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[Connection of immune status, nutritional status and postoperative complications in patients after surgery for organic esophageal stricture].

The postoperative complications were analysed in 64 patients after operation for stricture of the esophagus. The underfeeding in consequence of the esophagus stricture reduced the cellular immune functions and increased the operative risk. The comparison of the feeding and immune parameters of patients with benign and malign strictures of the esophagus showed that the poor immune reactivity is caused by the underfeeding first of all and not by the immune depression due the tumor.

Esophageal Neoplasms

Immunocompetence is a sensitive and functional barometer of nutritional status.

Nutrition is a critical determinant of immunocompetence and risk of illness. Young children with protein-energy malnutrition exhibit increased mortality and morbidity, due largely to infectious disease. Recent work has demonstrated that undernourished individuals have impaired immune responses. The most consistent abnormalities are seen in cell-mediated immunity, complement system, phagocytes, mucosal secretory antibody response, and antibody affinity. Many of these immunologic changes occur early in the course of nutritional depletion and therefore can serve as sensitive functional indices of nutritional status.

Child

[Effect of student knowledge in gastronomy schools and origin of residence on their nutritional habits and nutritional status].

Nutritional habits and nutritional status of 142 pupils of a Gastronomic School Complex were examined from the standpoint of the year of school, school marks and place of residence. It was found that the year of school and place of residence exerted an effect on the nutritional habits of pupils. These young people failed to prefer dishes and food products recommended in the prophylaxis of civilization diseases. In all subjects the levels of total lipids and beta-lipoproteins exceeded the upper range of the norm. Hemoglobin concentration fluctuated within the lower range of the norm, and that of glucose--within the upper range of the norm. When completing school, the pupils displayed a lowered protein level and elevated glucose level. Pupils inhabiting the school boarding house ought to take part in the decisions on the menu and on food purchases. Recommendations concerning nutrition in the prophylaxis of civilization diseases ought to be as soon as possible introduced into the teaching program of the Gastronomic School Complex.

Feeding Behavior

Effects of type of dietary protein on acid-base status, protein nutritional status, plasma levels of amino acids, and nutrient balance in the very low birth weight infant.

STUDY OBJECTIVE: To determine the effect of the type of dietary protein (3.3 gm/kg per day) on acid-base status, protein nutritional status, plasma amino acid concentrations, and nutrient (nitrogen, fat, mineral, trace element) balance. SUBJECTS: Preterm infants (birth weight less than or equal to 1250 gm, gestational age less than or equal to 32 weeks) with no evidence of systemic disease, who had achieved a minimal enteral intake of 110 kcal/kg per day by 21 days of age. INTERVENTIONS: Each infant was fed three study formulas that differed only with respect to the ratio of whey to casein (60:40, 35:65, 18:82). Each formula was given for 1 week. At the end each week, blood was drawn and a 48-hour balance was determined. MAIN RESULTS: Late metabolic acidosis, uremia, and hyperammonemia were not observed. No differences in pH or serum bicarbonate were noted. Base excess was greater with the casein-predominant formula (18:82 greater than 35:65, 60:40) but remained within normal limits for the preterm infant. Plasma concentrations of threonine (60:40 greater than 35:65 greater than 18:82), phenylalanine, and tyrosine (18:82 greater than 35:65 greater than 60:40) differed. Nitrogen absorption (60:40 less than 35:65, 18:82), nitrogen retention (60:40 less than 35:65, 18:82), fat absorption (60:40, 35:65 greater than 18:82), and phosphorus absorption (60:40 less than 35:65, 18:82) also differed. CONCLUSIONS: At an intake of 3.3 gm/kg per day, the type of dietary protein had little effect on metabolic status. Differences in plasma amino acid concentrations and nutrient balance suggest that a formula containing protein with a whey/casein ratio of 35:65 may be preferable to that with a whey/casein ratio of 60:40 or 18:82 for the very low birth weight infant.

Acid-Base Equilibrium

[Influence of chronic renal failure on nutritional status. Principles of nutrition].

Chronic renal failure influences the metabolism of nutrients. Low protein diet has been found very helpful in a longer survival of uremic patients, before they start some kind of dialysis (hemodialysis or peritoneal dialysis). Such a diet should be followed very carefully in order to avoid problems with patient's nutrition. The evaluation of nutritional status (history, body weight, anthropometric indices, biochemical parameters) is necessary. Moreover, the nephrology team should know the protein and potassium content of different nutrients for the purpose of a better nursing of chronic renal patients.

