The biological behaviour of canine oral and pharyngeal neoplasms.
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Cancer of the upper digestive tract is very common among males in Switzerland in comparison with 19 other industrialized countries. The sex ratio is closely correlated with the mortality rates in men in these countries. Cancers of these sites are relatively more frequent among young adults than for all the other sites. After a brief review of the main risk factors the discussion focuses on tobacco and alcoholic beverages consumption. The distribution of these two risk factors and their relationship to age in a sample of 226 patients in Lausanne is discussed. If compared, the geographical variations in Switzerland of both the occurrence of the disease and the amount of alcoholic beverages consumed suggests an association. Finally, it seems likely that carcinogenic substances exist in some of the Swiss beverages. A research hypothesis related to the difference between the mutagenic properties of the beverages used by cancer patients and by controls is proposed for further study.
OBJECTIVE: To study the repair methods of the defect after resecting pharyngeal neoplasm and laryngeal neoplasm. METHODS: Four kinds of tongue flap, such as 1/3 tongue flap, 1/2 tongue base flap, tongue base flap and transverse tongue flap were devised and applied in 15 patients with pharyngeal neoplasm and laryngeal neoplasm. RESULTS: These tongue flaps were alive in all patients. The wound of 13 patients healed in I stage. Two patients dehiscenced because of infection and healed after treatment. All the patients deglutited well. One-year, 3-year, disease-free survive rate were 92.9% (13/14), 72.7% (8/11) respectively. CONCLUSION: Tongue flaps are obtained easily, with enough blood flow, adapted to pharyngeal environment, easily alive and low complication in repairing the pharyngeal defect. We think that these tongue flaps should be applied in clinic.
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The treatment of carcinomas of oropharynx and oral cavity has changed rapidly over the last 15 years due to the progress of surgical technics and of oncological knowledge. As far as natural history and therapy are concerned, there are two opposing types of cancer: 1. Carcinomas developing from a mucous membrane covering a lymphoid tissue (cancers of the tonsil, some cancers of the palate and the base of tongue). Treatment is usually by radiotherapy, and surgery is mainly resorted to if radiotherapy fails. Therapeutic trials of chemotherapy are in progress. 2. Carcinomas developing from a mucous membrane covering muscles (cancers of the tongue, floor of the mouth and interval cheek) or bone of the mandible (carcinomas of the gingiva, floor of the mouth and gingiva, and retro-alveolar area). The therapy is described. The principles of treatment of the regional lymph nodes are also described.
The purpose of the study was a comparison of clinical and pathological assessment of cervical lymph nodes metastases in advanced carcinoma of larynx and the hypopharynx. The outspread, size and number of the nodes metastases to the particular regions of the neck was taken into analysis. The differences and occurrence in clinical and pathological assessment was pointed out.
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In incurable cancer of the mouth and oropharynx, reasonable palliative therapy should render the patient's remaining life-span worth living. The following problems impair tumor patient's well-being: 1. pain, 2. ingestive and respiratory difficulties, 3. aspect, 4. odor, 5. psychic trauma resulting from 3 and 4. Pain, either caused by the tumor itself or as a reaction to irradiation or inflammatory response, is of primary importance. Impairment of ingestion, respiration, and speech diminishes the quality of life. Disfigurement of the face or a penetrating odor may sometimes cause additional psychic stress. Besides palliative radio- and chemotherapy, in certain cases palliation can be obtained by surgery, which may reduce the size of a cosmetically disturbing tumor mass or create a clean wound surface easier to care for than a necrotic surface. Furthermore, painful neuralgic nerve branches may be severed. Severe lymphedema of the face and neck may be improved by lumbo-peritoneal shunt operation. Most recently, cryosurgery has won an established place in the management of these problems, although certain restrictions must be observed. Superficial recurrences can be treated without further mutilation of the patient. Painful areas of the tumor can be eradicated. Recurrences in the hypopharynx, which are accessible with difficulty only, can be treated with a cryosonde with little harm to an already impaired patient. Multiple tumor lesions can be iced at the same time. Among the reasonable palliative methods of treatment, synchronized irradiation and chemotherapy as well as implantation of solid radioactive substances must be mentioned.
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The results of the treatment of 340 patients with malignant tumors in the laryngopharynx show the advantages of combined and surgical methods over radiation therapy: five-year survival after application of the above methods made up 43% and 12%, respectively. A new method of autovenous plastics of carotid artery is proposed to treat advanced metastatic tumors. Different variants of restoring pharyngeal integrity after the destructive operations are evaluated.
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