[Fermentative oxidation of rho-hydroxyphenylpyruvic acid to homogentisic acid].
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The oral administration of phenylpyruvic acid to human subjects results in increased urinary excretion of o-hydroxyphenylacetic acid. This demonstrates that phenylpyruvic acid may act as a precursor for o-hydroxy derivatives of phenylalanine and suggests that the formation of o-tyrosine is not necessary to account for the excretion of o-hydroxyphenylacetic acid in phenylketonuria.
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