Diet

Plasma sex steroid-binding protein in mature heifers: effects of reproductive status, nutritional level, and porcine growth hormone, and estradiol-17 beta treatments.

In heifers, the specific 5 alpha-dihydrotestosterone (5 alpha-DHT) binding to sex steroid-binding protein (SBP) was 53 nM in midluteal phase and was 20% lower (p less than 0.05) in early luteal phase. In ovariectomized heifers on a high (H) or a low (L) energy diet, SBP bound testosterone with high specificity and estradiol-17 beta (E2) with a lower specificity; the affinity constant with 5 alpha-DHT was similar in the two groups independent of diet (Ka = 1.0 and 1.3 x 10(9) x M-1 for H and L heifers, respectively). Electrophoretic mobility of SBP was not affected by undernutrition. The specific 5 alpha-DHT binding to SBP in anestrous heifers compared to heifers in early luteal phase was 17% lower 18 days after cessation of ovarian activity (p less than 0.05) and 35% lower after 78 days of anestrus (p less than 0.001). Specific 5 alpha-DHT binding to SBP was 33% lower (p less than 0.001) in L heifers than in H heifers (40 nM). Porcine growth hormone (pGH) and E2 injections increased specific 5 alpha-DHT binding to SBP in both H and L heifers, but the effect depended on diet. Simultaneous injections of pGH and E2 increased specific binding in H heifers (p less than 0.02), whereas it had no effect in L heifers. We conclude that SBP binding capacity varies with ovarian activity in heifers and that nutritional status is one factor of regulation of SBP binding capacity because it affects binding and modifies the SBP response to stimulating factors such as pGH and E2.

Animals

Iron status, energy intake, and nutritional status of healthy young Asian children.

The iron status, dietary intake, and protein energy nutritional status of healthy Asian children ranging in age from 4 to 40 months was investigated. The serum ferritin, erythrocyte zinc protoporphyrin, haemoglobin and mean corpuscular haemoglobin concentrations, and mean corpuscular volume were determined in a community study of 138 children. Protein energy nutritional status was estimated by anthropometry and a four or five day weighed dietary inventory was completed by 97 children. Concentrations of the serum ferritin, haemoglobin, and mean corpuscular haemoglobin, and the mean corpuscular volume decreased progressively with increasing age. The mean values for these four indices were significantly lower in toddlers between 21 and 23 months age than in infants less than 6 months old. The mean erythrocyte zinc protoporphyrin was high in the first six months, later falling and rising again to peak in the 21 to 23 month age group. Thirty five per cent of children were iron deficient (serum ferritin concentration less than 10 micrograms/l) and low values for the mean corpuscular volume and mean corpuscular haemoglobin were observed in 33% and 35% respectively and 17% were anaemic (haemoglobin concentration less than 110 g/l). No association was observed between biochemical iron status and the dietary intake of energy or iron. Nor was there an association between protein energy nutritional status and iron status. Screening for iron deficiency in communities at risk is recommended and nutrition education using trained link workers is preferred to prophylactic iron treatment.

Age Factors

The link between nutritional status and clinical outcome: can nutritional intervention modify it?

Most clinicians subjectively feel that malnutrition in surgical patients is associated with poor clinical outcome. This overview provides a chronologic review of studies relating poor nutritional status to increased surgical morbidity. Techniques for identifying surgical patients with clinically important nutritional deficits are discussed. Retrospective and/or non-randomized clinical studies evaluating the efficacy of perioperative forced feeding are reviewed. These data suggest a possible role for preoperative nutritional support of selected malnourished surgical candidates and provide the rationale for a large-scale nutrition-intervention clinical trial.

Clinical Trials as Topic

Health status of hostel dwellers. Part III. Nutritional status of children 0--5 years.

The standards laid down by the National Center for Health Statistics in the USA were used to assess the nutritional status of children (0--5 years) in the Zones, an urban migrant council-built hostel complex in Langa, outside Cape Town. Of the children, 5.7% were below the 3rd percentile of weight-for-age (acute undernutrition). There was a significant difference between age categories and an increase in age was associated with an increase in proportion of children below the 3rd percentile. Acute undernutrition was significantly higher for children born outside Cape Town. There was a significant difference between age groups and percentage of children below the 3rd percentile of height-for-age (chronic undernutrition). Chronic nutritional levels were also significantly higher for children not born in Cape Town. Yet there were no significant differences between proportions of children under the 3rd percentile of height-for-weight (current nutritional status) for age category or place of birth. These results suggested that while in town children were adequately nourished, this was not the case at their home-base. Chronic undernutrition findings indicated an incremental negative effect of the poverty of the home-base on the long-term health status of hostel migrant children.

