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Results for “Neovascularization, Pathologic”

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At least 19 recordsLinked to original sources
PubMed1976

Roentgenology-pathology correlative study of neovascularity.

In an attempt to evaluate the histologic picture of what is shown on angiograms as neovascularity, several benign and malignant tumors were examined. New vessels (neovascularity) are large capillaries or sinusoids, and neither contain smooth muscle in their walls. The walls may contain some fibrous connective tissue. Puddling, laking, and staining represent the collection of contrast medium in small capillaries or sinusoids. Some tumors, such as hemangioma of the liver, cystadenoma of the pancreas, and angiomyolipoma of the kidney contained abnormal vascularity, but this was not composed of vessels which had arisen or developed anew, as there was smooth muscle in their walls, and this indicates that those vessels had been there from birth. In xanthogranulomatous pyelonephritis and chronic renal disease, the appearance of increased vascularity is the result of rearrangement of the normal vascular structures.

Angiography↗
PubMed1978

[The tumor angiogenesis factor (TAF)].

The tumor Angiogenesis Factor (T.A.F.) isolated from several human and animal neoplasms by J. Folkman and S. Kumar is a factor that induces the appearance of neovessels in the tumors. After describing the methods of vasculor, physiological, experimental and in some cases pathological proliferation, the author has compared the Angiogenesis in both the natural and neoplastic tissues, then, he's studies the tumoral growth the rate of which regularized by the T.A.F. The proving, the extraction and chemical nature of this factor have been reviewed. Afterwards, the author has called to mind the notion of tumoral ecology and the various possibilities of inhibition of the tumoral growth, that is founded on the inhibition of the Angiogenesis and the therapeutical possibilities of the T.A.F. in the fight against cancer. To end up with his study, the author is now considering the possibility of using the T.A.F., extract of the sarcoma of sticker as a complement to the electontherapy in the treatment of this neoplasm.

Angiogenesis Inducing Agents↗
PubMed2025

The Involvement of PI3K-Akt Signaling in the Clinical and Pathological Findings of Idiopathic Multicentric Castleman Disease-Thrombocytopenia, Anasarca, Fever, Reticulin Fibrosis, and Organomegaly and Not Otherwise Specified Subtypes.

Idiopathic multicentric Castleman disease is a rare lymphoproliferative disorder that is clinically classified into idiopathic plasmacytic lymphadenopathy (IPL); thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly (TAFRO); and not otherwise specified (NOS). Although each subtype shows varying degrees of hypervascularity, no statistical data on the degree of vascularization have been reported. Additionally, the mechanisms underlying vascularization in each clinical subtype are poorly understood. Here, we aimed to clarify these mechanisms by evaluating the histopathological characteristics of each clinical subtype across 37 patients and performing a whole-transcriptome analysis focusing on angiogenesis-related gene expression. Histologically, TAFRO and NOS exhibited a significantly higher degree of vascularization than IPL (IPL vs TAFRO, P < .001; IPL vs NOS, P = .002). In addition, the germinal centers (GCs) were significantly more atrophic in TAFRO than in IPL. In TAFRO and NOS, "whirlpool vessels" in GCs were seen in most cases (TAFRO, 9/9, 100%; NOS, 6/8, 75%) but not in IPL (IPL vs TAFRO, P < .001; IPL vs NOS, P = .007). Likewise, immunostaining for Ets-related gene revealed higher levels in endothelial cells of GCs in TAFRO than in IPL (P = .014), and TAFRO and NOS were associated with a significantly higher number of endothelial cells in interfollicular areas compared with that in IPL (TAFRO vs IPL, P < .001; NOS vs IPL, P = .002). Gene expression analysis revealed that the PI3K-Akt signaling pathway was significantly enriched in the TAFRO and NOS (TAFRO/NOS) groups. This pathway, which may be activated by vascular endothelial growth factor A and some integrins, is known to affect angiogenesis by increasing vascular permeability, which may explain the clinical manifestations of anasarca and/or fluid retention in TAFRO/NOS. These results suggest that the PI3K-Akt pathway plays an important role in the pathogenesis of TAFRO/NOS.

Humans↗
PubMed1979

A modified filtering operation for neovascular glaucoma.

Thirteen patients with useful vision but suffering from uncontrollable neovascular glaucoma due to total angle closure were treated with modified filtering operations. Ten (77%) of the cases were controlled more than one year postoperatively. Most patients whose pressures were controlled maintained their preoperative visual acuities. These visual results appear to be better than those reported with cyclocryotherapy, where vision is usually lost despite satisfactory pressure control.

Adolescent↗
PubMed1979

Iris neovascular tufts. Relationship to rubeosis, insulin, and hypotony.

