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At least 19 recordsLinked to original sources
PubMed1994

Confirmation study, using nitrobenzene, of the Combined Repeat Dose and Reproductive/Developmental Toxicity Test protocol proposed by the Organization for Economic Cooperation and Development (OECD).

A confirmatory familiarization study of the Combined Repeat Dose and Reproductive/Developmental Toxicity Screening (ReproTox) test protocol proposed by the Organization for Economic Cooperation and Development (OECD) was performed using nitrobenzene, a testicular toxicant. The agent was given daily by gavage to groups of 10 male and 10 female Sprague-Dawley rats at doses of 100, 60, 20 and 0 mg/kg body weight. Some of the high dose animals exhibited neurological signs, and two males and 9 females died. Hemolytic anemia due to methemoglobin formation was evident in treated males. Histopathologically, treated males showed atrophy of seminiferous tubules of the testis, reactive changes secondary to hemolytic anemia in the hematopoietic organs, and hepatocellular swelling. Cerebral gliosis was observed in middle and high dose males. Male fertility was not affected. The body weights of pups from treated dams were lowered, and their postnatal loss was increased. Most of the known toxicological properties of this chemical was demonstrated in the present study, with the exception of reduced fertility. Therefore, the ReproTox protocol was concluded as being useful as a screening test of existing high production volume chemicals. It should be noted that while the reproductive toxicity test alone is insensitive for detection of male fertility disturbances associated with testicular toxicity, the latter easily be distinguished on morphological grounds.

Animals↗
PubMed1995

The distribution of "big ticket" medical technologies in OECD countries. Organization for Economic Cooperation and Development.

Five "big ticket" medical technologies (BTTs) in 1990 were compared in the 24 OECD countries in relation to population, the number of physicians, gross domestic product (GDP), and health care expenditures (HCE). Wide variations were observed between and within countries for all measures. Regression analysis revealed that HCE explains part of the variation in the distribution of computed tomography scanners (excluding Japan), magnetic resonance imaging units, and radiation therapy units (R2 between 0.40 and 0.69), but not extracorporeal shock wave lithotripters. To a lesser extent, GDP was also found to correlate with the distribution of these technologies, but no correlation was found with number of physicians. Other factors affecting the diffusion of these technologies are proposed for study.

Developed Countries↗
PubMed1994

Health system performance in OECD countries, 1980-1992. Organization for Economic Cooperation and Development.

U.S. health expenditure levels and rates of increase continue to exceed those of other Western industrialized nations. The pluralistic U.S. health care system has the highest excess health care inflation and opportunity costs of forgone nonhealth consumption and investment when compared with other major industrialized countries. While poor U.S. performance in terms of life expectancy at birth and infant mortality may partially result from social problems, there is little quantifiable evidence of value for money or equity in terms of health system performance.

Europe↗
PubMed1984

Biodegradation of 4-nitrophenol in standardized aquatic degradation tests.

During the years 1978-1981 both the European Economic Community (the EEC) and the Organization for Economic Cooperation and Development (the OECD) organized various interlaboratory comparison programs on standardized screening methods to study the biodegradability of chemicals in water. While the ring test results were generally rather heterogenous, one of the compounds studied, 4-nitrophenol, turned out to be particularly problematic as the compound was found either easily biodegradable or not biodegradable by various laboratories in various tests. This paper describes some more detailed studies on 4-nitrophenol degradation in two different tests, the modified OECD screening test (MOST test) and the Zahn-Wellens test, respectively. The test variables investigated include inoculum characteristics and pretreatment, test duration, and 4-nitrophenol concentration. The results are discussed in relation to toxicity and degradation pathways of 4-nitrophenol. It is concluded that in order to improve the comparability of results from standardized aquatic biodegradation tests, test strategies should allow the option of performing a test with a preadapted inoculum in the event of negative test results with freshly collected inocula. Increasing the inoculated concentration of microorganisms in some tests may also contribute to the attainment of more consistent test results.

Biodegradation, Environmental↗
PubMed1998

Health observation and health reporting in Europe.

The need and demand for comparable comprehensive health data and health information is growing in Europe. Many countries have intensified development of their health information systems and health reporting. The World Health Organization (WHO), the Organization for Economic Cooperation and Development (OECD) and other international organizations collect health data and publish comparative health reports. The European Union (EU) has initiated several new activities to improve health statistics and to develop health monitoring. Sometimes they overlap with other international activities. Also, EU Agencies have been set up in several health related fields. EU public health programmes on specified health problems also monitor health. The Health Monitoring Programme (HMP) adopted in 1997 is intended to pave the way for permanent EU health monitoring. After an unfortunate delay, the first HMP decisions to fund projects were made in July 1998. A feasibility analysis resulting in proposals for the organization of EU health monitoring was carried out in 1997. Other recent developments in the EU are the establishment of a communicable disease network, and the Commission's communication on future public health policy. The Amsterdam Treaty attaches more importance to public health. Much work needs to be done before a coherent EU health monitoring system can be put in place. The current momentum must be used to speed up positive developments. The HMP should support projects which pave the way for permanent EU health monitoring and its work should be clearly prioritised. Also, the expertise in health monitoring and the ability to steer the HMP and related EU developments should be strengthened. This can best be done by close collaboration with experienced expert institutes from the Member States, and by collaboration with WHO and OECD.

