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At least 19 recordsLinked to original sources
PubMed1985

[The effect of oxedrine on the left ventricle and peripheral vascular resistance].

The sympathomimetic substance oxedrine (Sympatol) influences, by means of its affinity to alpha- and beta-receptors, cardiac performance and peripheral vascular tone. We studied in 12 healthy male volunteers the influence of intravenous oxedrine on left ventricular contractility parameters as estimated by TM-echocardiography, on cardiac index as well as on arterial blood pressure and peripheral vascular resistance. Under continuous intravenous infusion of 4 mg/min oxedrine the systolic and mean arterial blood pressure increased significantly (p less than 0.005) while the diastolic pressure and heart rate remained unchanged. The cardiac index increased (p less than 0.001) and the peripheral vascular resistance decreased significantly (p less than 0.01). The echocardiographically determined left ventricular contractility parameters, i.e. systolic shortening fraction (SF) as well as maximal velocity of shortening of the left ventricular diameter (VCFmin) also increased significantly (p less than 0.001 and 0.005, resp.). An increase in left ventricular contractility and cardiac index with concomitant decrease of peripheral vascular resistance and without increase in heart rate implies an economical increase in cardiac performance under intravenous infusion of oxedrine.

Adult↗
PubMed2007

Detection and validated quantification of nine herbal phenalkylamines and methcathinone in human blood plasma by LC-MS/MS with electrospray ionization.

The herbal stimulants Ephedra species, Catha edulis (khat), and Lophophora williamsii (peyote) have been abused for a long time. In recent years, the herbal drug market has grown owing to publicity on the Internet. Some ingredients of these plants are also ingredients of cold remedies. The aim of the presented study is to develop a multianalyte procedure for detection and validated quantification of the phenalkylamines ephedrine, pseudoephedrine, norephedrine, norpseudoephedrine, methylephedrine, methylpseudoephedrine, cathinone, mescaline, synephrine (oxedrine), and methcathinone in plasma. After mixed-mode solid-phase extraction of 1 ml of plasma, the analytes were separated using a strong cation exchange separation column and gradient elution. They were detected using a Q-Trap LC-ESI-MS/MS system (MRM mode). Calibration curves were used for quantification using norephedrine-d3, ephedrine-d3, and mescaline-d9 as internal standards. The method was validated according to international guidelines. The assay was selective for the tested compounds. It was linear from 10 to 1000 ng/ml for all analytes. The recoveries were generally higher than 70%. Accuracy ranged from - 0.8 to 20.0%, repeatability from 2.5 to 12.3%, and intermediate precision from 4.6 to 20.0%. The lower limit of quantification was 10 ng/ml for all analytes. No instability was observed after repeated freezing and thawing or in processed samples. The applicability of the assay was tested by analysis of authentic plasma samples after ingestion of different cold medications containing ephedrine or pseudoephedrine, and after ingestion of an aqueous extract of Herba Ephedra. After ingestion of the cold medications, only the corresponding single alkaloids were detected in human plasma, whereas after ingestion of the herb extract, all six ephedrines contained in the plant were detected. The presented LC-MS/MS assay was found applicable for sensitive detection and accurate and precise quantification of all studied analytes in plasma.

Chromatography, High Pressure Liquid↗
PubMed2004

Citrus aurantium, an ingredient of dietary supplements marketed for weight loss: current status of clinical and basic research.

Seville orange (Citrus aurantium) extracts are being marketed as a safe alternative to ephedra in herbal weight-loss products, but C. aurantium may also have the potential to cause adverse health effects. C. aurantium contains synephrine (oxedrine), which is structurally similar to epinephrine. Although no adverse events have been associated with ingestion of C. aurantium products thus far, synephrine increases blood pressure in humans and other species, and has the potential to increase cardiovascular events. Additionally, C. aurantium contains 6',7'-dihydroxybergamottin and bergapten, both of which inhibit cytochrome P450-3A, and would be expected to increase serum levels of many drugs. There is little evidence that products containing C. aurantium are an effective aid to weight loss. Synephrine has lipolytic effects in human fat cells only at high doses, and octopamine does not have lipolytic effects in human adipocytes.

