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At least 19 recordsLinked to original sources

Incidence of osteoperiostitis of the great toe in psoriatic arthritis.

OBJECTIVE: To assess the incidence of osteoperiostitis of the distal phalanx of the great toe in psoriatic arthritis (PsA). METHODS: One thousand great toes (202 of PsA, 44 of cutaneous psoriasis, 274 of low back pain patients, 296 of rheumatoid arthritis, 136 of spondyloarthropathy, and 48 of connective tissue diseases) were studied for osteoperiostitis of the distal phalanx of the great toe (slight, moderate, or severe), destructive joint lesions of the feet, nail dystrophy, fungal infection, and HLA-B type (patients with PsA). RESULTS: Osteoperiostitis was observed in 92 great toes. Moderate and severe osteoperiostitis were observed only in PsA. Osteoperiostitis was statistically more frequent in PsA (53/202, 26.2%, especially in those with onychosis: 20/41, 48.8%) than in other groups (39/798, 4.9%) (p < 0.01). In PsA, osteoperiostitis was more frequent in patients with nail dystrophy (20/41, 48.8%) than in patients without (33/161, 20.5%) (p < 0.05). Fungal infection of the nail and HLA haplotype were not associated with osteoperiostitis. In patients with PsA, osteoperiostitis was associated with destructive joint lesions of the feet. CONCLUSION: Osteoperiostitis of the distal phalanx of the great toe is an enthesopathy evocative of PsA.

Arthritis, Psoriatic↗

Vascularization of free periosteal and 100 micron thick osteoperiosteal grafts in muscle tissue environment.

The vascularization of free periosteal and 100 micron thick osteoperiosteal grafts was studied in growing rabbits. Sixteen rabbits with 32 periosteal and 32 osteoperiosteal grafts were operated upon and microangiographed 1-21 days postoperatively. The vascularization of free periosteal grafts started 1 day postoperatively and that of osteoperiosteal grafts 3 days postoperaitvely. The first capillaries seemed to enter through the cambium layer in periosteal grafts and through the cortex in osteoperiosteal grafts.

Angiography↗

Bone formation by vascularized periosteal and osteoperiosteal grafts. An experimental study in rats.

The osteogenic capacity of vascularized periosteal and osteoperiosteal grafts was investigated in 82 Wistar rats about 8 weeks old. The periosteal flaps, pedicled on the descending genicular artery, were taken by stripping the lower third of the femur. In the right hindleg, the grafts were made with periosteum only, while in the left hindleg, the periosteal flaps were associated with cancellous bone. The animals were divided into two groups of 41. In group I, both the periosteal and osteoperiosteal grafts were placed in contact with cortical bone, and in group II, the grafts were buried in muscle. Subgroups of 8 animals were killed after 1, 2, 4, 8, and 16 weeks postoperatively. The grafted region was evaluated radiographically, macroscopically, and histologically. Membranous ossification was the main source of bone formation. Osteoperiosteal grafts produced a greater amount of new bone than periosteal ones. There was evidence that the contact of the graft with living cortical bone favored bone formation.

Animals↗

The reverse flow medial knee osteoperiosteal flap for skeletal reconstruction of the leg. Description and anatomical basis.

A new, pedicled, reverse flow osteoperiosteal flap based on 2 branches of the descending genicular a. is presented. Both a periosteal and osteoperiosteal flap can be raised at the distal end of the femur and, in favourable cases (64% of the dissections), transported as far as the middle third of the leg. In all other cases the proximal third of the tibia can be reached. Composite musculo-osteoperiosteal flaps can also be raised, including the articularis genus m. Clinical applications may include the treatment of nonunions, reconstruction of segmental tibial defects and bone revascularisation in aseptic necrosis about the knee joint.

Aged↗

[External auditory canal reconstruction and mastoid cavity obliteration with composite multifractured osteoperiosteal flap: a preliminary study].

OBJECTIVES: Open cavity mastoidectomy techniques cause some cavity problems. We used inferior pedicled composite multifractured osteoperiosteal flap, which is our original surgical approach to obliterate the mastoid cavity, reconstruct the external auditory canal (EAC), and to prevent open cavity problems. PATIENTS AND METHODS: Composite multifractured osteoperiosteal flap was used to obliterate the mastoid cavity and reconstruct the EAC in four patients (2 females, 2 males; mean age 34; range 31 to 38 years) who previously underwent radical mastoidectomy to treat chronic otitis media with cholesteatoma. Small meatoplasty was applied in all the patients to relive their esthetical concerns. The patients were followed-up for two years. RESULTS: The epithelization of the new EAC was complete at the end of the second month. Cholesteatoma, granulation, or recurrence of osteitis did not occur in any of the patients. We detected new bone formation filling the mastoid cavity on postoperative temporal bone CT images. CONCLUSION: An almost natural EAC was obtained due to neo-osteogenesis that developed behind the composite multifractured osteoperiosteal flap.