Iris neovascular tufts are abnormal proliferations of twisted microcapillary loops that project from the iris pupillary border. They appear to be a morphologic variant of rubeosis iridis. This study searched for iris neovascular tufts by biomicroscopy and iris fluorescein angiography. They were found in two of 16 (12.5%) myotonic dystrophy patients, in two of 30 (6.7%) maturity-onset diabetics, and in zero of 14 (0%) juvenile-onset diabetics. Myotonic and adult-onset diabetics have in common pancreatic beta-cell dysfunction, abnormally high serum insulin levels, and possibly defective hormone-receptor interactions. Whether these factors contribute to the altered blood-iris barrier and iris neovascular tufts in these groups is uncertain, but a correlation is suggested because the myotonic with the highest insulin level also had the most prominent tufts. Hyperinsulinemia and ocular hypotony are associated with neovascular tufts.

Adolescent↗
PubMed2025

Inhibitor of DNA binding-1 is a key regulator of cancer cell vasculogenic mimicry.

Solid tumours routinely access the blood supply by promoting endothelium-dependent angiogenesis; but tumour vasculature can also be formed by cancer cells themselves via vasculogenic mimicry (VM). Investigation of the gene expression profile during the early stages of VM formation by MDA-MB-231-LM2 breast cancer cells identified the transcriptional regulator inhibitor of DNA binding 1 (ID1) to be elevated ~&#x2009;10-fold within the first 2&#x2009;hours. This role for ID1 in promoting VM was supported by ID1 genetic knockdown or chemical inhibition interrupting VM formation by MDA-MB-231-LM2 (breast) and BxPC-3 (pancreatic) cancer cells. More specifically, reducing ID1 lowered cancer cell expression of endothelial cell genes (e.g. CDH5, TIE2) and production of pro-angiogenic proteins (e.g. VEGF, CD31, MMP9 and IL-8). In silico analysis of MDA-MB-231 cells engrafted into mice identified elevated ID1 expression in cancer cells that had metastasised to the lungs or liver, and an enrichment of pro-angiogenic genes. Additionally, Id1 knockdown in 4T1.13 murine breast cancer cells demonstrated reduced tumour growth and metastasis in&#xa0;vivo. Taken together, this study further implicates ID1 in a vascular program within cancer cells that supports disease progression.

Humans↗
PubMed1979

Neovascularity related to a mural thrombus.

This is a case report on an unusual angiographic finding related to a left ventricular mural thrombus. An abnormal vascular blush of contrast was noted on performing coronary arteriography. This was attributed to neovascularity in a left ventricular mural thrombus. This abnormality must be distinguished from vascular fistulas, intracardiac communications, and tumors in making appropriate therapeutic decisions.

Heart Ventricles↗
PubMed1978

Pathogenesis of proliferative neovascular retinopathies and the role of vitrectomy. A hypothesis.

Proliferative neovascular retinopathies may be caused by the release of a hypothetical vasoproliferative factor, but mechanical factors seem to self-perpetuate the disease as well. Contraction of proliferative tissue causes vitreous detachment and traction on the retina. Congestion of vascular fronds by traction further stimulates vascularization. Traction on vessels results in hemorrhages. Surgical removal of all intravitreal scaffolds by vitrectomy seems to eliminate the development of this vicious cycle. Results of vitreous surgery seem to indicate that the hypothesis of scaffold removal is valid.

Diabetic Retinopathy↗
PubMed1979

The technique and indications for photocoagulation in diabetic retinopathy. II. The treatment of diabetic retinopathy.

The beneficial effect of photocoagulation in diabetic retinopathy is now established (3-7, 10). Whereas the capability of providing photocoagulation is widespread, the indications and actual technqiues are poorly defined. In an earlier paper (1) we discussed the principles of photocoagulation. In this paper the detailed techniques required for the treatment of individual lesions and of different types of retinopathy will be discussed.

Diabetic Retinopathy↗
PubMed1979

Photocoagulation treatment in diabetic retinopathy: a two-year pre- and five-year post-treatment study.

A randomized controlled study covering a two-year pre-treatment and a five-year post-treatment period was performed in 42 patients with diabetic retinopathy given photocoagulation treatment in one eye. Patients with progressive diabetic retinopathy of equal intensity in both eyes were selected from a single diabetes department. The course of diabetic retinopathy was assessed by ophthalmoscopy and composite fundus photographs as well as fluorescence angiography. In the first two-year post-treatment period non-proliferative retinopathy improved in the coagulated eyes and also, albeit to a lower degree, in the control eyes. In the next three years the treated eyes showed further improvement or stabilization, whereas the control eyes showed either stabilization or deterioration of the retinopathy. The most favourable results were obtained in proliferative diabetic retinopathy, which regressed in the majority of the eyes, the other eyes remaining stable or progressing only very slightly, in contrast with the control eyes, in the great majority of which proliferative diabetic retinopathy developed or progressed.

Adult↗
PubMed1979

Fluorescein angiography and changes in aqueous humor protein after argon laser photomydriasis in rabbits.

In brown-eyed and blue-eyed rabbits, irises treated with argon laser photomydriasis (ALP) were studied by using fluorescein angiography and by evaluating the aqueous humor protein concentration. The following results were obtained. Immediately after ALP, a breakdown of the blood-aqueous barrier is demonstrated by a marked influx of fluorescein into the ciliary processes and into the anterior and posterior chambers. The dye flow into the aqueous humor decreases to normal values within 3 days. There is no fluorescein leakage from laser impacts themselves. Peripupillary capillary loops are permanently occluded, but in a few cases, recanalization occurs. Neovascularization did not occur during 56 days of observation. ALP initially leads to a six- to eightfold increase in normal aqueous humor protein concentration, which decays to normal values within 3 days.

