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At least 19 recordsLinked to original sources
PubMed1983

Combined epithelial odontogenic tumor: adenomatoid odontogenic tumor and calcifying epithelial odontogenic tumor.

1. Two cases of a combined epithelial odontogenic tumor which had areas of AOT and CEOT were presented. 2. A review of the studies on histogenesis of the AOT revealed that the tumor probably consists of preameloblasts, stratum intermedium, and stellate reticulum. 3. A review of the studies on histogenesis of the CEOT revealed that the probable origin was in cells of stratum intermedium. 4. It is suggested that the present cases support the aforementioned theories of histogenesis and represent AOT's which contain foci of CEOT. 5. The suggested treatment is simple surgical excision.

Adolescent↗
PubMed2003

Genetic expression profiling of six odontogenic tumors.

Odontogenic tumors are rare neoplasms arising from the odontogenic apparatus. We aimed to identify molecular characteristics associated with odontogenic tumorigenesis and malignancy. To this end, we investigated the expression level of human genes by using, for the first time in odontogenic tumors, the technique of expression profiling. Gene expression alterations common to all six odontogenic tumors were identified by the use of cDNA microarrays containing 19,000 human cDNAs. Statistical analysis on a subset of 4974 cDNAs present in the biopsies identified 506 distinct genes associated with the tumors (p-value < 0.01). Gene ontology analysis of the cellular processes which were differentially regulated in odontogenic tumors was accomplished by the use of a subset of 1409 annotated genes. Finally, 43 cDNAs differentiated the three malignant odontogenic tumors (ameloblastic carcinoma, clear cell odontogenic tumor, granular cell odontogenic tumor) from the three benign ameloblastoma biopsies (p < 0.01). The identified genes might help us better classify borderline odontogenic tumors.

Ameloblastoma↗
PubMed2006

Molecular pathology of odontogenic tumors.

Odontogenic tumors are lesions derived from the elements of the tooth-forming apparatus and are found exclusively within the jawbones. This review represents a contemporary outline of our current understanding of the molecular and genetic alterations associated with the development and progression of odontogenic tumors, including oncogenes, tumor-suppressor genes, oncoviruses, growth factors, telomerase, cell cycle regulators, apoptosis-related factors, regulators of tooth development, hard tissue-related proteins, cell adhesion molecules, matrix-degrading proteinases, angiogenic factors, and osteolytic cytokines. It is hoped that better understanding of related molecular mechanisms will help to predict the course of odontogenic tumors and lead to the development of new therapeutic concepts for their management.

Apoptosis↗
PubMed1986

Adenomatoid odontogenic tumor associated with calcifying epithelial odontogenic tumor.

A case of odontogenic tumor which contained areas diagnostic for both adenomatoid odontogenic tumor and calcifying epithelial odontogenic tumor arising in the upper left anterior region in a 17-year-old Japanese female is reported. The histopathological observation suggested that the lesion represented primarily adenomatoid odontogenic tumor in which multiple foci of calcifying epithelial odontogenic tumor had developed.

Adolescent↗
PubMed2003

[Adenomatoid odontogenic tumor in calcifying odontogenic cyst].

BACKGROUND: Adenomatoid odontogenic tumors (AOT) and calcifying odontogenic cysts (COC, Gorlin's cyst) are rare benign specificities of odontogenic tumors. Most odontogenic tumors are lesions of embryonic odontogenic tissue. Radiographically, odontogenic tumors may mimic an odontogenic follicular cyst. CASE REPORT: This paper describes the case of an 11-year-old female patient with a remarkable combination of these two entities. The lesions were found at the site of a retained first premolar and a persistent deciduous tooth 84 of the right lower jaw. Without clinical symptoms the tumor had expanded the vestibular cortical bone of the premolar region. Radiographically, the lesion appeared as a typical follicular cyst. During the operation, excochleation of the cyst was performed and the premolar was extracted. Finally, the epithelium of the cyst was treated by curettage. The histologic specimen revealed the diagnosis of an adenomatoid odontogenic tumor (AOT) in a calcifying odontogenic cyst (COC). DISCUSSION: The described case shows that symptoms of odontogenic tumors are usually nonspecific. For that reason one should always take a biopsy for histological investigation when patients present atypical cysts of the jaw. In rare cases even malignant odontogenic neoplasms could occur.

Bicuspid↗
PubMed1987

Odontogenic tumor with combined characteristics of adenomatoid odontogenic and calcifying epithelial odontogenic tumors.

