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At least 19 recordsLinked to original sources
PubMed1962

Influence of guinea pig plasma factors on phagocytosis of Pasteurella pestis. I. Plasma from normal guinea pigs.

Stanziale, W. G. (Fort Detrick, Frederick, Md.) and J. D. White. Influence of guinea pig plasma factors on phagocytosis of Pasteurella pestis. I. Plasma from normal guinea pigs. J. Bacteriol. 83:175-181. 1962.-The existence of an enhancing effect of normal guinea pig plasma on the phagocytosis of Pasteurella pestis has been reaffirmed, using a test system consisting of neutrophils from normal nonimmune guinea pigs as the phagocytes. This enhancing influence was found to be attributable to the interplay of a thermolabile and a thermostable plasma component. The data suggest a consideration of complement as the thermolabile component, since the enhancing activity of plasma is destroyed by heating to 56 C and restored by addition of fresh plasma. The possibility that the thermolabile plasma component is opsonin was discounted. Surface alterations which did occur resulted in preserving the integrity of the envelope substance of the plague bacillus. Treatment of neutrophils with plasma prior to phagocytosis did not increase their phagocytic capacity. The thermostable enhancing component was not demonstrated to be present in any of three purified serum protein fractions tested. In fact, all of these fractions inhibited phagocytosis of P. pestis. An enhancing effect of purified fibrinogen could not be demonstrated.

Animals↗
PubMed1962

Influence of guinea pig plasma factors on phagocytosis of Pasteurella pestis. II. Plasma from plague-infected guinea pigs.

Stanziale, W. G. (Fort Detrick, Frederick, Md.) and J. D. White. Influence of guinea pig plasma factors on phagocytosis of Pasteurella pestis. II. Plasma from plague-infected guinea pigs. J. Bacteriol. 83:182-186. 1962.-The phagocytosis enhancing property of normal guinea pig plasma was altered during experimental plague infection. The most notable changes occurred in the plasma from afebrile, moribund animals and from those convalescing from acute infection. The plasma of the moribund guinea pigs, which was obtained 7 to 8 days after exposure to Pasteurella pestis, inhibited phagocytosis to a considerable degree. Plasma from convalescent guinea pigs enhanced phagocytosis to a higher degree than the plasma of normal animals. In contrast, plasma from recovered guinea pigs in which cultural or serological evidence of infection was not demonstrated enhanced phagocytosis to a degree equivalent to that of normal plasma. Plasma taken from guinea pigs during the febrile phase of plague infection enhanced phagocytosis to a lower degree than did normal plasma.

Animals↗