Facial paralysis--an aid for animal ophthalmoscopy.
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Dyflos (diisopropylphosphorofluoridate, DFP) retards the synthesis of lipid in the sciatic nerve of the chicken in vivo. A similar inhibition occurs in vitro, but only at relatively high concentrations (10(-3)M) of the drug. The major portion of the (14)C supplied as acetate, and incorporated into lipid, is found with the fatty acids. Attempts to separate the lipids involved by paper chromatography were unsuccessful.
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Experiments with tick-paralyzed dogs and woodchucks have shown impairment of stretch reflexes in addition to partial paralysis at the neuromuscular junction. Stretch reflexes disappear very early during paralysis, whereas nociceptive reflexes do not appear to be directly affected. The early incoordination and the ascending nature of the paralysis may be related to impairment of stretch reflex pathways.
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