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PubMed2026

Influence of nicotine on protein expression around hydrophilic osseointegrated implants: A proteomic study in male rats.

OBJECTIVE: To ensure the success of dental implant treatment, various factors must be considered, including osseointegration and systemic conditions. There is evidence in the literature that smokers may exhibit alterations in tissue healing, which can compromise the success of implant rehabilitation. Therefore, this study aimed to investigate the influence of nicotine on the protein profile of bone tissue around hydrophilic implants during the osseointegration process in rats. DESIGN: Bone tissue samples from the control and nicotine groups (n = 3 per group) were subjected to protein extraction, mass spectrometry, and bioinformatic analyses. Protein identification was performed using Proteome Discoverer 2.1 software and the SEQUEST algorithm, and the protein data were compared with those of a protein database of Rattus norvegicus obtained from UniProt. RESULTS: A total of 740 proteins were detected in both the control group and the nicotine-exposed group. Among them, the proteins biglycan, periostin and histone H4 were highlighted because of their higher abundance in the healthy implant group, while they were reduced in the nicotine-exposed group. CONCLUSIONS: Nicotine has the potential to alter the protein profile of bone tissue around hydrophilic implants during osseointegration, which may impair tissue remodeling and healing.

Animals↗
PubMed1979

Functional state, bite force and postural muscle activity in patients with osseointegrated oral implant bridges.

The function of the masticatory system of 13 women, aged 42-59 years, with osseointegrated oral implant bridges (OIB) made within the last seven years was compared with that of 10 matched dentate controls by means of a questionnaire, clinical examination, bite force measurements and electromyographic recordings of biting and of postural muscle activity. Both groups were satisfied with their masticatory capacity according to the questionnaire. The clinically determined state of the masticatory system, as judged from the clinical dysfunction index, was normal in both groups. Three levels of bite force 1) gentle biting, 2) biting as when chewing and 3) maximal biting, were recorded with a bite force apparatus and electromyographically. There was no statistically significant difference between the groups at any level of bite force for any of the methods of registration. Nor was there any difference of the two groups in the activity of the masticatory muscles with the mandible in the postural position. It is concluded that patients with osseointegrated oral implant bridges have a masticatory muscle function equal to or approaching that of patients with natural teeth, or with tooth-supported bridges, with the same number of chewing units as the OIB-patients.

Adult↗
PubMed1979

Muscle function during chewing and swallowing in patients with osseointegrated oral implant bridges. An electromyographic study.

The activity of the anterior and posterior portions of the temporal muscle, the masseter and the upper lip has been studied with electromyography in 13 women with osseointegrated oral implant bridges and compared with that in 10 subjects with natural teeth. The functions examined were chewing and swallowing of apple, bread and peanuts. There was no difference between implant and control subjects in the number of chewing cycles nor in duration of the act of chewing or in the amplitude of the muscle activity during chewing and swallowing. However, the duration of the activity during chewing was longer in the implant than in the control subjects. The number of years of wearing a maxillary implant bridge was found to be of importance for the number of chewing cycles during an act of chewing and for the muscle activity during chewing. Other factors influencing the muscle activity were age, number of occluding tooth units and the extension of the lower implant bridge. It was concluded that patients with osseointegrated oral implant bridges have a masticatory muscle function equal to or approaching that in patients with natural teeth or with bridges supported on natural teeth with the same extension of the dentition.

Adult↗
PubMed1977

Bite force and oral function in patients with osseointegrated oral implants.

The function of the masticatory system was analyzed in 19 patients (13 women and 6 men), aged 39 to 68, randomly selected from a group of 165 patients who had been treated with osseointegrated oral implants within the last 7 years (average 3.5 years). The patients were well satisfied with the functional capacity of their implant reconstructions, especially compared with the poor function before treatment. According to the clinical examination, all but one patient had no or only mild symptoms of dysfunction of the masticatory system. Three bite-force levels were recorded. The mean value for gentle biting was 15.7 N, for biting as when chewing 50.1 N, AND FOR MAXIMAL BITING 144.4 N. The patients could thus well discriminate between the different bite-force levels, and the maximal values are much higher than those in persons with removable dentures.

Adult↗
PubMed1979

Silent period and jaw jerk reflex in patients with osseointegrated oral implant bridges.