A very rare odontogenic epithelial tumor with the combined characteristics of an adenomatoid odontogenic tumor (AOT) and calcifying epithelial odontogenic tumor (CEOT) was found in a 27 year old female. The histopathology, immunohistochemistry of keratin, lectin-binding patterns and distribution of carbonic anhydrase were determined. The nature of the calcified bodies was also examined biophysically. The tumor consisted of cuboidal and columnar odontogenic epithelial cells in the cystic wall, and AOT and CEOT in the central cavity. Odontogenic epithelial cells forming the cyst wall in the CEOT were positive for TK- and KL1-keratins, while that detected with PKK1 antibody was absent in the tumorous epithelium. Lectin binding of tumor epithelial cells was examined with Concanavalin A (Con A), peanut agglutinin (PNA), soybean agglutinin (SBA), dolichos biflorus agglutinin (DBA), wheat germ agglutinin (WGA), ricinus communis agglutinin (RCA-I), and ulex europeus agglutinin I (UEA-I) lectins, and the tumor epithelium indicated existence of glucose, mannose, Gal, GalNAc, and GlcNAc residues. The lectin binding patterns of the calcified material showed an increased intensity by enzymatic pretreatments. With an electron probe X-ray microanalyser (EPMA), the calcified lesions gave a high peak for calcium ion and for phosphorus ion and a low one for magnesium ion, as obtained from line and surface analysis.

Adult↗
PubMed2004

Hybrid odontogenic tumor of calcifying odontogenic cyst and ameloblastic fibroma.

Odontogenic tumors composed of 2 distinct types of lesions are unusual. We report an odontogenic tumor that was composed of calcifying odontogenic cyst and ameloblastic fibroma that occurred in the right posterior maxilla of a 22-year-old Korean woman. The tumor had a cystic component with an ameloblastic epithelial lining and conglomerates of so-called ghost cells, and there were deposits of dentinoid material adjacent to the cyst. These are features characteristic of calcifying odontogenic cyst. Enamel organ-like epithelial islands were observed within a dental papilla-like stroma of the cyst wall. Additionally, a solid portion of the tumor had characteristic features of ameloblastic fibroma, i.e., a myxoid cellular stroma with numerous elongated islands of ameloblastic epithelium. Ghost cell masses were found in the area of ameloblastic fibroma as well. The distribution of the ghost cells suggests that this is a hybrid lesion rather than a collision tumor.

Adult↗
PubMed1994

Limitation of panoramic radiography in diagnosing adenomatoid odontogenic tumors.

Adenomatoid odontogenic tumor is frequently not diagnosed preoperatively even when radiographs are available. This study evaluates radiographic findings with special emphasis on the characteristic radiopacities of adenomatoid odontogenic tumor. In correlating radiologic findings with pathologic findings, differences in diagnostic accuracy between intraoral periapical and panoramic radiographs were found. The intraoral periapical radiograph allows perception of the radiopacities in adenomatoid odontogenic tumor as discrete foci having a flocculent pattern within radiolucency even with minimal calcified deposits. Panoramic radiography was often unable to demonstrate radiopacities in adenomatoid odontogenic tumor when the calcification was minimal. The result indicates that intraoral radiographs may be essential for correct radiographic interpretation of an adenomatoid odontogenic tumor in the presence of minimal quantities of calcified deposits.

Adolescent↗
PubMed1986

Plexiform granular cell odontogenic tumor.

Two odontogenic tumors characterized by a previously undescribed histologic appearance are reported. Both lesions consisted of interlacing strands of odontogenic epithelium, with each strand being two cell layers thick. The cells were large and polyhedral in shape, with a granular eosinophilic cytoplasm. The nuclei were arranged "back to back" away from the basement membrane. One of the lesions seems to have originated, at least in part, from the basal layer of the oral epithelium. There is some evidence to suggest that these lesions may represent previously undescribed histologic variants of the ameloblastoma. However, the possibility that they represent a new entity cannot be excluded. For the time being the term plexiform granular cell odontogenic tumor is suggested.

Aged↗
PubMed1981

Squamous odontogenic tumor.

Squamous odontogenic tumors are rare benign neoplasms of the jaws that are thought to originate from remnants of the dental lamina. They have been confused with other lesions composes of nests of squamous epithelium including well-differentiated squamous carcinoma. The clinicopathologic features of two squamous odontogenic tumors are presented. The electron-microscopic appearance of one of these is described, and the 16 previously reported cases are reviewed.

Adolescent↗
PubMed1992

[Adenomatoid odontogenic tumor].

