Nutritional changes in patients with cancer.
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Energy Metabolism↗
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Results for “Nutrition--changes”
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Ribosome biosynthesis in Tetrahymena pyriformis. Regulation in response to nutritional changes.
Ribosome contents of growing and 12-h-starved Tetrahymena pyriformis (strain B) were compared. These studies indicate that (a) starved cells contain 74% of the ribosomes found in growing cells, (b) growing cells devote 20% of their protein synthetic activity to ribosomal protein production, and (c) less than 3% of the protein synthesized in starved cells is ribosomal protein. Ribosome metabolism was also studied in starved cells which had been refed. For the first 1.5 h after refeeding, there is no change in ribosome number per cell. Between 1.5 and 2 h, there is an abrupt increase in rate of ribosome accumulation but little change in rate of cell division. By 3.5 h, the number of ribosomes per cell has increased to that found in growing cells. At this time, the culture begins to grow exponentially at a normal rate. During the first 2 h after refeeding, cells devote 30-40% of their protein synthetic activity to ribosomal protein production. We estimate that the rate of ribosomal protein synthesis per cell increases at least 80-fold during the first 1-1.5 h after refeeding, reaching the level found in exponentially growing cells. This occurs before any detectable change in ribosome number per cell. The transit time for the incorporation of these newly synthesized proteins into ribosomes is from 1 to 2 h during early refeeding, whereas in exponentially growing cells it is less than 30 min. The relationship between ribosomal protein synthesis and ribosome accumulation is discussed.
Animals↗
Effects of temperature and nutritional changes on the fatty acids of agmenellum quadruplicatum.
The fatty acid composition of the blue-green bacterium Agmenellum quadruplicatum was examined under a wide variety of growth conditions. The fatty acid composition was found to undergo significant changes with variations in temperature, media composition, and growth phase (log versus stationary). With increasing growth temperature (20 to 43 C) log-phase cells exhibited an increase in saturated fatty acids (38.4% at 20 C to 63.6% at 43 C). Striking changes were seen with some of the individual fatty acids such as 18.3, which made up 16.0% of the total fatty acid at 20 C but was not neasurable at 43 C. Fatty acid 12:0 was not measurable at 20 C but made up 16.3% of the total fatty acids at 43 C. Cell lipids were separated into neutral lipid, glycolipid, and very polar liquid fractions. The neutral lipid fraction was composed almost entirely of 12 carbon fatty acids (12:0, 12:1). Glycolipid and very polar lipids were more similar in their fatty acid composition when compared to the total cellular fatty acids, although they did lack 12 carbon fatty acids. The total of 12 carbon fatty acids in the cell can be used as an indicator of the amount of neutral lipid present.
Culture Media↗
[Effect of nutritional changes on fatty acid synthesis in rat liver microsomes. Role of cyclic AMP].
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Animals↗
[Utilization of pure proteins and peptides for the study of chemical and nutritional changes suffered by milk during heating].
Milk proteins, and in particular the caseins, undergo during heat treatments (120 degrees C, 20-30 min) physico chemical and nutritional modifications. Using pure proteins (alphas and beta caseins) and peptides, it has been possible to dissociate the effects of heat treatments which, in milk can hide each other. Physico chemical properties of caseins (the ability to bind Ca++ and anionic dyes, acid-basic titration curves, electrophoretic behavior) are strongly altered, while the constitutive aminoacids are less modified. The accessibility of the aminogroups of lysine to the fluorodinitrobenzen and to the O-méthylisourea is lowered with a small rate. Lysinoalanyle interactions between serine and lysine are weak at a neutral pH while the isopeptide bonds epsilonN (gamma glutamyl)lysyle are only produced with more severe conditions as those of sterilization. The digestibility to the proteases is enhanced with low heat treatments then decreases with more severe treatments (120 degrees C-80 min.). Many peptides, which are released from the caseins during heating are issued from low specific split peptidic bonds; these peptides have often stimulating properties on the growth of lactic bacteria.
Amino Acids↗
Abnormalities of zinc and copper during total parenteral nutrition.
Changes in serum zinc and copper levels were studied in 19 tumor bearing patients undergoing parenteral nutrition (TPN) for five to 42 days. Before initiation of intravenous feeding mean serum zinc and copper concentrations were within normal limits but during TPN levels decreased significantly below those measured prior to parenteral nutrition. During TPN nitrogen, zinc, and copper intake, urinary output and serum levels were studied prospectively in nine of these patients. These nine patients exhibited positive nitrogen retention based upon urinary nitrogen excretion, but elevated urinary zinc and copper excretion and lowered serum zinc and copper concentrations. Neither blood administration nor limited oral intake was consistently able to maintain normal serum levels of zinc or copper. Zinc and copper supplementation of hyperalimentation fluids in four patients studied for five to 16 days was successful in increasing serum zinc and copper levels in only two. The data obtained suggest that patients undergoing parenteral nutrition may require supplementation of zinc and copper to prevent deficiencies of these elements.
