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Results for “PERIPHLEBITIS”

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At least 19 recordsLinked to original sources

PubMed1992

Retinal periphlebitis in patients with acquired immunodeficiency syndrome with cytomegalovirus retinitis mimics acute frosted retinal periphlebitis.

Acute frosted retinal periphlebitis is an inflammatory condition of unknown origin characterized by marked perivenular infiltration in otherwise healthy patients. We encountered seven patients with acquired immunodeficiency syndrome who exhibited visual loss associated with an unusual diffuse retinal periphlebitis very similar in appearance to acute frosted retinal periphlebitis. Each patient developed a thick inflammatory infiltrate surrounding the retinal venules, creating a frosted appearance. Two cases were bilateral. All patients had areas of more typical cytomegalovirus retinitis in their involved eye(s). Five of six patients treated with ganciclovir sodium showed improvement not only of the cytomegalovirus retinitis but also of the periphlebitis. Although we do not have histopathologic evidence that cytomegalovirus was the cause of these cases of periphlebitis, we believe that periphlebitis may be a previously unrecognized finding of cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome. So far, there is no evidence implicating cytomegalovirus as the cause of acute frosted retinal periphlebitis in healthy patients.

Acquired Immunodeficiency Syndrome↗

PubMed1984

Multiple sclerosis: periphlebitis retinalis et cerebro-spinalis. A correlation between periphlebitis retinalis and abnormal technetium brain scintigraphy.

Periphlebitis retinae (PR) in multiple sclerosis (MS) is seen as transitory infiltrations around veins in the otherwise normal retina. Cellular infiltrations have been found around veins in the central nervous system (CNS), where it has been suggested that they are the first event in plaque formation. Technetium brain scans are usually normal in MS patients, but transitory abnormal scans of the cerebrum have been found in MS patients during acute attack or exacerbation. In order to test the hypothesis that active PR is a sign of simultaneous disease activity in the CNS, 29 technetium brain scans were carried out on 14 MS patients with active PR and on 15 MS patients without any signs of PR. Significantly more of the patients with active PR, compared with MS patients with previous PR, displayed abnormal brain scans. This indicates that a disruption of the blood brain barrier (BBB) and active PR occur simultaneously in MS.

Adolescent↗

PubMed1990

[Retinal periphlebitis and multiple sclerosis. Incidence, cerebrospinal fluid and results of visual evoked potentials].

In a retrospective study 323 patients with multiple sclerosis were screened for the incidence of retinal periphlebitis. The results of lumbar puncture and the visual evoked potentials were related to the eye disease. Retinal periphlebitis was seen in 19 patients (5.9%). Of the patients with retinal periphlebitis, 79% developed the eye pathology within the first 10 years of multiple sclerosis. The cerebrospinal fluid and visual evoked potentials were no different than the results in a control group of multiple sclerosis patients without periphlebitis. Multiple sclerosis should always be considered as one of the potential underlying diseases in retinal periphlebitis since it is found in 30% before or at the same time as the first neurological symptoms of multiple sclerosis.

Adult↗

PubMed1998

Phakic patients with cystoid macular edema, retinal periphlebitis, and vitreous inflammation.

OBJECTIVE: To characterize a group of phakic patients with idiopathic intermediate uveitis as defined by vitritis, cystoid macular edema, and retinal periphlebitis. DESIGN: Cross-sectional study. PARTICIPANTS: Nineteen phakic patients (35 eyes) with vitreous inflammation, cystoid macular edema, and/or retinal periphlebitis of unknown cause. INTERVENTION: None. MAIN OUTCOME MEASURES: Best-corrected final visual acuities, standardized clinical examinations, photographic and fluorescein angiographic evaluations, and class I and II HLA analysis on all 19 patients. RESULTS: Fifteen of the 19 patients were women. The mean age was 38 years, the mean follow-up was 104 months, and the mean duration of symptoms was 154 months. All 35 affected eyes had significant vitritis; 21 eyes (60%) had cystoid macular edema, 21 eyes (60%) had retinal periphlebitis. The median initial visual acuity was 20/30. The median final visual acuity was 20/20 with 32 (91%) of 35 eyes having 20/40 or better visual acuity at the final visit. No patient developed "snow-banks" or evidence of systemic disease, including multiple sclerosis or sarcoidosis, during the follow-up period. There were no statistically significant HLA associations in these patients compared with controls from another study from Iowa, but the Iowa phakic patients with cystoid macular edema did differ from the Iowa patients with pars-planitis at loci HLA-B8, HLA-B51, and HLA-DR2. CONCLUSIONS: We describe a disease entity of idiopathic intermediate uveitis that affects primarily young to middle-aged women and usually causes bilateral vitritis, cystoid macular edema, and retinal periphlebitis. Most patients retained good vision over a prolonged follow-up period. Multiple sequential examinations and HLA associations suggest that these conditions are distinct from other syndromes of intermediate uveitis, particularly parsplanitis.

Adolescent↗

PubMed1993

Frosted retinal periphlebitis in the acquired immunodeficiency syndrome.

