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At least 19 recordsLinked to original sources
PubMed1958

The early changes in the axoplasm during wallerian degeneration.

Axoplasmic changes were studied in the saphenous nerve of the albino rat during the early stages of Wallerian degeneration. The axons were examined at 0, 24, and 48 hours after the surgical transection of the nerve. The material was fixed in 2 per cent OsO(4) in phosphate buffer (pH 7.2-7.5) with sucrose (added to a final osmolar concentration of approximately 0.37 M). The earliest changes were seen in the endoplasmic reticulum which became fragmented into rows of small vesicles. Then, between 24 and 48 hours, the neurofilaments underwent complete disintegration and the axoplasm became filled with finely granular material which later formed irregular clumps surrounded by a structureless matrix, probably fluid in vivo. The fragmentation of the neurofilaments was accompanied by pronounced swelling of the mitochondria.

Animals↗
PubMed1961

The application of x-ray diffraction and electron microscopy to the study of human peripheral nerve obtained by biopsy.

Human peripheral nerves obtained by biopsy from patients suffering from neuromuscular disorders have been studied by x-ray diffraction and electron microscopy. Few abnormal diffraction patterns have yet been recorded and their significance is not yet established. Electron micrographs have revealed wide variations in the numbers of myelinated fibres included in the nerve trunks and have facilitated a detailed study of the Schwann cell-axon relationships in the large numbers of unmyelinated fibres always present. Some indications of demyelination have been encountered.

Axons↗