Adenomatoid odontogenic tumor is observed most frequently in male patients aged between 10 and 20 years. Occurring usually in the anterior part of the upper jaw, its discovery is often fortuitous during routine radiological examinations, which show a well defined clear zone 1 to 3 cm in diameter. Treatment by curettage results in healing by secondary bone cicatrization. A case is reported and epidemiological, clinical, diagnostic, therapeutic and prognostic features reviewed.

Adolescent↗
PubMedDate not supplied

Induction of osteodentin and abortive enamel in adenomatoid odontogenic tumor.

Adenomatoid odontogenic tumor (AOT) with induction of calcified dentin with or without concomitant formation of enamel is exceedingly rare. This paper reports a case of AOT showing induction of osteodentin and abortive enamel. The patient was a 15-year-old male with a well-circumscribed intraosseous lesion containing the crown of the embedded left maxillary canine. Histologically, induction of osteodentin and abortive enamel was seen, in addition to characteristic histological features of AOT. The review of the English literature yields that the present case is the second AOT with induction of both dentin and enamel.

Adolescent↗
PubMed2001

Immunohistochemical detection of amelogenin and cytokeratin 19 in epithelial odontogenic tumors.

OBJECTIVE: Epithelial odontogenic tumors exhibit considerable histological variation and are classified into several benign and malignant entities. Expression of amelogenin and cytokeratin 19 (CK19), that are potentially useful polypeptides for identification of odontogenic epithelial components, was evaluated in various types of epithelial odontogenic tumors. MATERIALS AND METHODS: Specimens of 33 ameloblastomas, three calcifying epithelial odontogenic tumors (CEOTs), two clear cell odontogenic tumors (CCOTs) and five malignant ameloblastomas were examined by immunohistochemistry using anti-amelogenin and anti-CK19 antibodies. RESULTS: Immunohistochemical reactivity for amelogenin was detected in many peripheral columnar or cuboidal cells and some central polyhedral cells in ameloblastomas, and histological variants showed various degrees of amelogenin expression. Expression of CK19 was diffusely present in neoplastic cells in ameloblastomas, and decreased expression was found in keratinizing cells of acanthomatous variants and some neoplastic cells of desmoplastic variants. In CEOTs, immunohistochemical reactivity for amelogenin was detected in neoplastic cells and intercellular amyloid-like materials, whereas CK19 was expressed in neoplastic cells. CCOTs showed positive reactivity for amelogenin and CK19 in neoplastic cells. Malignant ameloblastomas exhibited various degrees of amelogenin expression with constant CK19 expression in neoplastic cells. CONCLUSION: Diverse types of epithelial odontogenic tumors express amelogenin and CK19, suggesting that these tumors have ameloblastic differentiation or odontogenic epithelial properties.

Ameloblastoma↗
PubMed1977

[Frequency and differentiation of odontogenic tumors].

The odontogenic tumors stand for a group of lesions of a most interesting and fascinating kind. They represent mirror images of an uncontrolled odontogenesis. The insurmountable problems of insufficient knowledge of etiology, its exceptional rarity and diversity, as well as the lack of a generally accepted nomenclature and classification, defeat almost every attempt to gather and estimate clinical data of the various tumor forms. Considering these problems, various diagnostical criteria to deliminate each single tumor form have been valued and tabulated by means of statistical data, taken from world literature. Easily comprehensible clinical diagnosis, such as sex, age, location, and "characteristic" x-ray results have been valued and tabulated. From the variety of these most different classifications, being mentioned in a short historical survey, the "Histological Typing of Odontogenic Tumours, Jaw Cysts, and Allied Lesions", published by the WHO in 1971, has been chosen and taken as a basis. In addition to this rarely publicised data concerning the absolute and the relative frequency of these tumors have been compiled.

Adolescent↗
PubMed1993

Unusual granular cell odontogenic tumor. Report of two undescribed cases with features of granular cell ameloblastoma and plexiform granular cell odontogenic tumor.

Granular cell ameloblastoma (GCA) is a well recognized variant of follicular ameloblastoma with extensive granular cell change. In contrast, plexiform granular cell odontogenic tumor (PGCOT) is a rare and recently described lesion characterized histologically by a monophasic plexiform pattern of granular cells. In this paper, two cases of an unusual granular cell odontogenic tumor exhibiting combined features of these two entities are described along with their immunohistochemical characteristics. The granular cells of both the GCA and PGCOT areas showed similar patterns of expression for keratin and S-100, which differed from those of typical ameloblastoma. No reactivity for desmin or vimentin was noted. The histomorphologic and immunohistochemical features of these hybrid tumors suggest that the granular cells present have a common origin, most probably the odontogenic epithelium.

Adult↗