The silent period in the masseter and in the anterior portion of the temporal muscle during tooth tapping, the rate of tooth tapping and the jaw jerk reflex evoked by a tap on the chin were compared in individuals with oral implant bridges and with natural teeth. Thirteen women with osseointegrated oral implant bridges in one or both jaws, aged 42-59 years, were compared with 10 women, aged 42-64 years, with natural teeth. There was no difference between women, aged 42-64 years, with natural teeth. There was no difference between women with implant bridges and those with natural teeth in tooth tapping rate or in the occurrence, latency or duration of the jaw jerk reflex. A silent period during tooth tapping was found in 12 of the 13 women with implant bridges. The latency of the silent period was the same as in the subjects with natural teeth but the duration tended to be somewhat longer. The jaw jerk and the silent period were the same in individuals with implants in both jaws as in the whole implant group. It is therefore concluded that periodontal or mucous membrane receptors cannot be solely responsible for the silent period.

Adult↗
PubMed2021

RNA-seq Analysis of Peri-Implant Tissue Shows Differences in Immune, Notch, Wnt, and Angiogenesis Pathways in Aged Versus Young Mice.

The number of total joint replacements (TJRs) in the United States is increasing annually. Cementless implants are intended to improve upon traditional cemented implants by allowing bone growth directly on the surface to improve implant longevity. One major complication of TJR is implant loosening, which is related to deficient osseointegration in cementless TJRs. Although poor osseointegration in aged patients is typically attributed to decreased basal bone mass, little is known about the molecular pathways that compromise the growth of bone onto porous titanium implants. To identify the pathways important for osseointegration that are compromised by aging, we developed an approach for transcriptomic profiling of peri-implant tissue in young and aged mice using our murine model of osseointegration. Based on previous findings of changes of bone quality associated with aging, we hypothesized that aged mice have impaired activation of bone anabolic pathways at the bone-implant interface. We found that pathways most significantly downregulated in aged mice relative to young mice are related to angiogenic, Notch, and Wnt signaling. Downregulation of these pathways is associated with markedly increased expression of inflammatory and immune genes at the bone-implant interface in aged mice. These results identify osseointegration pathways affected by aging and suggest that an increased inflammatory response in aged mice may compromise peri-implant bone healing. Targeting the Notch and Wnt pathways, promoting angiogenesis, or modulating the immune response at the peri-implant site may enhance osseointegration and improve the outcome of joint replacement in older patients. © 2021 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.

AGING↗
PubMed2026

The use of diode laser and scalpel blade in stage-two dental implant surgery: a comparative study.

OBJECTIVE: The use of lasers in dental implant procedures raises questions regarding the preservation of keratinized tissues and implant outcomes. This study aimed to compare the clinical effects (pain and impression time) and soft tissue healing (keratinization, peri-implant probing, bleeding, and healing) of diode lasers and scalpels used during stage-two dental implant surgery. METHOD AND MATERIALS: A prospective randomized clinical trial with a 1:1 allocation ratio was conducted. The study included 30 patients, each with a single, fully osseointegrated implant. Patients were categorized into two groups. The study group underwent stage-two implant surgery using a 970-nm diode laser. In the control group, implants were exposed using a conventional surgical blade. A comparison between the diode laser and conventional scalpel groups was made based on clinical outcomes (pain and impression time) and soft tissue healing (keratinization, peri-implant probing, bleeding, and healing). Data were analyzed using a paired t test. RESULTS: Pain intensity significantly decreased from immediate postoperative to 7 days in both scalpel (49.87 ± 6.78, t = 28.48, df = 14, P .001) and diode laser (7.67 ± 7.58, t = 3.91, df = 14, P = .002) groups. Immediately after surgery, pain scores were significantly higher in the scalpel group compared with the diode laser group (94.53 ± 4.45 vs 46.93 ± 5.85, t = 25.076, df = 26.151, P .001). Although pain decreased in both groups by day 7, the scalpel group continued to exhibit significantly greater pain (44.67 ± 5.96 vs 39.27 ± 3.73, t = 2.974, df = 23.513, P = .007). Impression time (P = .231) and gingival keratinized tissue (P = .736) did not differ significantly between the scalpel and diode laser approaches. At week 6, the scalpel group exhibited a significantly higher mean peri-implant bleeding index (2.60 ± 0.507) compared with the laser group (0.07 ± 0.258, P .001). However, after 12 weeks, no significant difference was observed (1.58 ± 0.19 vs 1.55 ± 0.21, P = .748). Laser surgery produced significantly better early wound healing at all intervals (P .001), while intraoperative bleeding was more common with the scalpel technique than with the diode laser (100.0% vs 66.7%, P = .042). CONCLUSION: Compared with the scalpel method, the diode laser method resulted in a significant reduction in pain intensity, improved wound healing, and less peri-implant bleeding during the stage-two dental implant surgery.

Humans↗