Age Factors

Nutrition and aging: nutritional status of "apparently healthy" elderly (Dutch nutrition surveillance system).

In a nationwide survey the nutritional status was assessed of 539 apparently healthy, independently living elderly aged 65-79 years. Anthropometric data showed no energy deficits. The prevalence of anemia was 4 and 1% among men and women, respectively. Many elderly showed a low level of 25-hydroxyvitamin D in plasma (less than 31 nmol/L: men 35%; women 43%), indicating a marginal status. Although the prevalence of low blood levels of folate, pyridoxal-5'-phosphate, and total carotenoids was higher among the elderly than among younger adults, clear (clinical) signs of nutritional deficiencies were not observed. Prevalence of obesity (13%), hypercholesterolemia (38%), and hypertension (63%) was found to be high, the percentages being higher for women than for men. Several indicators of the nutritional status appeared to differ among age groups. It is concluded that few differences can be considered as being due to physiological aging, which finding should be reflected in reference values for elderly people.

Age Factors

Long-term effects of a vegetarian diet on the nutritional status of elderly people (Dutch Nutrition Surveillance System).

The health and nutritional status (anthropometry, and blood and urine biochemistry) of 44 Dutch apparently healthy vegetarians, aged 65-97 years, refraining from meat, fish, and poultry consumption, was assessed for insight into long-term consequences of ovo-lacto- or lacto-vegetarianism. The results indicate that in comparison to omnivorous elderly the vegetarian elderly (especially men) have aged successfully with respect to cardiovascular risk factors. In contrast, vegetarian elderly are at a higher risk for a marginal iron, zinc, and vitamin B12 status. Although several vegetarian elderly showed low levels of 25-hydroxyvitamin D in plasma and many had low values of 24-hr urine volume (per kg body weight), these values are not likely the result of a vegetarian diet per se. It is concluded that, although some nutrition-related risks are prevalent among vegetarian elderly, these risks can probably be prevented by lifestyle changes.

25-Hydroxyvitamin D 2

Nutritional status measures as predictors of nutritional risk in preschool children.

Data from 19 dietary and biochemical indices of nutritional status for 419 participants in the Preschool Nutrition Survey were analyzed to determined the smallest number of variables that could be used to identify all children with any of measure below a criterion of adequacy. Serum transferrin iron and dietary iron intake identified 74% of those at nutritional risk. Additional information on dietary calories, calcium, ascorbic acid, thiamin, and vitamin A identified all subjects at risk.

Ascorbic Acid Deficiency

[Assessing nutritional status].

Malnutrition is associated with a delayed recovery from illness and an increased rate of complications. Heart failure, respiratory diseases, impaired immune function and postoperative wound healing are influenced by the nutritional status. Nutritional assessment includes patients history, physical examination, anthropometric measurements, laboratory dates and changes of immunocompetence. Anthropometric assessment, like skinfold and muscle area measurements, is not an extremely accurate method predicting nutritional status of an individual patient. Multifactorial influence on the concentration of the serum proteins, albumine, transferrin and retinolbinding protein caused a wide range of normal values. Therefore the validity and sensitivity of these parameters to assess nutritional status are diminished for the individual patient. The concentration of serum albumin seems to be of some value as a marker for nutritional status. The influence of malnutrition on immunity is complex. There are no sensitive markers available to assess the influence of malnutrition on the immuno competence of an individual patient for the clinical routine. Malnutrition may be assessed and the resulting clinical complications may be predicted by calculating a prognostic nutritional index, which include several nutritional parameters.

Anthropometry

Effect of giardia infection on nutritional status of preschool children.

Nutritional status of 34 children aged 24-72 months and infected with giardia was compared with that of 92 children matched for age, sex and income and 34 children matched for age, sex, income as well as birth order. Children without giardiasis were found to have better nutritional status in both comparisons. The difference was more pronounced in the second instance. Of the seven anthropometric parameters used for comparison, four were significantly lower (weight, weight for age, midarm circumference and midarm circumference for age), while two (height for age and weight for height) showed nonsignificant childhood malnutrition and that matching for birth order enhances the utility of case-control studies in children.

