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At least 19 recordsLinked to original sources
PubMed1961

The inheritance of the glucose component of the phage nucleic acids.

The wild type strains of T2 and T6 bacteriophages differ in their host range specificity, efficiency of plating on E. coli K12, and in glucose content. A study of the inheritance of these three differentiating characteristics has revealed that they are transmitted both upon serial passage of the viruses and when the two phages are crossed. It has been found, furthermore, that an extensive recombination takes place upon crossing. Four types of hybrid phages have been isolated from the progeny of crosses, which had a glucose content of one of the parental phages, and either the host range specificity or efficiency of plating or both of the other. The characteristics of each hybrid were found to be hereditarily stable. It has been concluded that the transmission of the characteristics under consideration is determined genetically and that the genes which control them are not closely linked. Since the glucose content of a phage is determined by the degree of glucosylation of its nucleic acid, the T2 and T6 phages apparently contain genes which control certain chemical properties of their nucleic acid.

Bacteriophages↗
PubMed1961

Infectious nucleic acids, a new dimension in virology.

Viral nucleic acids have been found to be infectious for tissues and animals, yet are nonantigenic and resistant to antibodies against whole virus. Other unique properties, such as their host range and their susceptibility to nuclease action, render them a wholly new dimension to be reckoned with in virology. These properties may explain a number of conditions which at present are considered anomalous. The release from infected tissues of even a small proportion of total virus as free nucleic acid could, in an otherwise immune individual, lead to a low level of infection which would, perhaps, explain permanent immunity. If the proportion of nucleic acid is higher, or if the nucleic acid is resistant to nucleases because of an inert envelope, such conditions as "carrier" states-that is, viremias with or without antibodies-are possible. Note added in proof: The recent article by J. D. Ebert and F. H. Wilt (54) came to my attention after the present article was written. Ebert and Wilt's excellent article indicates the impact of the newer knowledge of viral nucleic acids on the ideas developing in the field of embryology.

Animals↗