Adolescent↗
Effect of cyclic AMP on chromatin-bound protein kinases in WI-38 fibroblasts stimulated to proliferate.
When resting confluent monolayers of WI-38 fibroblasts are stimulated to proliferate by serum, DNA synthesis begins to increase between 15-18 h after stimulation. Chromatin-bound protein kinase activity increases in stimulated cells within 1 h after the nutritional change, concomitant with an increase in the template activity of nuclear chromatin. Addition of dibutyryl 3' : 5'-cyclic adenosine monophosphate (dibutyryl cyclic) AMP to the stimulating medium inhibits the entrance of cells into S phase, but only if dibutyryl cyclic AMP (5-10(-4) M) is added before the onset of DNA synthesis. The increases in chromatin template activity and in the chromatin-bound kinase activity are not inhibited by dibutyryl cyclic AMP in the early hours after stimulation, but are completely inhibited after the 5th hour from the nutritional change. This seems to indicate that in stimulated WI-38 cells, dibutyryl cyclic AMP exerts its inhibitory action somewhere between 5 and 12 h after stimulation. A number of protein kinase activities were extracted from chromatin with 0.3 M NaCl and partially resolved on a phosphocellulose column. Two distinct peaks of protein kinase activity appeared to be markedly increased in WI-38 cells 6 h after serum stimulation. Both peaks of increased activity were inhibited by dibutyryl cyclic AMP in vivo. Adenosine, sodium butyrate and adenosine 5'-monophosphate (AMP) do not inhibit the increase in DNA synthesis nor the increase in protein kinase activity. The results suggest that stimulation of cell proliferation in confluent monolayers of WI-38 cells causes an increase (or the new appearance) of certain chromatin-bound protein kinases, and that this increase is inhibited by cyclic AMP in vivo.
Bucladesine↗
The responsibilities of intervention in isolated societies.
Development pressures are pushing industrial society into the remaining refuge areas of the world. As it spreads it destroys much of the biological and cultural variety that has evolved over millions of years. Not only is mammalian life diminishing, but also the genetic pool of plants and cultivars, as well as the culture-specific knowledge of their use. Even culture itself, the highest attribute of mankind, is being rapidly erased, often before any attempts are made to record it. The medical problems of remaining tribal groups are severe. Western medicine has developed to deal with western problems and is often poorly equipped to deal with the many-sided health hazards of tribal man. The effects of contact upon disease status are discussed with particular reference to North and South American Indian history. Infectious disease is only one of many causes of ill-health, and the problems of nutritional change and social disruption are also considered. The approach to health care in tribal communities is discussed and axioms for the initiation of health care programmes are proposed.
Acculturation↗
The ultrastructure of cutaneous type I mechanoreceptors (Haarscheiben) in cats following denervation.
Denervation of specialized cutaneous mechanoreceptors (Haarscheiben or domes) in cats was followed after 20 and 25 days by the following alterations in receptor structure: (1) reduced numbers of Merkel cells, (2) Merkel cells degenerating in situ, (3) fewer dense-core granules in the cytoplasm of Merkel cells, (4) an increased number of agranular dendritic cells and Langerhans cells in the dome, (5) the apparent phagocytosis of Merkel cells by Schwann and Langerhans cells, (6) fewer epithelial cell layers over the dome, and (7) a decrease in the number of transitional cells. Skin excised between the domes in the denervated nerve field appeared normal when compared to innervated skin, and it was considered unlikely that the alterations in dome structure were due to generalized nutritional changes in the skin caused by transection of sympathetic axons or to some other side effect of denervation. Since domes are formed in new locations on the skin after nerves have regenerated (Burgess et al., '74), changes in dome structure following nerve transection are probably due to loss of the "trophic" influence of the nerves supplying the dome.
Animals↗
Preventive trials and the "diet-heart" question: wait for results or act now.
Is the relationship between coronary heart disease risk factors and the risk of disease causal? Direct evidence would have to come, of necessity, from preventive trials. However, the difficult nature of such trials carries the inherent danger of false negative results; even positive results may be open to challenge. With regard to demonstrating specifically a preventive effect of lowering serum lipid levels through nutritional changes alone, this evidence may never be forthcoming since ongoing trials intervene simultaneously on multiple factors; against this disadvantage, the strengths of such trials are reviewed. The view is stated and discussed that preventive action in the community is justified now, without waiting for the results of preventive trials, however important they will be eventually to help the development of optimally effective programs.