Adult↗

Autoarthroplasty of knee cartilage defects by osteoperiosteal grafts.

Five fresh osteochondral fractures of the knee, which could not be fixed because of extensive fragmentation, were treated by excision of the fragments and reconstruction of the joint surface defect by an autogenous osteoperiosteal graft. The procedure was also used for joint surface reconstruction in sclerotic osteochondritis of the femoral condyle (nine knees) and grave patellofemoral chondromalacia (three knees). Plaster cast immobilization for 3 weeks was used in the two early cases. In all other cases, we employed a passive motion apparatus for 2 days postoperatively, followed by active mobilization in a knee brace with extension-flexion 30 to 90 degrees (femoral condyle reconstruction) or 0 to 45 degrees (patellar reconstruction). Gradual free movements were started 3 weeks postoperatively. The results after 1.5 to 6.5 years were satisfactory in all but one case. One arthroscopic removal of the loose graft was performed, as were two arthroscopic graft margin shavings. Three other reoperations were unrelated to the osteoperiosteal reconstruction. It appears that periosteal reconstruction should be considered in local osteochondral lesions, where excision of the injured cartilage is mandatory. The results were best in fresh trauma cases and younger people.

Adolescent↗

Carbon fibre reinforced epoxy implants for bridging large osteoperiosteal gaps.

An experimental study was undertaken to evaluate the suitability or otherwise of carbon fibre reinforced epoxy (CFRE) implants for bridging large osteoperiosteal gaps, devoid of periosteum. Using the basic principles of composite mechanics and simple design criteria, CFRE implants were designed and developed. These implants were put in simulated osteoperiosteal gaps in the ulna of healthy mature rabbits. Ten wk postoperative results clearly demonstrated that implants made of CFRE induced callus bone formation (in the form of woven bone) which totally encapsulated the implant thereby providing reunion of the two bone segments. Further follow-up showed formation of lamellar bones and formation in the pores of the implant. Radiological and scanning electron microscopical evidence is presented.

Animals↗

Contour and volume assessment of repairing mandibular osteoperiosteal continuity defects in sheep using recombinant human osteogenic protein 1.

BACKGROUND: This study describes the contour and volume of reconstructed mandibles using recombinant human osteogenic protein 1. MATERIAL AND METHODS: The investigation was conducted on six adult sheep, where a unilateral 35 mm parasymphyseal osteoperiosteal continuity defect of the mandible was created. Recombinant human osteogenic protein 1 and type-I collagen (as carrier) were applied to the defects. Radiographic and ultrasonographic examinations were carried out at day 1 of the surgery and 2, 4, 8, and 12 weeks following the surgery. The animals were then sacrificed 3 months after the operation. Postmortem CT-scan was performed for volumetric, cross-sectional area, height and width measurements. RESULTS: Ultrasound was more efficient than radiographs in demonstrating early callus formation at 2 weeks, while radiographic evidence of bone formation was consistently detectable only after 4 weeks. Using the combination of recombinant human osteogenic protein type 1 and type-I collagen resulted in twice the volume, cross-sectional surface area, and height when compared with those of the corresponding region of the contra-lateral non-operated side of the mandible. CONCLUSION: Within 3 months, recombinant human osteogenic protein type 1 on type-I collagen carrier failed to restore the original contour and volume of mandibular osteoperiosteal continuity defects.

Animals↗

Stimulated osteoperiosteal pedicle grafts in dogs.

This descriptive study compared the healing of mucoperiosteal and "stimulated" osteoperiosteal flaps for the treatment of surgically created periodontal recessions in dogs. Surgically created defects on the canine teeth of 10 healthy mongrel dogs were covered by specially designed, cemented copper bands for 4 weeks (Several maxillary premolar teeth were managed in the same way). A plaque and calculus-promoting diet was fed to the animals during this period. When the bands were removed the diet was altered and an intensive oral hygiene program was instituted. The contralateral tooth, chosen randomly, was utilized for placement of the mucoperiosteal lateral sliding flap and acted as the control. The experimental side was surgically stimulated 21 days prior to elevation of a "stimulated" osteoperiosteal flap for repositioning over the denuded roots. The animals were sacrificed with an overdose of Nembutal and block sections for histologic study were taken at periods ranging from 14 to 50 days. Histologic findings indicate that healing of the stimulated flaps was accompanied by the formation of a relatively short dentogingival epithelium, cementogenesis which varied in amount and type, and new connective fiber insertion into cementum. By contrast, the mucoperiosteal flaps healed with a long dentogingival epithelial relationship and no cementogenesis or connective tissue reattachment.

