C-peptide and PGE2 activity during human spaceflight.
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Acute-Phase Reaction↗
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Results for “NASA Experiment Number 178120 2/2”
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Excretion of amino acids by humans during space flight.
UNLABELLED: We measured the urine amino acid distribution patterns before, during and after space flight on the Space Shuttle. The urine samples were collected on two separate flights of the space shuttle. The first flight lasted 9.5 days and the second flight 15 days. Urine was collected continuously on 8 subjects for the period beginning 10 d before launch to 6 d after landing. RESULTS: In contrast to the earlier Skylab missions where a pronounced amino aciduria was found, on shuttle the urinary amino acids showed little change with spaceflight except for a marked decrease in all of the amino acids on FD (flight day) 1 (p<0.05) and a reduction in isoleucine and valine on FD3 and FD4 (p<0.05). CONCLUSIONS: (i) Amino aciduria is not an inevitable consequence of space flight. (ii) The occurrence of amino aciduria, like muscle protein breakdown is a mission specific effect rather than part of the general human response to microgravity.
Aerospace Medicine↗
Plasma amino acids during human spaceflight.
BACKGROUND: The plasma amino acid distribution patterns were measured before, during and after flight on the Space Shuttle. The plasma samples were collected from the four payload crewmembers of the 1993 SLS-2 Columbia Shuttle mission. Samples were taken 45, 15 and 8 d before flight; inflight on days 2, 8 and 12 after launch; post-flight on the day of landing; and again 6, 14 and 45 d after landing. RESULTS: Most of the changes found pertained to the essential amino acids, particularly the branched chain amino acids (BCAA). The principle findings were: a) The plasma aminograms for inflight days 8 and 12 were very similar and both aminograms were very different from that of flight day 2. Flight day 2 was not different from the preflight ground control. b) With increasing time in space, there was an increase in the concentration of leucine and isoleucine in the plasma (p < 0.05). This increase occurred even though dietary BCAA intake was not increased inflight. c) The concentrations of the total essential amino acids and the branched chain amino acids (BCAA) in particular were decreased on the day of landing (p < 0.05).
Amino Acids↗