Arteriosclerosis↗
A national food policy for prevention of CHD?
There is an increasing recognition of the importance of diet in the prevention of CHD. Dietary recommendations of various authoritative bodies are summarized. There is now a concensus of opinion concerning certain nutritional changes needed. These have important implications for education, agriculture, food labelling and food subsidies. It is concluded that a national food policy is needed, but that this should come from education and persuasion and not from compulsion.
Coronary Disease↗
Fetal growth retardation following maternal morphine administration: nutritional or drug effect?
The effects of maternal morphine administration on maternal nutrition and on fetal growth have been systematically examined in a rabbit model. Significant alterations in maternal food intake occurred morphine exposure. These nutrition changes did not result in fetal growth retardation. Fetal morphine exposure was associated with significant reductions in fetal weight, length, placental weight and in the weights of most organs including the brain. When organ weight was considered as a fraction of total fetal weight morphine exposure was associated with a significant increase in the relative weight of the brain and a significant decrease in the relative weight of liver and kidneys. These narcotic effects were dose dependent.
Animals↗
Changes in the adrenergic control and the rate of lipolysis of isolated human adipose tissue during fasting and after re-feeding.
The influence of changes in nutritional state on lipid mobilization has been investigated, using subcutaneous fat portions removed from 8 obese patients submitted to fasting for one week. The maximal rise in the tissue level of cyclic AMP (cAMP) and the rate of glycerol release were determined when adipose tissue was exposed to noradrenaline (6 X 10(-6) mol/1), isopropylnoradrenaline (6 X 10 (-6) mol/1) or none of the agents (basal medium). Fasting resulted in significant increases in the tissue level of cAMP and the rate of lipolysis in adipose tissue unexposed to lipolytic agents. Noradrenaline decreased the level of cAMP, in contrast to isopropylnoradrenaline, and significantly inhibited the rate of lipolysis during fasting. These noradrenaline effects were abolished by the simultaneous presence of phentolamine (13 mmol/1) in the incubation medium. Re-feeding with Meritene for one day resulted in a diminished rate of basal lipolysis, whereas the cAMP level was unaffected. The response of the cAMP accumulation to isopropylnoradrenaline was further augmented by re-feeding. Noradrenaline produced a significant rise in the level of cAMP and significantly stimulated the rate of glycerol production. It is concluded that the nutritional changes are of significance for the adrenergic regulation of lipolysis as indicated by the response of cAMP to the catecholamines. In pharmacological terms, fasting for one week resulted in increased alpha-as well as beta-adrenergic responsiveness. Increased basal lipolysis during fasting may be related to an increased level of cAMP or a direct activation of lipase.
Adipose Tissue↗
Complications of jejunoileal bypass.
Jejunoileal bypass for morbid obesity is accompanied by excessive morbidity and significant mortality. Weight loss is achieved at the expense of major nutritional changes which in and of themselves produce complications. The operation should be considered investigational and be limited to those centers with special interest in the problem and where longterm follow-up and management can be carried out.
Adult↗
Reducing the risk of cardiovascular disease: effects of a community-based campaign on knowledge and behavior.
In 1972 the Stanford Heart Disease Prevention Program launched a three-community field study. A multimedia campaign was conducted for two years in two California communities (Watsonville and Gilroy), in one of which (Watsonville) it was supplemented by an intensive-instruction program with high-risk subjects. A third community (Tracy) was used as a control. The campaigns were designed to increase participants' knowledge of the risk factors for cardiovascular disease, to change such risk-producing behavior as cigarette smoking, and to decrease the participants' dietary intake of calories, salt, sugar, saturated fat, and cholesterol. Results of a sample survey indicate that substantial gains in knowledge, in behavioral modification, and in the estimated risk of cardiovascular disease can be produced by both methods of intervention. The intensive-instruction program, when combined with the mass-medica campaign, emerged as the most effective for those participants who were initially evaluated to be at high risk. The results after two years of intervention are reported for effects on knowledge and behavioral change for the total participant samples and for the high-risk subsamples in each of the three communities.
Attitude to Health↗
World trends in infant feeding.
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Breast Feeding↗
Nutritional evaluation of breast-feeding practices in some countries in the far east.
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Breast Feeding↗
The infant food industry and international child health.
Declining breast-feeding, with accompanying increased marasmus and diarrhea, has occurred in developing countries because of many factors, including inappropriate health services, new urban life styles, and so forth. The infant food industry must bear a considerable burden of blame as a result of "unethical" advertising. Responses have most recently included various journalistic and legal actions. There is a need for revised roles for the infant food industry, and for mechanisms to monitor intrinsically harmful practices.
Advertising↗