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At least 19 recordsLinked to original sources
PubMed1987

"Well-differentiated" lymphocytic neoplasms. Immunologic findings correlated with clinical presentation and morphologic features.

The authors studied 48 cases of well-differentiated lymphocytic neoplasms using a panel of monoclonal antibodies applied to frozen sections. Forty-seven tumors expressed monotypic immunoglobulin, one or more B-lineage antigens, and Ia (HLA-DR) antigen. Proliferation centers expressed the T9 antigen and increased numbers of Ki-67-positive cells. One tumor was of T-cell origin, had a cytotoxic/suppressor cell phenotype, and showed anomalous loss of Leu-1 antigen. Immunophenotypic findings were correlated to the clinical presentation and morphologic features of each neoplasm. Sixteen tumors were associated with peripheral lymphocytosis (greater than 4000/cu mm), 13 biopsies were obtained from extranodal sites, 16 tumors had proliferation centers, and 11 neoplasms had plasmacytoid features. The authors found no absolute and few statistically significant immunologic differences between the B-cell tumors according to their clinical presentation or morphologic features. Tumors associated with peripheral lymphocytosis more commonly expressed the Leu-1 antigen (P less than 0.01) and IgD (P less than 0.01) and less frequently were stained by BA-2 (P less than 0.05) and OKT9 (P less than 0.05). Plasmacytoid neoplasms more frequently expressed the Tac (P less than 0.01) and T9 antigens (P less than 0.05), and all expressed kappa light chain (P less than 0.05). Extranodal neoplasms more commonly expressed IgM (P less than 0.01). In contrast to the markedly different clinical presentation and morphologic appearance these tumors may have, the immunologic data suggest that B-cell small lymphocytic neoplasms are relatively homogeneous. For an individual case, immunophenotype does not predict clinical presentation or morphologic features.

Aged↗
PubMed1994

[Evaluation of epithelial ovarian neoplasm immunologic reactivity using monoclonal antibodies].

The reactivity of five monoclonal antibodies against ovarian carcinoma-associated antigens (OC125, OV632, OV-TL3, 8C, 10B) on tissue sections of malignant and benign ovarian neoplasms was estimated and compared using PAP technique. The immunodiagnostic usefulness of OC125 and OV-TL3 antibodies in differentiation between serous and endometrioid ovarian carcinomas was indicated. OV632 monoclonal antibody appears to be a good marker for differentiation between malignant and benign changes in ovary. Difficulties in typing of monoclonal antibodies for immunodiagnostic purposes were pointed out.

Antibodies, Monoclonal↗
PubMed1988

Burkitt's-like lymphoma of T-cell type.

Over an 8-yr period, we studied 29 cases of Burkitt's/Burkitt's-like lymphoma and unexpectedly found 2 Burkitt's-like cases of the T-cell type. One case presented as diffuse adenopathy in a 35-yr-old male. A second case presented as a jaw mass in a 2-yr-old girl with Down's syndrome. Histologically, each case demonstrated usual Burkitt's-like morphology (intermediate-size cells with high nuclear/cytoplasmic ratio, 1 to 3 prominent nucleoli, high mitotic rate, basophilic cytoplasm, and cytoplasmic vacuolation). Ultrastructural morphometric data corroborated the Burkitt's-like nature of these neoplasms. Immunologically, the neoplasms were of "novel" T-cell phenotype, as seen in peripheral T-cell lymphoma (PTL). The cases showed variable expression of activation antigens (e.g., Ia) and weak to moderate expression of proliferation antigens as measured by Ki-67. This modest proliferative activity (less than 25% Ki-67 expression) contrasts with Burkitt's-like lymphomas of the B-cell type which usually show greater than 80% Ki-67 expression. The jaw tumor also demonstrated positivity for human progenitor cell antigen (HPCA) as commonly found in leukemia. Both cases mimic granulocytic sarcoma by virtue of their eosinophilic/myelocytic recruitment--a phenomenon previously reported in association with PTL. The patients have survived 62 wk and 20 wk, respectively, surpassing the survival rates seen in our concurrent B-cell Burkitt's-like lymphomas (12 wk). Burkitt's-like lymphoma of the T-cell type appears to be a distinctive immunological subset of potential clinical and prognostic relevance.

Adult↗
PubMed1983

Gastric lymphoreticular neoplasms: an immunologic study of 36 cases.

Thirty-six lymphoreticular neoplasms involving the stomach were studied by immunologic technics (particularly immunoperoxidase on paraffin sections) for the localization of immunoglobulins, lysozyme, and alpha one-antitrypsin. Fifteen of 29 (52%) primary gastric lymphomas marked as B-cell lymphomas and only one primary gastric lymphoma of true histiocytic type was identified. This is in contrast to the high incidence of true histiocytic tumors reported in some recent studies. Immunoperoxidase on paraffin-embedded and frozen tissues from endoscopic biopsies or surgical resections was particularly useful in confirming the diagnosis of five of seven B-cell immunoblastic sarcomas and 8 of 12 small lymphoid proliferations including two pseudolymphomas. Twenty-two of 29 (76%) primary gastric lymphomas were large-cell lymphomas. The previously reported high incidence of plasma cell tumors could not be confirmed. Atrophic gastritis remote from the neoplasm was noted in 8 of 15 (53%) patients, and this relationship is discussed.

Antibodies, Monoclonal↗
PubMedDate not supplied

[Association of retrovirus D with human malignant neoplasms].

Immunological methods of investigation (CFT, immunofluorescence and radioimmunoassay) showed that the antigen induced by retrovirus D was discovered in some malignant and benign human tumors of various localizations. No association of retrovirus D with human hemoblastoses could be established.

Animals↗
PubMed1980

[Demonstration of an epidermal SH-protease inhibitor in normal epithelium and in some human neoplasms--an immunological study (author's transl)].

Using a specific antiserum, it was possible to demonstrate (with the Ouchterlony-test, immunofluorescence and peroxidase-antiperoxidase reaction) that the epidermal thiolprotease inhibitor was present in all the squamous epithelia tested by us, e.g. oesophagus, vagina and portio. Immunological methods further showed that epidermoid carcinoma of the skin, squamoepithelial carcinomas of the portion and oesophagus, and squamoepithelial carcinoma of the lung contained an immunoreactive protein reminiscent of the epidermal protease. The immunoreactive protein typical of squamous epithelium was also visible in part of the anaplastic lung carcinomas, which means that the determination of the inhibitor may be of significance in the classification of lung tumors.

Carcinoma, Squamous Cell↗
PubMed1978

Resistance of neoplasms to immunological destruction: role of a macrophage chemotaxis inhibitor.

Several tissue culture lines of 6C3HED, a murine lymphoma, were more susceptible to immunologic destruction in vivo than the highly virulent 6C3HED line maintained by serial intramuscular transplantation. The attenuated tissue culture cells were rejected by normal syngeneic recipients, but thymectomized mice were unable to reject attenuated cells. In such mice, the growth rate of attenuated cells was equivalent to the growth rate of virulent cells in normal syngeneic mice. The increased susceptibility of attenuated cells to destruction by syngeneic hosts was shown to correlate with decreased production by the tumor cells of a macrophage chemotaxis inhibitor, and not with altered antigen density. In addition, when inhibitor isolated from virulent cells was administered to mice challenged with attenuated cells, the latter cells became virulent in vivo. When attenuated and virulent cells were administered simultaneously in the same host, the attenuated cells were able to develop into progressively growing tumors. The data suggest that the successful growth of neoplastic cells in normal may require tumor cells to produce factors which subvert the ability of the host to mobilize macrophages rapidly at the tumor site.

Animals↗