Europe↗
PubMed1997

Productivity growth in health-care delivery.

OBJECTIVES: The authors compute and compare productivity growth in the health-care sectors for a sample of Organization for Economic Cooperation and Development countries over the period from 1974 to 1989. The authors compute Malmquist productivity indexes, which allow productivity growth to be decomposed into efficiency changes and technical change. These indexes also allow the use of primary quantity data (recently available from the Organization for Economic Cooperation and Development), rather than expenditure data, which the authors argue reduces bias resulting from distorted prices. METHODS: The authors specify two models. The first model focuses on the hospital sector; inputs include physicians and medical care beds, whereas outputs are the "intermediate" type used in hospital efficiency studies, namely, inpatient days and discharges. RESULTS: For the 19 countries with complete data, the authors found little productivity growth based on this model (with the exception of Denmark, with 15.4% cumulated growth, and the United States, with about 5% from 1974 to 1989). The authors did find, however, that the highest productivity levels are found in the United States (Italy and Finland were also on the frontier of technology in the base period, 1974). The second model uses the same inputs as the first (but in per capita terms), but it specifies simple proxies of health outcomes as outputs: life expectancy of women at age 40 and the reciprocal of the infant mortality rate. CONCLUSIONS: For the 10 countries with complete data for this model, the authors found evidence of much more widespread and rapid productivity growth: Denmark's cumulated growth was close to 33%, with the United States close behind. In both these countries, this growth was due solely to technical change over this period.

Canada↗
PubMed1998

Suicidal behavior in a bicultural society: a review of gender and cultural differences in adolescents and young persons of Aotearoa/New Zealand.

During the 1990s, Aotearoa/New Zealand has experienced an alarming increase in youth suicide in the Maori and non-Maori populations. Among 23 Organization for Economic Cooperation and Development countries surveyed by the World Health Organization's (1995) World Health Statistics Annual, New Zealand ranks first for fatal suicidal behavior, in males 15-24 years of age, and third for fatal suicidal behavior in females. A United Nations Children's Fund (UNICEF, 1996) survey of 32 countries places New Zealand males as third highest for fatal suicidal behavior, and females as eighth highest in the age group 15-24 years. New Zealand has recently undergone a number of social and economic changes that have created dramatic social and cultural shifts. Given the rapidity of these changes, the shock on such a small country has been difficult to absorb. These shifts have placed tremendous pressures on families and service support systems, such as health and mental health services, to develop programs that are relevant and acceptable for a bicultural society. This article focuses on these changes and the effect they have had on cultural narratives of gender and suicidal behavior, the different cultural etiologies that underlie these statistics, and recommendations for intervention and prevention program development.

Adolescent↗
PubMed1980

The influence of the sulphonic group on the biodegradability of n-alkylbenzene sulphonates.

1. Model compounds of the type p-n-alkylbenzene sulphonates, p-n-alkylbenzoic acids and phenylcarboxylic acids were tested for biodegradability. Bioassays were performed with unadapted mixed cultures (soil suspensions) using the Organization for Economic Cooperation and Development (OECD) screening test. 2. Degradation was measured by dissolved organic carbon analysis and g.l.c. or h.p.l.c. 3. p-n-Alkylbenzene sulphonates were resistant to microbial attack. The carboxylated compounds with analogous structures, however, with one exception, were easily decomposed. 4. The results indicate that the persistent character of p-n-alkylbenzene sulphonates is mainly due to the sulphonic substituent.

Bacteria↗
PubMed1992

Road traffic accidents in Nigeria: a review and a reappraisal.

Based on data that are at best conservative estimates, Nigeria is a country with a serious and growing road accident problem that is about the worst in the world. As can be seen from the trend over a 15-year period (1971-1985), legislative and other countermeasures thus far have proved ineffective. In 1988, a new approach was adopted with the formation of a national body charged with road traffic accident control--The Federal Road Safety Commission. In this paper, the programme of action of this body is examined to see to what extent it hopes to be able to fulfil its mandate. Suggestions are made on how the motorized industrialised countries can give assistance to developing countries through such bodies as the World Health Organization (WHO), the Organization for Economic Cooperation and Development (OECD), and the World Bank.

Accident Prevention↗
PubMedDate not supplied

[Evolution of air pollution and impact on control programs in 3 megacities in Latin America].

