has been surgery or irradiation, or a combination of the two. Local control and survival, however, remains poor. Numerous chemotherapeutic agents have shown activity against squamous cell cancers of the head and neck. In several studies the use of either neoadjuvant or concurrent chemotherapy has improved local control and survival when compared with historical controls. Randomized studies are needed to confirm the benefit of chemotherapy over the standard forms of surgical and radiation therapy.

Adenocarcinoma

Surgical treatment of chronic hyperplastic sinusitis and maxillary sinus empyema of oral/dental origin.

Twelve patients with maxillary hyperplastic sinusitis or maxillary sinus empyema of oral/dental etiology have been treated according to a modified surgical technique. The treatment was initiated by several oro-nasal irrigations and drainage facilitated by an intact semilunar hiatus. This was followed by a surgical procedure including conservative curettage of inflamed sinus mucosa, adequate closure of the oro/antral communication, with establishment of a postoperative oral antrostomy. This antrostomy, through the canine fossa, was established by a vacuum drain, enabling continuous postoperative irrigation and aspiration. The rationale for this technique is discussed. A total of 12 patients operated according to this technique are described. Complete clinical and radiographic healing in all patients was observed over a postoperative period ranging from 6-12 months.

Adult

Measurement of velocity of air flow in the sinus maxillaris.

Anemometry with the hot wire and hot film technique previously described, enables the rhinologist to record slow and rapidly changing air flow in the maxillary sinus. The advantages and disadvantages of this method are considered. Anemometry together with manometry may be designated sinumetry and used as a diagnostic procedure following sinuscopy in chronic maxillary sinus disease. The value of the function from velocity of time allows the estimation of flow-volume in the sinus. Furthermore, the method is useful to evaluate the optimal therapy to restore ventilation in the case of an obstructed ostium demonstrated before and after surgical opening in the inferior meatus.

Humans

Penetration of erythromycin stearate into maxillary sinus mucosa and secretion in chronic maxillary sinusitis.

The penetration of oral erythromycin stearate (Abboticin), administered in a dosage of 500 mg three times a day, into the maxillary sinus mucosa and secretion was studied in 15 patients (22 sinuses) operated on for chronic maxillary sinusitis. The average concentration in serum was 2.3 microgram/ml, 1.2 microgram/ml in secretion, and 1.8 microgram/ml in mucosa. These concentrations are highly effective against diplococci and most aerobic and anaerobic streptococci (MIC value 0.06 microgram/ml) but not against Haemophilus influenzae (MIC value for 80% of 2 microgram/ml).

Administration, Oral

[Tomography of the maxillary sinus].

The maxillary sinuses were studied roentgenographically and tomographically in 108 patients (with intact sinuses) and in 16 anatomical preparations of the cranium. It has been established that the main features of the laminar picture of the maxillary sinuses can be determined by two main properties of tomography as a method: the possibility to lead the portions of the sinus osseous walls of greater-length as compared with conventional roentgenography out to the edge-forming zone due to oblique course of the ray beam, and vise versa, disappearance of outlines of these walls in those sections where they are considerably inclined in relation to the roentgen film plane. A description of the laminar roentgen-anatomical picture of the maxillary sinuses in naso-frontal, nasomental and lateral projections is presented. It is stresses that in each of these projections several main types of the laminar picture of the maxillary sinuses can be detected, characterizing different depth of sections.

Humans

[The effect of various antibiotics on the mixed flora of the maxillary sinus in sinusitis(author's transl)].

The effect of four frequently used antibiotics on the germs of the sinus maxillaris was studied. For this purpose germs of the sinus max. rinsing fluid, got from 127 patients, were cultured under nearly the same physical and chemical conditions which can be expected in the sinus itself. Each antibiotic substance was studied with three different comcentrations in the culture medium. By extrapolation of the linear regression between some characteristical parameters of the culture absorbancy development and the concentration, the inhibitory concentration can be estimated. The efficacy decreases in the following order: Doxycyclin greater than Gentamycin greater than Ampicillin greater than Lincomycin. An inhibitory concentration results, if the antibiotics are instilled in the sinus itself. The general side effects can be neglected but not at all the local ones. Investigations in this direction are still going on. As a preliminary report, 700 instillations of Lincomycin turned out with no incident.

Administration, Topical

Ethmomaxillary sinus and hypoplasia of maxillary sinus.

In a series of 410 coronal CT scans performed to assess paranasal sinus disease, we have identified eight cases in which an ethmomaxillary sinus was present. The ethmomaxillary sinus was unilateral in five cases and bilaterally present in three. The sex incidence was equal. Four patients had generalized mucosal disease of their paranasal sinuses which included the ethmomaxillary sinus whereas four patients had osteomeatal complex disease and sparing of their ethmomaxillary sinus. The characteristic radiological features of an ethmomaxillary sinus were drainage into an enlarged superior meatus, reduction in the size of the maxillary sinus and a normal bony orbital cavity. The differential diagnosis of an apparently hypoplastic maxillary sinus is briefly discussed.

Congenital Abnormalities

Use of the Silvermann-Franklin biopsy needle for the diagnosis of intra-sinusal lesions, especially of the maxillary sinus.

This report proposes the use of a new technique in the diagnosis of pathology of the maxillary sinus, including neoplasm, using the Silvermann-Franklin" needle. The procedure consists of approaching the diseased sinus through the canine, as in conventional biopsies, with the removal of fragments using forceps. Ten patients with an X-ray suggesting a mass in the maxillary sinus were studied. An 80% correlation was found between the anatomical and pathological findings of the biopsy and the subsequent surgical findings. The advantages of this method include the low risk, performance under local anaesthetic in an out-patient mode, the possibility of obtaining the diagnosis prior to surgery, and the possibility of obtaining deep-seated tissue fragments.

Adolescent

Antibiotic concentrations in maxillary sinus secretions and in the sinus mucosa.

In maxillary sinusitis, the blood circulation is supposed to be impaired in the oedematous sinus mucosa, and in such cases the transport of antibiotics into the maxillary sinus should be reduced. To prove the accuracy of this assumption a comparison has been made between the concentrations of penicillin and doxycycline (Vibramycin, Pfizer) in sinus mucosa and secretions and the serum concentrations in patients under treatment with these antibiotics. Measureable concentrations of penicillin (greater than 0.2 mug/ml) were reached in the secretions only if the serum concentration was high (greater than 4-5 mug/ml). In contrast, measurable concentrations of doxycycline were achieved in both mucosa and secretions in all patients treated with this antibiotic. This must depend on the fact that doxycycline, due to its optimal lipid solubility, was able to penetrate poorly vascularized tissue. In most cases, the concentrations of doxycycline far exceeded the minimum inhibitory concentrations of the isolated organisms, and in some cases the local concentrations were higher than those found in the serum. The clinical response to doxycycline was good and correlated well to the laboratory data.

Doxycycline