Animals↗
PubMed2026

Integrated analysis of VEGFA rs833061 (-&#x2009;460T&#x2009;>&#x2009;C) promoter polymorphism and serum YKL-40 levels in bladder cancer: evidence of a genotype-phenotype association.

BACKGROUND: Angiogenesis plays a central role in bladder cancer progression. VEGFA regulates angiogenesis, whereas YKL-40 is a pro-angiogenic biomarker. The relationship between VEGFA polymorphism and circulating YKL-40 remains unclear. METHODS AND RESULTS: A hospital-based case-control study involving 120 bladder cancer patients and 120 age- and sex-matched healthy controls was conducted. VEGFA rs833061 genotyping was performed using ARMS-PCR and confirmed by Sanger sequencing. Serum YKL-40 concentrations were measured by ELISA. Multivariable binary logistic regression analysis adjusted for age, sex, and smoking status demonstrated that the CT and TT genotypes remained independently associated with an increased risk of bladder cancer. Serum YKL-40 concentrations were significantly elevated in patients and increased progressively with tumor stage. TT genotype carriers exhibited the highest serum YKL-40 levels. CONCLUSIONS: After adjustment for age, sex, and smoking status, the VEGFA rs833061 polymorphism remained independently associated with bladder cancer susceptibility and circulating YKL-40 concentrations. These findings provide preliminary evidence of a genotype-phenotype relationship; however, validation in larger multicentre cohorts is required.

Humans↗
PubMed1979

The inhibition of corneal vascularization with aortic extracts in rabbits.

A low molecular weight fraction of bovine aortic extract inhibited corneal vascularization and edema in rabbits when administered either subconjunctivally or topically as long as 48 hours after injury. The extract also appeared to enhance the regression of newly formed corneal vessels. Topical administration for as long as two months had no deleterious ocular side effects. Tissue culture experiments showed that analagous fractions prepared from bovine vitreous inhibit endothelial cell growth. The major growth inhibitor of corneal neovascularization was not the Kunitz bovine protease inhibitor.

Animals↗
PubMed1979

Disk and peripheral retinal neovascularization secondary to talc and cornstarch emboli.

A 30-year-old man was examined because of blurred vision. The symptoms had occurred immediately after the patient had injected himself intravenously with crushed, unfiltered, methylphenidate HCl (Ritalin) tablets. Fine yellow-white crystals were scattered throughout the retin of both eyes. The crystals were presumed to be talc emboli. Disk and peripheral retinal neovascularization were present. Fluorescein angiography revealed widespread retinal capillary nonperfusion. This is the first reported case, to the best of my knowledge, of disk neovascularization occurring after intravenously injected, crushed, unfiltered, methylphenidate HCl tablets.

Adult↗
PubMed1979

Direct and indirect laser photocoagulation of central serous choroidopathy.

A 3 1/2-year prospective randomized clinical trial showed a definite superiority of direct argon laser photocoagulation to the fluorescein leaking site compared to indirect treatment away from the leak in patients with central serous choroidopathy. One patient in each treatment group developed a subretinal neovascular membrane after photocoagulation to the fluorescein leak. Moderate prolongation of the neurosensory detachment did not adversely influence the final visual acuity in the indirect treatment group. Although direct laser photocoagulation reduces the duration of central serous choroidopathy, there is a risk of producing subretinal neovascularization. The principles of risk vs benefit should be explained to all patients and treatment should be advised only for compelling reasons.

Adolescent↗
PubMed1979

Natural history of serous detachments of the retinal pigment epithelium.

Fifty eyes of 40 patients with serous (avascular) detachments of the retinal pigment epithelium were followed up for an average of 22 months. Of the 50 eyes, 14 (28%) developed bleeding beneath the retinal pigment epithelium and retina or subretinal neovascularization detected on fluorescein angiography. These changes did not occur in eyes of patients younger than age 56 years at diagnosis or in detachments less than 1 disk diameter in size, whereas 35.9% (14) of eyes in patients older than age 56 years developed vascular complications. Vascular complications were uncommon when the initial detachment did not involve the fovea. Visual acuity declined in only one (9.1%) of eyes in patients younger than age 56 years but in 20 (51.3%) of eyes in patients age 56 years or greater.

Adult↗
PubMed1979

Serous detachments of the retinal pigment epithelium in patients with senile macular disease.

Thirty-one patients had senile macular disease with serous detachments of the retinal pigment epithelium without evidence of choroidal neovascularization. Of these 31 patients the natural history of 24 eyes was compared with 21 eyes treated with photocoagulation. Eight patients with bilateral detachments had treatment applied to one eye. There was no conclusive evidence that photocoagulation alters the natural course of this condition.

Aged↗