Animals↗
PubMed1986

Repetitive bleeding from a pheochromocytoma presenting as an abdominal emergency. Case report.

Recurrent abdominal pain was the only subjective manifestation in a case of pheochromocytoma with retroperitoneal bleeding. At emergency laparotomy the tumor, showing signs of fresh and earlier bleeding, was extirpated. Sinus-type tachycardia was treated with beta-blockade peroperatively, while the diagnosis was still obscure, but hypertension did not follow. Meta-oxedrine and dopamine infusion was continued for 48 hours to sustain the blood pressure. Recovery was uneventful.

Abdomen, Acute↗
PubMed1993

[The effect of ascorbic acid on adrenergic lipolysis].

The effect of ascorbic acid on basal and adrenergic lipolysis was studied in rat epididymal adipose tissue in vitro. When adipose tissue was incubated with isoprenaline (ISO) for 1.5 h, the concentration-lipolytic effect curves of ISO were practically the same in the presence or absence of ascorbic acid used in concentration 100 and 1000 micrograms/ml. The lipolytic effect of ISO was not substantially altered even in the experiments in which adipose tissue was incubated with ISO for 4.5 h, but ascorbic acid (1000 micrograms/ml) was added only 1.5 h before the end of incubation. On the other hand, the contact of adipose tissue for 4.5 h with high concentration of ascorbic acid (1000 micrograms/ml) induced significant decrease of maximum adipokinetic effect of ISO. Contrary to catecholamine stimulated lipolysis, the basal rate of lipolysis was enhanced by ascorbic acid. Inhibition of maximum lipolytic effect of catecholamines (isoprenaline and noradrenaline-NOR) and oxedrine (isopropylnoroxedrine) was also seen when adrenomimetics were added to incubation medium 1.5 h before the end of 4.5 h incubation of adipose tissue with ascorbic acid. Decreased reactivity of adipose tissue to catecholamines persisted when the tissue, after 3 h incubation with ascorbic, was transferred into fresh medium with ISO and ascorbic acid. Preincubation of ascorbic acid (3h) in the incubation medium without adipose tissue, followed by subsequent addition of the tissue and catecholamines (NOR, ISO) and 1.5 h lasting incubation, did not influence the adipokinetic effect of NOR and ISO. These facts indicate that ascorbic acid decreases the lipolytic effect of catecholamines as a result of its effect on adipose tissue but not on the incubation medium.(ABSTRACT TRUNCATED AT 250 WORDS)

Adipose Tissue↗
PubMed1964

LEAKAGE OF TRANSMITTERS IN SALIVARY GLANDS.

Salivary secretion evoked by sympathetic stimulation or by injection of guanethidine, adrenaline or synephrine is slightly reduced by parasympathetic antagonists in doses which abolish the secretory responses to stimulation of the parasympathetic nerve. Similarly, an adrenaline antagonist caused a small diminution of the salivary flow elicited by parasympathetic stimulation or by injection of methacholine chloride. Secretion caused by pilocarpine could be accelerated by physostigmine. We conclude that transmitter leaks in subliminal concentrations, as far as secretion is concerned, from the sympathetic and parasympathetic postganglionic nerve endings.

Acetylcholine↗
PubMed1963

Enzymatic formations of adrenaline and other catechols from monophenols.

An enzyme that forms adrenaline from p- and m-sympathol and dopamine from p- and m-tyramine is localized in the microsomes of rabbit liver and requires the reduced form of nicotinamide adenine dinucleotide phosphate. The enzyme is nonspecific and can form catechols from the following normally occurring and foreign phenols: p- and m-octopamine, p-hydroxyephedrine, phenol, stilbestrol, N-acetyl-p-aminophenol, estradiol and N-acetylserotonin.

Animals↗