Six patients with the acquired immunodeficiency syndrome had frosted periphlebitis associated with large areas of cytomegalovirus retinitis. Following the administration of ganciclovir, periphlebitis resolved within 2-6 weeks concomitant with quieting of cytomegalovirus retinitis. Frosted retinal periphlebitis in the acquired immunodeficiency syndrome is associated with cytomegalovirus retinitis in North America. Medical treatment of cytomegalovirus retinitis leads to resolution of the periphlebitis without the need for systemic corticosteroids.

AIDS-Related Opportunistic Infections↗

PubMedDate not supplied

Retinal periphlebitis resembling frosted branch angiitis with nonperfused central retinal vein occlusion.

PURPOSE: To report the unusual association between severe retinal periphlebitis resembling frosted branch angiitis and nonperfused central retinal vein occlusion (CRVO). METHODS: Observational case reports. RESULTS: Patient 1 was a 28-year-old man who presented with extensive sheathing involving all retinal veins in one eye followed by nonperfused CRVO. Twenty-seven months after initial presentation, he developed perfused CRVO in the other eye followed by periphlebitis that progressed into nonperfused CRVO. Patient 2 was a 47-year-old man who presented with unilateral severe retinal periphlebitis associated with nonperfused CRVO. Despite systemic administration of corticosteroid therapy, rubeosis iridis developed in both patients and neovascular glaucoma developed in Patient 1 despite full panretinal photocoagulation. Extensive systemic workup and coagulation studies were unremarkable except for the presence of antiphospholipid antibodies in both patients and elevated plasma homocysteine level in Patient 2. CONCLUSIONS: Severe retinal periphlebitis complicated by nonperfused CRVO is associated with poor visual outcome despite appropriate medical and surgical treatment.

Adult↗

PubMed1993

[Retinal periphlebitis in multiple sclerosis. A prospective study].

Twenty-four patients with clinically defined multiple sclerosis were prospectively studied with the aim of establishing the frequency of retinal periphlebitis. In three cases (12.5%) retinal periphlebitis was observed. None of the patients with multiple sclerosis and retinal periphlebitis presented a severe form or progressive course of the disease; however, in one patient it caused complete unilateral amaurosis. Aggressive immunosuppressive treatment was effective in one case. Given the absence of myelin in the retina, the presence of retinal periphlebitis suggests the existence of a vascular mechanism in the pathogenesis of multiple sclerosis.

Adult↗

PubMed1992

Acute frosted retinal periphlebitis associated with cytomegalovirus retinitis.

The clinical picture of an acute frosted periphlebitis has been reported in a limited number of otherwise healthy patients, and in one case of human immunodeficiency virus (HIV) infection. The disease is usually bilateral and highly sensitive to steroids. The case of a 26-year-old, HIV-seropositive woman who developed unilateral diffuse perivenous sheathing in the course of recurrent cytomegalovirus retinitis is reported. The appearance of the retinovasculitis was identical to that described as an acute frosted periphlebitis, and the disease proved to be highly sensitive to a combined treatment of steroids and ganciclovir. The clinical findings in this case support the possibility that the appearance of an acute frosted periphlebitis can occur in response to several different stimuli, including cytomegalovirus.

AIDS-Related Opportunistic Infections↗

PubMed1983

Retinal periphlebitis as an early sign of bacterial endophthalmitis.

Retinal periphlebitis appeared as an early sign of bacterial endophthalmitis in three patients, a 36-year-old man with bilateral Terson's syndrome who underwent vitrectomy for dense vitreous hemorrhage, a 78-year-old woman who had had intracapsular cataract extraction and penetrating keratoplasty after repair of a wound leak and pars plana anterior membranectomy, and an 18-year-old man who suffered an accidental penetrating ocular injury. Staphylococcus organisms were recovered from vitreous samples in all three cases. Although recovery of useful vision is rare after postvitrectomy endophthalmitis, the first patient attained a final visual acuity of 20/50. The visual acuities of the second and third patients returned to 20/25 and 20/20 respectively. In an experimental primate (cynomolgus monkey) model of bacterial endophthalmitis, retinal periphlebitis developed early and closely resembled the clinical findings in humans. Histopathologic studies confirmed the presence of inflammatory cells that infiltrated the retinal venules.

Adolescent↗

PubMed1987

Chronic periphlebitis retinae in multiple sclerosis. A histopathological study.

Retinal periphlebitis in multiple sclerosis is of particular interest in relation to our understanding of the pathogenesis of the demyelinating central nervous system plaques. Previous studies have largely been clinical, and there is little detailed histopathological information relating to this condition. We present the first detailed report in the neurological literature on the histological findings in chronic periphlebitis retinae associated with multiple sclerosis. The most significant abnormalities of the affected retinal veins were the presence of thick laminated collagen in the wall, associated with a scanty infiltration of plasma cells.

Adolescent↗

PubMed1992

Severe periphlebitis, peripheral retinal ischemia, and preretinal neovascularization in patients with multiple sclerosis.