Alveolar Process↗

The repair of major osteochondral defects in joint surfaces by neochondrogenesis with autogenous osteoperiosteal grafts stimulated by continuous passive motion. An experimental investigation in the rabbit.

The purpose of this investigation was to determine the effects of continuous passive motion (CPM) on the chondrogenic potential of autogenous osteoperiosteal grafts to repair major osteochondral defects. A 3.5-mm-wide circular full-thickness defect was drilled in one medial femoral condyle of 55 adolescent New Zealand rabbits. A graft of periosteum from the proximal tibia was wrapped around a disc of bone from the same area (cambium layer of the periosteum facing outward), then press-fitted into the defect. The rabbits were treated by either immobilization (Imm) or intermittent active motion (IAM) for five weeks, or by continuous passive motion (CPM) for two weeks followed by IAM for three weeks. A control group (no osteoperiosteal graft in the defect) was also treated by CPM for two weeks and IAM for three weeks. At five weeks, hyaline cartilage was the predominant tissue in only 10% of the defects in the Imm, IAM, and control groups, compared with 70% in the CPM group (p less than .025). Bonding of the newly formed tissue to the adjacent cartilage was significantly better in the CPM group.

Animals↗

The bridging of large osteoperiosteal gaps using 'Decalbone'.

'Decalbone' was prepared by partial decalcification of human bones obtained from recently amputated specimens. It was then stored in 80 to 90% ethanol in a domestic refrigerator. The decalbone was used to fill large osteoperiosteal gaps in 25 patients. The commonest lesion was a giant cell tumour (21 cases) and various long bones were affected. There were 6 failures with recurrence of the tumour in 3 and uncontrolled infection in 3. The remaining 19 cases were followed up for from 2 1/2 to 7 years. In 10 the decalbone incorporated well, but further reconstructive procedures were needed in 9. Our studies showed that incorporation began at around 6 to 9 months and was complete at about 2 years in the upper limb and 4 years in the lower limb. There was no clinical evidence of an immune response.

Adult↗

Canal wall reconstruction and mastoid obliteration with composite multi-fractured osteoperiosteal flap.

We used inferior pedicled composite multi-fractured osteoperiosteal flap (CMOF), our original and new surgical approach, to obliterate the mastoid cavity and reconstruct the external auditory canal (EAC) to prevent the open cavity problems. CMOF was used to obliterate the mastoid cavity and reconstruct the EAC in 24 patients (13 women, 11 men; age span 12-51 years) who underwent radical mastoidectomy to treat the chronic otitis media between 1998 and 2004. Small meatoplasty was done in all 24 patients to relieve their aesthetical concerns. Temporal bone CT scanning was done to observe the neo-osteogenesis in the mastoidectomy cavity and the CMOF, and the EAC volume was measured postoperatively. All our patients were followed-up for 2 years. The epithelization of the new EAC in our patients was complete at the end of the second month. Cholesteatoma, granulation, and recurrence of osteitis did not occur in any of the patients. We saw the new bone formation filling the mastoid cavity in the postoperative temporal bone CT scanning images. The mean volume of the new EAC on the 24th month was 1.83 +/- 0.56 cm(3). We had an almost natural EAC, which owed its existence to the neo-osteogenesis that grows behind the CMOF, which we use to obliterate the mastoid cavity and to reconstruct the EAC.

Adolescent↗

Histological assessment of bioengineered new bone in repairing osteoperiosteal mandibular defects in sheep using recombinant human bone morphogenetic protein-7.

UNLABELLED: Numerous experimental studies have been published about osteoinductive bone morphogenetic proteins (BMPs). However, to our knowledge there has been no detailed histological study of a mandibular defect in a large mammal, reconstructed using BMPs. We describe here the histological features of rhBMP-7-induced bone in mandibular defects in sheep. METHODS: A 35 mm osteoperiosteal defect was created at the parasymphyseal region of the mandible in six adult sheep. The continuity of the mandible was maintained using a bony plate, and rhBMP-7 was applied on a type I collagen carrier. Bone labels were injected at selected time intervals during the follow-up period. The animals were killed after 3 months and bone samples were examined histologically, histomorphometrically, and by fluorescence microscopy. RESULTS AND CONCLUSIONS: We found a mixture of woven and lamellar bone that contained many cells with large nuclei. This had not reorganised to form cortical bone and the rhBMP-7-induced bone was more porous than the native bone. The newly-formed bone restored both endosteal and periosteal layers. rhBMP-7-induced bone was biocompatible and induced no ossification of soft tissue or abnormal growth of nearby vital structures. The mineral apposition rate was 1.98 microm/day (range 0.62-5.63 microm/day), a value close to that reported in humans. This suggests that BMPs have a limited effect in accelerating the rate of mineralisation, but promote the pre-mineralisation processes, and perhaps the formation of woven bone.

