Anatomical and functional characteristics of fetal neocortex transplanted into the neocortex of newborn or adult rats.
In humans, the cerebral cortex can be affected by a variety of diseases (vascular, traumatic, neurodegenerative, etc.) and, therefore, several experimental studies have been undertaken to determine to what extent transplantation of cortical neurons could prove a useful treatment for cerebral cortical damage. The purpose of this review is to give an evaluation of the different attempts of neocortical tissue transplantation which have been undertaken, mostly in rodents, during the last decade. First, we examine the functional effects of neocortical tissue transplantation in various tasks designed to assess different aspects of behavior depending upon the localization and function of the cortical area under investigation. Second, a variety of mechanisms have been proposed by which the graft would improve host behavioral capacities. Two of these are considered in this review: trophic action on the host brain and reconstruction of cortical circuitry. Most behavioral studies in rodents seem to indicate that better synaptic integration and larger functional improvements are achieved when the embryonic neocortical tissue is transplanted into immature host neocortex, i.e. in newborn recipients. Transplantation of embryonic neocortex into an adult damaged cortex seems to provide only partial functional improvement. In adult hosts, the synaptic integration of the transplanted neurons is incomplete since, in most instances, long distance projections are not re-established. It seems, therefore, that transplantation of embryonic cortex into adult hosts would prove a useful therapeutic method only if there is a possibility of neutralizing the growth inhibitory factors of the mature host CNS.