The present work discusses the problems of atmospheric pollution of three Megacities of Latin America (Mexico City, Sao Paulo and Santiago). The environmental pollution control programs implemented by the Government are revised and the evolution of pollution levels during the period of 1988-1995 at Santiago de Chile and Sao Paulo, but until 1997 at Mexico City, in order to evaluate the impact of these programs. During this period, a decreasing trend is observed in the three cities in the levels of PTS, PM10, SO2, NO2, CO and O3, although most of these contaminants still exceed the air quality standards. It must be emphasized that the largest impact has been on the levels of SO2. We recommend the development of sustainable transport policies; in this context, various strategies were proposed by the Organization for Economic Cooperation and Development (OECD) in the European Conference of Ministers of Transport. Additionally, public participation is important when decisions are taken on transport policies.

Air Pollution↗
PubMed1997

Potency grading in carcinogen classification.

In 1992 the United Nations Conference on Environment and Development decided to harmonize carcinogen classification systems. A proposal for a harmonized classification system is currently being considered by the Organization for Economic Cooperation and Development (OECD). In many countries, classification of a chemical as carcinogenic triggers labeling requirements. Implicit in the labeling requirements are often restrictions on the sale of consumer products and workplace regulations. Many of the current classification systems for carcinogens use a single concentration limit for the minimum concentration of a carcinogen in a preparation (mixture) that requires labeling. For high-potency carcinogens, one concentration limit may not adequately express the hazard, whereas for low-potency carcinogens, one limit may overestimate the hazard caused by the carcinogen in the preparation (mixture). The potency grading system discussed consists of three potency groups: high-, medium-, and low-potency carcinogens. It is envisioned that the different classes will trigger different labeling requirements. In the process of potency grading, a preliminary conclusion as to whether a substance shows high, medium, or low potency is initially based on a tumorigenic dose descriptor. The preliminary potency evaluation may then be modified after due consideration of a number of additional elements. These may include evaluation of the dose-response curve; site-, species-, strain-, and sex-specific activity; mechanisms including genotoxicity; mechanistic relevance to humans; toxicokinetics; and other factors. The potency grading system discussed is applicable to most carcinogen classification systems, including that currently being considered by the OECD.

Animals↗
PubMed1993

Effects of bis(tri-n-butyltin)oxide in Japanese quail exposed during egg laying period: an interlaboratory comparison study.

The guideline no. 206 for testing of chemicals of the Organization for Economic Cooperation and Development (OECD) comprising an avian reproduction test using the Japanese quail (Coturnix coturnix japonica; Termminck and Schlegel 1849) as pair-hold test organisms has been applied in a version that reduced the treatment period to 6 weeks without any pretreatment. In the present study bis(tri-n-butyltin)oxide, C.A. No. 56-35-9 (tributyltin oxide, TBTO) was examined by five participants in an interlaboratory comparison test. A comparable regimen of dosing was performed by all participants starting either with 24 or 60 mg/kg TBTO in the feed and ending with 150 or 375 mg/kg. Within this dose range no signs of toxicity in adults were observed. Substance-related effects however were obvious with regard to egg production, fertility, hatching success, and survival of 14 day-old chicks. A clear dose dependency was given regarding effects on egg weight and on hatchability. The no-observed-effect concentrations for these two parameters was 60 mg/kg TBTO, characterizing these parameters as the most sensitive in this investigation. With the presented set of test parameters further aspects of subchronic toxicity in adults and chicks can be assessed as well as the validity of the performed test. Comparing the results for most test parameters consistency is obvious, thus confirming the applicability of the presented test guideline.

Animals↗
PubMed1999

Health insurance and productivity.

AIM: To provide a conceptual understanding of the basic relationship between health insurance and overall economic productivity, and to look at the human development index as a proxy for the quality of human capital. METHODS: Economic data and data related to human development in Central and Eastern European (CEE) countries, including Croatia, were compared to the European Union (EU) average. Data were selected out of databases provided by the International Monetary Fund, the Organization for Economic Cooperation and Development, and the United Nations. Income and growth rates were related to the EU averages. The human development index was used to compare the level of the average achievements in the longevity of life, knowledge, and quality of living in CEE countries. RESULTS: Relative to the EU-average, human development is lagging behind in CEE countries. Considering the world as a benchmark regarding human development, 8 out of 13 CEE countries exceed the world. However, all CEE countries have 3-28% lower human development than the industrialized countries. CONCLUSIONS: The specific challenge for transition countries is how to adopt strategies to translate economic progress into health and social gains through reliable institutions, among them social health insurance bodies. The institutions and the provision of social health insurance are particularly challenged at a turning point when transition in terms of macroeconomic stabilization, along with the consolidated organization and financing of social and health insurance schemes, is accommodated to a business cycle-driven market economy.

Economics↗
PubMed1997

Health care spending, delivery, and outcome in developed countries: a cross-national comparison.

This study examines the trend of health care spending, availability and use of medical services, and aggregate health outcome of the 24 industrialized member countries of the Organization for Economic Cooperation and Development (OECD). Major differences between the United States and other OECD countries are highlighted and discussed. The results of the study demonstrate that, over the past four decades, the United States has been spending more and accomplishing less when compared with other industrialized nations. The United States needs to learn from the successful experience of other nations. Redesigning the system of health care delivery in the United States may be the only viable option to improve the quality of health care.

Aged↗