Animals↗

Bridging of large chronic osteoperiosteal gaps by allogeneic decalcified bone matrix implants in rabbits.

A circumferential complete osteoperiosteal gap (1 to 1.5 cm) was produced in the diaphysis of ulna of rabbits, and the ipsilateral radius was kept intact. In no case did spontaneous bridging of the gap occur. By 6 weeks after the creation of the gap the bone ends became smooth and tapered towards the ipsilateral radius and the defect was observed to be filled by thin fibrous tissue. Established defects at least 6 weeks old were then bridged by inserting a snugly fitting allogeneic bone matrix implant. The bone matrix was prepared by demineralization of tubular bones from healthy rabbits, using 0.6 M HCl, preserved in 75% alcohol and used within 3 weeks. The fate of the implant was observed clinically, radiologically, histologically by tetracycline fluorescence for up to 12 weeks. Radiologic evidence of bone formation was present in a majority by 6 weeks, and complete bridging of the gap was seen in 75% of cases by 12 weeks after implantation. Most of the initial bone that formed was the woven bone, i.e., immature bone formed directly from the mesenchymal cells, or formed in membrane, though areas of enchondral ossification were also observed in some cases. By 12 weeks, the bone had remodeled almost to the texture of a mature tubular bone. Successful bridging of chronic massive bone defects by allogeneic bone-matrix was confirmed in 75% of cases.

Animals↗

Treatment of lumbar lytic spondylolisthesis using osteoperiosteal transplants in young patients.

A series of 40 young patients with lumbar spondylolisthesis is presented. The patients were treated surgically using osteoperiosteal transplants as the fusion material. In 29 patients, the fusion was posterior and in 11 patients posterolateral. The loose posterior element was removed in eight patients in connection with fusion. The degree of slipping on admission was less than 30% in 18 patients (45%), 30 to 50% in 5 patients (12.5%), and more than half of the olisthetic vertebral body in 17 patients (42.5%). A good clinical result was obtained in 24 patients (60%), satisfactory in 11 (27.5%), and poor in 5 (12.5%). Solid union was obtained in 29 patients (72.5%), nonunion in 7 cases (17.5%), and in 4 patients (10%) the union was considered uncertain. One patient was reoperated on. The best results were obtained using posterior fusion, while the rate of nonunion was higher in the posterolateral group. The periosteum was taken from the anteromedial aspect of the tibia using a sharp chisel. The method gives clinical and radiological results comparable with those obtained using bone transplants.

Adolescent↗

Osteoperiosteal flap in the treatment of ozena. New technique.

An osteoperiosteal flap taken from the anterior wall of the maxilla and pedicled on its periosteum was developed to narrow the nasal cavity of 15 patients with ozena. Good results were obtained in over 80% of cases. Crusting, fetor, and epistaxis disappeared. The nasal mucosa appeared healthy. The bulge in the lateral nasal wall persisted. The method is not liable to graft rejection or shrinkage. The advantages of this new technique are discussed.

Adolescent↗

Laterally repositioned "stimulated" osteoperiosteal pedicle grafts in the treatment of denuded roots. A preliminary report.

In order for successful coverage of denuded roots to be accomplished, correctly applied fundamental biological principles must be considered in the choice and utilization of the surgical modality. In this report some representative clinical cases are presented to indicate favorable results that may be achieved with stimulated osteoperiosteal pedicle flaps. These cases are part of an ongoing clinical and statistical evaluation.

Gingiva↗

The osteogenic capacity of free periosteal and osteoperiosteal grafts. A comparative study in growing rabbits.

The behaviour of free periosteal and 200 micron thick osteoperiosteal grafts was studied histologically in 40 six-week-old rabbits. The grafts were taken from the tibia and fixed on either side of the same lumbar vertebra between the spinous and mamillary processes. The free stripped periosteum had better osteogenic activity than the 200 micron thick osteoperiosteum. The new bone was formed by the osteogenic cells of the cambium layer in both types of graft.

Age Factors↗