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Goals and teaching methods of the urologic core curriculum at the University of Missouri, Columbia.

Urology is a highly specialized surgical subspecialty, but most urologic patients present to the primary physician with variable signs and symptoms. As medical school educators, we are obligated to furnish the students with the knowledge and skills required to handle the patient's initial problem, and refer the patient to a urologic specialist at the optimal time. The Section of Urology, University of Missouri, Columbia, has developed a core urologic curriculum for junior and senior medical students. The goals and methods used to accomplish these goals are presented in conjunction with the goals for the Department of Surgery, University of Missouri, Columbia.

Curriculum

Perinatal deaths in twin pregnancy. A five-year analysis of statewide statistics in Missouri.

Analysis of computer-stored State of Missouri birth and death records over a 5 year period revealed 3,594 twin pregnancies (1.02% of all pregnancies), which accounted for 10.1% of the perinatal deaths. The mean birth weight according to weeks of gestation was computed for the pregnancies with no complications noted prior to labor and the perinatal mortality rate was determined. Complications of pregnancy were evaluated. Low birth weight appears to be the major factor in the elevated perinatal death rate in twin pregnancy, with a significant elevation of the perinatal death rate noted with labor prior to 36 weeks, any episode of hemorrhage, or premature rupture of membranes. A more liberal use of cesarean section currently shows no effect in altering the perinatal mortality rate. Programs are suggested to increase early detection and appropriate consultation and referral of multiple pregnancies in a statewide comprehensive effort to decrease the perinatal mortality rate in twin pregnancy.

Birth Weight

The incidence of anemia in residents of Missouri.

A state-wide nutritional health survey of Missouri residents conducted in 1973 included hemoglobin, hematocrit, and serum iron determinations on approximately 1,164 persons and dietary iron intake estimates, based on a diet history, for 530 persons. Based on the criteria used for interpretation of the Ten-State Nutrition Survey data, over 19% of all preschool age white children and over 10% of the white children six to 10 years old had low or deficient hemoglobin levels. Between 8 and 17% of the white males between 10 and 60 years old and over 30% of the white males over 59 years old were anemic. Between 3 and 9% of all white females over 9 years of age had low or deficient hemoglobin levels. The levels of anemia for most age and sex groups of Negroes were at least twice as great as for corresponding groups of white persons. Low or deficient hemoglobin levels within the age and sex groups were associated with low hematocrit and serum iron levels; suggesting that some of the anemia was a reflection of iron deficiency. Estimates of the dietary intake of iron indicated that less that 20% of the females 10 to 35 years old and less than 60% of older females and boys under 17 years of age were consuming the Recommended Dietary Allowances. Over 35% of the preschool children and females between 10 and 60 years old were consuming less than two-thirds of their Recommended Dietary Allowances for iron. At least part of the iron deficiency was, therefore, indicated to be related to insufficient dietary intake.

Adolescent

Nutritional status of elderly residents in Missouri.

Nutritional assessment of white persons over 59 who participated in the 1973 Missouri Nutrition Survey was based upon biochemical measurements, dietary intakes using food frequency histories, anthropometric measurements, and a dental examination. There were three major nutritionally related problems: poor dental health, obesity, and anemia. The mean for DMF, periodental index, and oral hygiene index for males was 20.5, 4.9, and 3.9, respectively; for females, 17.6, 3.6, and 2.5. Over one-half of both sexes were edentulous. Of the women 59% were greater than 119% of desirable weight compared to 22% of the men. Using guidelines from the Ten-State Nutrition Survey, the following percentages of men had low blood levels: 20, hemoglobin and serum iron; 2, plasma vitamin A; 6, plasma carotene; 1, serum vitamin C; and 0, serum albumin. The percent of women with low biochemical levels were: 11, hemoglobin; 10, serum iron; 7, plasma vitamin A; 1, serum vitamin C; and 2, serum albumin. None of the subjects had low or deficient levels of erythrocyte glutathione reductase. One-half of the women compared to one-fifth of the men had consumed diets with one or more nutrients below 67% of the 1974 Recommended Dietary Allowances.

Aged

The association of obesity with socioeconomic factors in Missouri.

The prevalence of obesity and underweight was estimated for residents of Missouri more than 9 years old on the basis of age, sex, household income, educational attainment, and population density from the results of a survey conducted in 1973. The incidence of overweight was greatest among children 10 to 16 years old and the least for adults 17 to 35 years old. Four percent of the girls 10 to 16 were greater than 159% of average weight for height. Among women greater than 59 years old the incidence of overweight and underweight were high. The proportion of adult women who were overweight as defined by average weight for height and body mass index (W/H2) was inversely related to household income and education. The same was true for adult men in relation to income but the reverse results were observed for education. A larger proportion of urban men were overweight as defined by body mass index compared to rural men. The incidence of obesity among males of all ages and females greater than 59 years old appeared to be related to residence in specific types of communities.

Adolescent

Technology evaluation: a case study of MARS (Missouri Automated Radiology System).

A health care technology evaluation framework is presented along with its application to the Missouri Automated Radiology System (MARS) project. The framework is made up of the following components: evaluation objectives, evaluation design, system documentation, analysis model, evaluation measures, and data collection. The results of applying the framework indicate that MARS incerases the cost of diagnostic radiology 2.3 per cent, significantly decreases report response time, and successfully performs the film management function.