Two patients with definite multiple sclerosis and marked retinal periphlebitis developed occlusive peripheral retinal vasculitis, which resulted in peripheral retinal ischemia and peripheral retinal neovascularization. Results of investigation for other causes of peripheral proliferative retinopathies were negative in both patients although one patient had a positive anticardiolipin antibody. Both patients have been followed up for over seven years and have maintained good visual acuity with mild regression of the preretinal neovascularization without laser intervention. An analysis of these two cases and six other reported cases indicates that severe periphlebitis can evolve into occlusive peripheral vasculitis, which results in peripheral retinal neovascularization in patients with multiple sclerosis.

Adult↗

PubMed1984

Retinal periphlebitis and retinitis in multiple sclerosis. I. Pathologic characteristics.

Eyes from 47 autopsy cases of multiple sclerosis were studied pathologically. Lymphocytic or granulomatous retinal periphlebitis was found in four cases (seven eyes); focal lymphocytic or granulomatous retinitis was present in three cases (five eyes). These findings were correlated with optic nerve changes (periphlebitis, neuritis, leptomeningitis, and atrophy), retinal venous sclerosis, uveitis, central nervous system involvement, clinical activity of disease at death, and with ultrastructural and immunopathological retinal findings.

Humans↗

PubMed1999

[Periphlebitis retinae, uveitis and cystoid maculopathy in a patient with multiple sclerosis].

PATIENT: A 44-year-old woman has a history of multiple sclerosis since 20 years. Besides recurrent numbness she had many instances of optic nerve neuritis which has led to a pronounced optic atrophy on her left eye. Additionally, she has developed recurrent iridocyclitis on her right eye. This was the reason why she was referred to our outpatient department for evaluation. Ophthalmic examination revealed an iridocyclitis associated with a multifocal retinal periphlebitis and severe cystoid macular edema in her right eye. CONCLUSION: Patients with multiple sclerosis develop in approximately 30% of cases retinal periphlebitis which may rarely be associated with anterior uveitis or cystoid macular edema as observed in our patient.

Adult↗

PubMed1989

[Periphlebitis retinae ("Rucker")--a symptom of disseminated encephalomyelitis].

Within a group of neuro-ophthalmic patients (147 patients with either florid or cured optic neuritis (ON), five (3.4%) were found to be suffering from retinal periphlebitis "Rucker". Of these five patients, three were also suffering from Encephalomyelitis disseminata (E.d.). One patient had ON without E.d.; in another there were sufficient grounds for a tentative diagnosis of ON during the follow-up period. The relatively low percentage of patients with retinal periphlebitis associated with a basic demyelinating condition can be attributed primarily to the fact that the group of patients examined consisted of neuro-ophthalmic patients in most of whom the basic disease manifested itself for the first time. The multi-focal processes involved in demyelinating diseases become apparent through inflammatory focuses with varying degrees of activity, often in the same eye.

Adult↗

PubMed1985

Periphlebitis retinae in multiple sclerosis. A histopathological study of two cases.

The reported findings of periphlebitis retinae (PR) at autopsy, in which brain autopsy was also performed, in 2 patients with multiple sclerosis (MS) are, so far as the authors are aware, the first histological account of this manifestation of the disease. The similarity between the cellular accumulations around the veins of the central nervous system seen in multiple sclerosis and the periphlebitic cellular accumulations here described suggests that periphlebitis is an initial event in plaque formation.

Adult↗

PubMed1990

Retinal periphlebitis in ulcerative colitis.

A man presented with unilateral visual blurring associated with bilateral retinal periphlebitis which was felt to be a complication of his biopsy-proven active ulcerative colitis. Retinal periphlebitis has been associated rarely with some forms of colitis but we can find no report of its occurrence in association with ulcerative colitis although other ocular inflammatory disorders are well recognized.

Adult↗

PubMed2000

[Retinal periphlebitis as early sign of endophthalmitis].

CASE REPORT: 75 year-old woman was operated for cataract by means of phacoemulsification without complications. Four days after she came for suddenly blurred vision and floaters; on ocular examination there was a periphlebitis in the fundus. On the following day, an endophthalmitis with typical signs and symptoms was evident. DISCUSSION: Endophthalmitis is one of the most serious complications of the cataract surgery; therefore, an early diagnosis and treatment is necessary to preserve an adequate visual function. One of the earliest sings of bacterial endophthalmitis, seldom found, is a retinal periphlebitis, which the ophthalmologist must know and make a prompt decision.

Aged↗

PubMed2001

[Retrospective analysis of argon laser for treating retinal periphlebitis].

OBJECTIVES: This article was to investigate the curative effect of argon laser photocoagulation for retinal periphlebitis treatment, and then to discuss the stage of the treatment. METHODS: According to the condition of vitreous hemorrhage and the range of retinal neovascularization, 31 cases (34 eyes) were divided into the light group and the heavy group, and the therapeutic effective rate, the condition of visual acuity and vitreous hemorrhage were compared. RESULTS: The therapeutic effective rate was 64.71%, there was significant difference in effective rate and prognosis of visual acuity between two groups (P < 0.01). After laser treatment, the morbidity of vitreous hemorrhage in heavy group decreased from 100% to 18.70%. CONCLUSION: Argon laser photocoagulation is an effective method for treating retinal periphlebitis and early treatment is recommended.

Adolescent↗