Anthropometry

Nutritional status of main food preparers and of nutrition education assistants.

The dietary habits and nutritional status of nutrition education assistants (NEAS) in the Expanded Food and Nutrition Education Program in Missouri were compared with a representative population of Missouri main food preparers (MFPs) from the same regions of the state. Dietary histories indicated that the NEAs tended to have better habits than the MFPs. Using biochemical parameters for determining status for iron, vitamin A, ascorbic acid, and riboflavin, the differences between the two groups were not as great as for the dietary intakes. However, almost half of the MFPs were taking at least one vitamin or mineral supplement compared with 17 per cent of the NEAs. A low dietary intake, coupled with some anemia, probably relating to a low iron intake, was a major nutritional problem for both groups of subjects. Low plasma vitamin A values were also observed among a large proportion of both groups, and obesity was a widespread problem for both groups.

Adult

Monitoring nutritional status in the critically ill adult.

Nutritional support is an important aspect of the multidisciplinary approach to critical care medicine. During stress, visceral protein turnover is increased. However, muscle and connective tissue proteolysis is obligatory if the stressful condition persists. Through nutritional support, peripheral protein breakdown is minimized and visceral protein synthesis maximized. A delivery system of 15% to 20% dietary protein, 30% fat, 50% to 55% carbohydrate, complemented by moderate amounts of vitamins and minerals, is considered best. Optimal nutritional care depends on objective assessment of the patient's nutritional status before and during nutritional support, particularly the nutritional status of the body cell mass and the energy required for maintenance and support of reparative processes. Indicators least disturbed by factors should be selected for assessment. Individual indicators vary in critical states. After resuscitation, excess body water may increase body weight; after surgery, stress may depress albumin levels. Biometric markers of nutritional status and measurements that adequately validate and evaluate response to nutritional support are discussed.

Anthropometry

Socio-economic, health and nutritional status of the villagers in the Nong Wai irrigation area, Khon Kaen, Northeast Thailand.

Studies were carried out from June 1974 to May 1975 on the socio-economic status, health and nutritional status of the people in 4 villages, in the irrigation area of the Nong Wai Pioneer Agricultural Project of Khon Kaen Province, Northeast Thailand. The result obtained were compared with those in 2 non-irrigated villages in the same province, in order to identify the health and nutritional problems which might arise during the water resource development in the irrigation area. It was found that in the irrigated villages 90% of the peoples were farmers, while in the non-irrigated villages all were farmers. The socio-economic status of the people in the irrigated villages was much better than those in the non-irrigated ones. The income per family in the former was about three times greater than that in the latter. In the study of the health conditions of the villagers, the vulnerable age group including pre-school children under 7 years of age and school children in the elementary school class 1 and class 2, aged 7-9 years old, served as subjects for investigation. Haematological and physical examinations revealed many children with mild to moderate anaemia, vitamin B2 deficiency and a few cases of hepatomegaly. Anaemic children were found to be more prevalent in the non-irrigated villages than in the irrigated area. The overall parasitic infection rates in children in the irrigated and non-irrigated villages were similar with respect to severity of the infection. Hookworm infection, opisthorchiasis, strongyloidiasis and giardiasis were the leading parasitic infections, while amoebiasis was rare. Ascariasis and trichuriasis were not found. However, the first two helminthic infections had a low grade of intensity. The nutritional status of pre-school children, showed that there were more children with good growth in the irrigated villages than in the non-irrigated one. Serum proteins, albumin and globulin, and urinary urea nitrogen-creatinine ratio revealed normal findings indicating that the children had sufficient protein intake. The results of the urinary hydroxyproline-creatinine index suggested that many of the children in both groups of the villages were at marginal malnutrition status. Surveys on domestic animals including cattle, buffaloes, pigs, and field rats revealed no important zoonotic diseases except leptospirosis in a few rats. Some fish were found to harbour metacercariae of Opisthorchis viverrini, while some snails were positive for cercariae of O. viverrini, Schistosoma spindale, and Echinostoma malayanum. The overall findings indicated that the water resource development by establishing better irrigation, resulted in an improved socio-economic and nutritional status among the villagers, but health conditions and associated parasitic diseases and some nutritional deficiency still existed in the children. However, the findings from this study provide only preliminary data concerning the socio-economic status, health, and nutritional status of the villagers in the irrigation area...

Adolescent