Attitude of Health Personnel

Cadmium in forest ecosystems around lead smelters in Missouri.

The development of Missouri's new lead belt within the past decase has provided an excellent opportunity to study the dissemination and effects of heavy metals in a deciduous forest ecosystem. Primary lead smelters within the new lead belt have been identified as potential sources of cadmium as well as lead, zinc, and copper. Sintering and blast furnace operations tend to produce significant quantities of small particulates highly enriched in cadmium and other heavy metals. At one smelter, samples of stack particulate emissions indicate that as ms accompanied by 0.44 lb zinc, 4.66 lb lead, and 0.01 lb copper/hr. These point-source emissions, as well as a number of other sources of fugitive (wind blown) and waterborne emissions contribute to a significant deposition of cadmium in the surrounding forest and stream beds. Mobilization of vagrant heavy metals may be significantly increased by contact of baghouse dusts or scrubber slurries with acidic effluents emanating from acid plants designed to produce H2SO4 as a smelter by-product. Two separate drainage forks within the Crooked Creek watershed permit some comparisons of the relative contributions of cadmium by air-borne versus water-borne contaminants. Cadmium and other heavy metals have been found to accumulate in the forest litter and partially decomposed litter along stream beds. Greater solubility, lower levels of complexation with organic ligands in the litter, and greater overall mobility of cadmium compared with lead, zinc, and copper result in appreciable contributions of dissolved cadmium to the watershed runoff. The present paper attempts to define the principle sources and current levels of heavy metal contamination and summarizes the efforts undertaken by the industry to curtail the problem.

Air Pollutants

Allergy epidemiology in the St. Louis, Missouri, area. I. Fungi.

1728 patients prick skin tested for eight fungi in the St. Louis, Missouri metropolitan area exhibited overall a rather low level of allergenicity as well as a general lack of cross-reactivity. Alternaria, however, elicited a high allergic reaction in both reactivity level and reaction frequency in the population. Response of pediatric patients was higher than that of adults, and the extract concentration and source varied the allergenic response only slightly.

Adolescent

Allergy epidemiology in the St. Louis, Missouri, area: II grasses.

3219 patients for seven species of grass pollen extracts and mixtures of these grasses in the St. Louis, Missouri, metropolitan area exhibited specific levels of allergenicity to different grasses, as well as a degree of cross-reactivity among all species tested. Adult patient reactions to these extracts generally were similar to those of the pediatric patients tested. Mixed grass pollen preparations proved to be inadequate as a gauge of patient allergenicity to individual species. Intersection of the prick skin testing method and the intracutaneous technique was found at specific concentrations. For the first time phylogenetic and taxonomic conclusions regarding the grass family are supported by immunological data.

Adolescent

Allergy epidemiology in the St. Louis, Missouri, area. IV. weeds.

Weeds elicit two levels of allergenicity, a high level by the Ragweeds and other members of the Asteraceae, and a much lower level by members of the families Amaranthaceae (Pigweed, Western Water Hemp), Chenopodiaceae (Lamb's Quarters, Kochia, and Russian Thistle), and Plantaginaceae (Plantain) in the St. Louis, Missouri area. The frequency of reaction among both adults and children as well as the cross-reactivity values are similarly divided.

Cross Reactions

Concurrent validity of the Missouri Children's Picture Series.

Administered the Missouri Children's Picture Series, a nonverbal objective test of personality to a group of normal (N = 119) children and a group of institutionalized (N = 77) aggressive children. Several of the test scales differed significantly between the two groups. The test scales of Aggression and Maturity showed the most consistent and largest differences; the institutionalized children scored, as a group, higher on Aggression and lower on Maturity Level. IQ was found to be unrelated to test scores among the normal children, but was related significantly to personality test scores among the institutionalized children.

Acting Out

Normative and validity data for the Missouri Children's Behavior Checklist.

Presented normative data, collected on an unselected sample of 302 7- and 9-year-old children, for the Missouri Children's Behavior Checklist. Boys were found to be rated as more deviant than girls, while age, occupation of head of household, and estimated IQ were found to be unrelated to checklist ratings of deviant behavior. The use of a cutting point on the Total Pathology Scale of the checklist derived from the normative data identified a group of clinic children, 89% of whom were found to be in need of professional attention. The potential usefulness of the checklist as an aid in making important clinical decisions is discussed, as is the need for more extensive normative data.

Adolescent

Multiple primary cancers: review of clinical studies from two Missouri hospitals.

A composite review of a series of hospital-based, clinical studies on the prevalence of simultaneous and nonsimultaneous multiple primary cancers, including those in which data were recorded by the life table method for six different series of cancer patients and one "control" series of patients who did not have cancer at first contact is provided. The studies came from Barnes Hospital and the Ellis Fischel State Cancer Hospital (EFSCH) and span the period from 1914 through 1964. The conclusions of the studies support the concept that the presence of one primary cancer neither increases nor decreases the chances for developing additional cancers with the possible exception of a few "target organ" areas. One study of this period showed a nonrandom distribution of patients with multiple primary cancers referred to EFSCH and this observation merits further epidemiologic research.

Adolescent